Integrated Resources, Inc ( IRI )
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Integrated Resources, Inc ( IRI ) provided pay range This range is provided by Integrated Resources, Inc ( IRI ). Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range $50.00/hr - $52.00/hr
Direct message the job poster from Integrated Resources, Inc ( IRI )
Lead Recruiter at Integrated Resources Inc. (IRI) Notes:
Must be able to commute to work every day
PhD is required
Must have experience with Analytical Chemistry
Must have experience with Oligonucleotides
Must have siRNA experience
Previous gene therapy experience
Must have 1-3 years of experience
Experience with Chromatography (LC-MS)
Experience with these instruments: Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS
Description:
Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Seniority level
Mid-Senior level
Employment type
Contract
Job function
Research
Pharmaceutical Manufacturing and Biotechnology Research
#J-18808-Ljbffr
Integrated Resources, Inc ( IRI ) provided pay range This range is provided by Integrated Resources, Inc ( IRI ). Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range $50.00/hr - $52.00/hr
Direct message the job poster from Integrated Resources, Inc ( IRI )
Lead Recruiter at Integrated Resources Inc. (IRI) Notes:
Must be able to commute to work every day
PhD is required
Must have experience with Analytical Chemistry
Must have experience with Oligonucleotides
Must have siRNA experience
Previous gene therapy experience
Must have 1-3 years of experience
Experience with Chromatography (LC-MS)
Experience with these instruments: Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS
Description:
Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Seniority level
Mid-Senior level
Employment type
Contract
Job function
Research
Pharmaceutical Manufacturing and Biotechnology Research
#J-18808-Ljbffr