MSD Ireland
Associate Principal Scientist (Computational), Process & Product Modeling - Larg
MSD Ireland, West Point, Pennsylvania, us, 19486
Associate Principal Scientist (Computational), Process & Product Modeling – Large Molecules
Join our Process & Product Modeling Team as an Associate Principal Scientist, leading advanced computational modeling that accelerates the development and commercialization of biologics, vaccines, sterile liquids, and other large‑molecule therapies. Responsibilities
Collaborate with multidisciplinary scientists and engineers to create end‑to‑end predictive models supporting drug substance and drug product manufacturing. Develop mechanistic and data‑driven models for chromatography, filtration, process flowsheets, process economics, and digital twins to address manufacturing challenges in biologics and vaccines. Drive innovation by championing computational tools that reduce costs, minimize experimental batches, shorten timelines, and improve product quality and process robustness. Lead deployment of computational solutions using commercial software, open‑source tools, and proprietary models. Manage multiple projects with minimal supervision, presenting results to internal teams, conferences, and publications. Collaborate with external partners such as universities and CMOs/CDMOs to advance modeling capabilities. Required Qualifications
PhD with 4+ years or MS with 8+ years of relevant experience in Chemical, Biochemical, Mechanical, Biological, Pharmaceutical Engineering, or related fields. Strong research background in computational modeling applied to large‑molecule biologics manufacturing. Expertise in one or more: mechanistic chromatography modeling, end‑to‑end flowsheet/digital twin modeling, plant/process economics, bioreactor kinetics, population balance models, engineering transport models, or data‑driven modeling. Experience with modeling software (GoSilico, CADET, SuperPro, ASPEN Plus, gPROMS, BioSolve, Dynochem) and programming languages (Python, Matlab, C/C++, R). Excellent organizational, interpersonal, and communication skills; proven ability to work effectively in cross‑functional teams. Industrial or relevant research experience with biologics, vaccines, or sterile liquid manufacturing processes. Preferred Qualifications
Demonstrated success in applying modeling outcomes in commercial and cGMP environments. Familiarity with regulatory filings (BLAs, NDAs) and CMC processes. Experience with high‑performance computing and machine learning or AI techniques. Strong publication, presentation, or patent record. Location
West Point, PA | Rahway, NJ | Greater Dublin Area, Ireland Compensation
$139,600.00 – $219,700.00 per year, eligible for annual bonus and long‑term incentive. Comprehensive benefits package available. Application Deadline
10/17/2025 Equal Employment Opportunity
We are an equal opportunity employer. All qualified applicants will receive consideration.
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Join our Process & Product Modeling Team as an Associate Principal Scientist, leading advanced computational modeling that accelerates the development and commercialization of biologics, vaccines, sterile liquids, and other large‑molecule therapies. Responsibilities
Collaborate with multidisciplinary scientists and engineers to create end‑to‑end predictive models supporting drug substance and drug product manufacturing. Develop mechanistic and data‑driven models for chromatography, filtration, process flowsheets, process economics, and digital twins to address manufacturing challenges in biologics and vaccines. Drive innovation by championing computational tools that reduce costs, minimize experimental batches, shorten timelines, and improve product quality and process robustness. Lead deployment of computational solutions using commercial software, open‑source tools, and proprietary models. Manage multiple projects with minimal supervision, presenting results to internal teams, conferences, and publications. Collaborate with external partners such as universities and CMOs/CDMOs to advance modeling capabilities. Required Qualifications
PhD with 4+ years or MS with 8+ years of relevant experience in Chemical, Biochemical, Mechanical, Biological, Pharmaceutical Engineering, or related fields. Strong research background in computational modeling applied to large‑molecule biologics manufacturing. Expertise in one or more: mechanistic chromatography modeling, end‑to‑end flowsheet/digital twin modeling, plant/process economics, bioreactor kinetics, population balance models, engineering transport models, or data‑driven modeling. Experience with modeling software (GoSilico, CADET, SuperPro, ASPEN Plus, gPROMS, BioSolve, Dynochem) and programming languages (Python, Matlab, C/C++, R). Excellent organizational, interpersonal, and communication skills; proven ability to work effectively in cross‑functional teams. Industrial or relevant research experience with biologics, vaccines, or sterile liquid manufacturing processes. Preferred Qualifications
Demonstrated success in applying modeling outcomes in commercial and cGMP environments. Familiarity with regulatory filings (BLAs, NDAs) and CMC processes. Experience with high‑performance computing and machine learning or AI techniques. Strong publication, presentation, or patent record. Location
West Point, PA | Rahway, NJ | Greater Dublin Area, Ireland Compensation
$139,600.00 – $219,700.00 per year, eligible for annual bonus and long‑term incentive. Comprehensive benefits package available. Application Deadline
10/17/2025 Equal Employment Opportunity
We are an equal opportunity employer. All qualified applicants will receive consideration.
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