Alaka`ina Foundation Family of Companies
Cell & Systems Biology Staff Scientist
Alaka`ina Foundation Family of Companies, Frederick, Maryland, United States, 21701
The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a
Cell & Systems Biology Staff Scientist
to support our government customer located in Fort Detrick, Frederick, MD. DESCRIPTION OF RESPONSIBILITIES: Generate various reporter-based functional assays and evaluate pathogens as well as small molecule library using the reporter assay. Use multi-array technologies such as opera high-content imaging, flow cytometry, real-time PCR, cytokine assays using MESO scale discovery’s (MSD) and biochemical assays (immunoprecipitation/western blot) to further characterize the mechanism of action of the therapeutics. Support analysis of high throughput data using Spotfire and Genedata. Participate in characterization of suitable lead compound for broad spectrum use against multiple bio-threat agents. Conduct research directed towards developing an integrated multi-omics (genomics, transcriptomics, and proteomics) approach to design and test various pathogens in vitro and/or in vivo, carry out analysis of large datasets using data mining tools such as Ingenuity, Nextbio, Metascape, Cytoscape, and use the dataset to extract key features, regulatory networks, and identify host correlates related to infectious disease. This information shall guide the therapeutic discovery project. Perform various assays including functional genomic screens and proteomic studies to identify novel host factors that modulate the innate immune signaling pathways to bacterial biothreat pathogens such as B. anthracis, Burkholderia mallei, and B. pseudomallei, and viral pathogens such as filoviruses and alphaviruses. Maintain an orderly laboratory environment in compliance with regulations. Coordinate ordering of supplies to support research efforts with division staff. Assist in training new personnel including students and other technicians and mentoring junior scientists. Communicate experimental data and laboratory or other work-related issues to the appropriate POC. Communicate with vendors for technical support and troubleshooting laboratory equipment within their assigned space. Assist in the preparation of technical reports and standard operating procedures. Write manuscripts and, if required, present research findings at scientific conferences. Present results in written and oral format publicly and internally. Prepare monthly TDC cell and systems biology progress report. Present research findings at monthly lab meetings and attend scientific discussion weekly meetings. In collaboration with USAMRIID leadership, author or coauthor research proposals, solicitations, and other vehicles to solicit financial support to meet USAMRIID mission/portfolio objectives. Assist to answer service calls from government sponsors (e.g., DTRA). Assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. Employee may be expected to present research findings at scientific conferences. Present results in written and oral format publicly and internally as requested. REQUIRED DEGREE/EDUCATION/CERTIFICATION: A Ph.D. is required in the field of biological or life sciences. REQUIRED SKILLS AND EXPERIENCE: The position requires experience (> 3yrs.) in the field of Innate Immunology with a special emphasis on using systems biology to study host-pathogen interactors and carrying out analysis of large OMIC datasets. Directly perform experimental research and provide support in a range of biochemical, cell biological, immunological, systems biology, and standardization of assays towards therapeutics development. REQUIRED CITIZENSHIP AND CLEARANCE: U.S. Citizen Must pass NACI background check. Must be willing to work in a BSL 3/4 laboratory. Must be eligible to enroll in the BPRP and CS-PRP programs. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees enjoy a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 11 paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. We are proud to state that we do not illegally discriminate in employment decisions on the basis of any protected categories. If you
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Cell & Systems Biology Staff Scientist
to support our government customer located in Fort Detrick, Frederick, MD. DESCRIPTION OF RESPONSIBILITIES: Generate various reporter-based functional assays and evaluate pathogens as well as small molecule library using the reporter assay. Use multi-array technologies such as opera high-content imaging, flow cytometry, real-time PCR, cytokine assays using MESO scale discovery’s (MSD) and biochemical assays (immunoprecipitation/western blot) to further characterize the mechanism of action of the therapeutics. Support analysis of high throughput data using Spotfire and Genedata. Participate in characterization of suitable lead compound for broad spectrum use against multiple bio-threat agents. Conduct research directed towards developing an integrated multi-omics (genomics, transcriptomics, and proteomics) approach to design and test various pathogens in vitro and/or in vivo, carry out analysis of large datasets using data mining tools such as Ingenuity, Nextbio, Metascape, Cytoscape, and use the dataset to extract key features, regulatory networks, and identify host correlates related to infectious disease. This information shall guide the therapeutic discovery project. Perform various assays including functional genomic screens and proteomic studies to identify novel host factors that modulate the innate immune signaling pathways to bacterial biothreat pathogens such as B. anthracis, Burkholderia mallei, and B. pseudomallei, and viral pathogens such as filoviruses and alphaviruses. Maintain an orderly laboratory environment in compliance with regulations. Coordinate ordering of supplies to support research efforts with division staff. Assist in training new personnel including students and other technicians and mentoring junior scientists. Communicate experimental data and laboratory or other work-related issues to the appropriate POC. Communicate with vendors for technical support and troubleshooting laboratory equipment within their assigned space. Assist in the preparation of technical reports and standard operating procedures. Write manuscripts and, if required, present research findings at scientific conferences. Present results in written and oral format publicly and internally. Prepare monthly TDC cell and systems biology progress report. Present research findings at monthly lab meetings and attend scientific discussion weekly meetings. In collaboration with USAMRIID leadership, author or coauthor research proposals, solicitations, and other vehicles to solicit financial support to meet USAMRIID mission/portfolio objectives. Assist to answer service calls from government sponsors (e.g., DTRA). Assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. Employee may be expected to present research findings at scientific conferences. Present results in written and oral format publicly and internally as requested. REQUIRED DEGREE/EDUCATION/CERTIFICATION: A Ph.D. is required in the field of biological or life sciences. REQUIRED SKILLS AND EXPERIENCE: The position requires experience (> 3yrs.) in the field of Innate Immunology with a special emphasis on using systems biology to study host-pathogen interactors and carrying out analysis of large OMIC datasets. Directly perform experimental research and provide support in a range of biochemical, cell biological, immunological, systems biology, and standardization of assays towards therapeutics development. REQUIRED CITIZENSHIP AND CLEARANCE: U.S. Citizen Must pass NACI background check. Must be willing to work in a BSL 3/4 laboratory. Must be eligible to enroll in the BPRP and CS-PRP programs. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees enjoy a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 11 paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. We are proud to state that we do not illegally discriminate in employment decisions on the basis of any protected categories. If you
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