Takeda Pharmaceutical (US)
Sr. Scientist, Computational Chemistry
Takeda Pharmaceutical (US), Boston, Massachusetts, us, 02298
Job Description
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Objective / Purpose:
As a Computational Chemistry Scientist, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientists, Structural Biologists, Pharmacologists and Biologists to provide computational expertise to advance drug discovery projects.
Contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.
Implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.
Accountabilities:
Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects.
Build and develop a strong team of Computational Chemists to high productivity levels.
Demonstrate leadership and enterprise thinking in managing multi-disciplinary team.
Dimensions and Aspects:
Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis.
Significant industry experience contributing as Computational Chemist on drug discovery projects.
Strong impact in progressing discovery projects from hits to clinical leads.
Extensive knowledge & experience in using a variety of tools for hit ID.
Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
Proficiency with state-of-the-art computational chemistry software.
Network with renowned researchers in computational chemistry/AI.
Education, Behavioral Competencies and Skills:
PhD degree in a relevant scientific discipline.
2+ years of industry (pharma/biotech) drug discovery experience required.
Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location: Boston, MA
U.S. Base Salary Range: $137,000.00 - $215,270.00
Salary details may vary based on qualifications, experience, skills, education, and location. U.S. based employees may be eligible for short-term and/or long-term incentive compensation, participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits. U.S. based employees are also eligible to receive up to 80 hours of sick time per calendar year, and new hires accrue up to 120 hours of paid vacation.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations Boston, MA
Worker Type Employee
Worker Sub-Type Regular
Time Type Full time
Job Exempt Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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Objective / Purpose:
As a Computational Chemistry Scientist, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientists, Structural Biologists, Pharmacologists and Biologists to provide computational expertise to advance drug discovery projects.
Contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.
Implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.
Accountabilities:
Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects.
Build and develop a strong team of Computational Chemists to high productivity levels.
Demonstrate leadership and enterprise thinking in managing multi-disciplinary team.
Dimensions and Aspects:
Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis.
Significant industry experience contributing as Computational Chemist on drug discovery projects.
Strong impact in progressing discovery projects from hits to clinical leads.
Extensive knowledge & experience in using a variety of tools for hit ID.
Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
Proficiency with state-of-the-art computational chemistry software.
Network with renowned researchers in computational chemistry/AI.
Education, Behavioral Competencies and Skills:
PhD degree in a relevant scientific discipline.
2+ years of industry (pharma/biotech) drug discovery experience required.
Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location: Boston, MA
U.S. Base Salary Range: $137,000.00 - $215,270.00
Salary details may vary based on qualifications, experience, skills, education, and location. U.S. based employees may be eligible for short-term and/or long-term incentive compensation, participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits. U.S. based employees are also eligible to receive up to 80 hours of sick time per calendar year, and new hires accrue up to 120 hours of paid vacation.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations Boston, MA
Worker Type Employee
Worker Sub-Type Regular
Time Type Full time
Job Exempt Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
#J-18808-Ljbffr