Post-Doc Research Associate - Brouwer Lab

A postdoctoral research position is available immediately to investigate the utility of in vitro models (e.g., hepatic organoid 3D cell models, sandwich-cultured hepatocytes, HuH-7 cells, membrane vesicle systems) to: Predict the hepatic disposition of drugs and metabolites in vivo. Predict the impact of disease-mediated alterations in transport function on hepatocellular accumulation and routes of excretion (canalicular vs. basolateral) of anionic drugs/metabolites. Examine hepatic transporter trafficking and regulatory mechanisms. This is an NIH-funded research program to study the hepatic disposition of xenobiotics utilizing in vitro model systems, regulation/trafficking of transport proteins, and cellular/molecular mechanisms responsible for hepatic structure and function. Research includes but is not limited to: In vitro cell culture experiments. Transport assays. Western Blotting. Cloning and mutagenesis. Immunohistochemical imaging and live cell imaging. LC-MS/MS. Maintaining the laboratory’s animal care and use and radiation safety records in accordance with institutional, state, and federal guidelines.

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