Vertex Pharmaceuticals
Executive Medical Director, Translational Medicine
Vertex Pharmaceuticals, Boston, Massachusetts, us, 02298
Job Description
The Executive Medical Director, Translational Medicine, Early Development will be a strategically minded, hands‑on early clinical development expert with the responsibility for overseeing the transition of projects from research into clinical development, and for developing strategy for early clinical development of novel therapies including application of biomarkers in Phase 1b/2a studies. Success depends on the integrity, knowledge, imagination, creativity, skill, diversity and teamwork focus of the candidate. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. The individual will collaborate with talented and dedicated colleagues across R&D, Clinical & Quantitative Pharmacology, and other key stakeholder functions. This position will be a critical element in Vertex's approach to creating an effective bridge between discovery research and clinical development.
Key Duties and Responsibilities
Leading a group of physician‑scientists involved in clinical research
Work closely with other functional experts across the organization
Provide medical leadership and translational medicine expertise on cross‑functional Project Teams
Co‑chair of Protocol Review Committee (ePPRC) and Dose Escalation Meetings (DEM) meetings for Phase 1 SAD/MAD studies
Develop early clinical development plans that are innovative, safe, efficient and create a foundation for decision making
Provide clinical and translational leadership to drive the design and interpretation of Phase 1‑2a studies, in close collaboration with experts in Clinical Biomarkers, Clinical Pharmacology, Modeling & Simulation, and Clinical Operations
Work with teams to ensure effective execution of Phase 1‑2a studies
Collaborate with Global Patient Safety to perform safety evaluations in early development programs
Support exploratory biomarker efforts in collaboration with Clinical Biomarkers and Research groups to aid in clinical and project decision making
Engage with external academic and industry partners in planning and executing strategy and clinical studies
Engage with external scientific and medical experts to bring insight to development programs
Work with colleagues across the research and clinical organizations to foster an end‑to‑end view of drug development, with a focus on improving patient care
Serve as a people manager and mentor within the organization to young new‑to‑industry physicians
Have financial accountabilities and human resource responsibilities for assigned staff
Knowledge and Skills
Global clinical research experience, and experience interacting with regulatory authorities is highly desired
Ability to work collaboratively in a fast‑paced, matrix environment
Ability to work independently to resolve challenges
Enterprise‑wide thinking and ability to work in ambiguity
Excellent oral and written communication skills
Board certification/eligibility in a specialty is highly desired
Education and Experience
MD, DO or equivalent ex‑US medical degree required + PhD (highly desired)
15+ years of translational medicine/translational research experience, including time managing clinical trials and clinical development programs
Strong record of basic and/or translational research productivity
Experience with design, execution, and analysis of Phase 1‑2a, first‑in‑human and POM/POC clinical studies
Experience across multiple therapeutic areas and modalities
Effective at building alliances across functions
Excellent interpersonal communication skills, able to drive collaborations across a matrixed organization
People‑management experience required
#LI-KM4
Pay Range $312,000 - $468,000
Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation Hybrid‑Eligible Or On‑Site Eligible
Flex Eligibility Status In this Hybrid‑Eligible role, you can choose to be designated as:
1.
Hybrid : work remotely up to two days per week; or 2.
On‑Site : work five days per week on‑site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
Company Information Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
#J-18808-Ljbffr
Key Duties and Responsibilities
Leading a group of physician‑scientists involved in clinical research
Work closely with other functional experts across the organization
Provide medical leadership and translational medicine expertise on cross‑functional Project Teams
Co‑chair of Protocol Review Committee (ePPRC) and Dose Escalation Meetings (DEM) meetings for Phase 1 SAD/MAD studies
Develop early clinical development plans that are innovative, safe, efficient and create a foundation for decision making
Provide clinical and translational leadership to drive the design and interpretation of Phase 1‑2a studies, in close collaboration with experts in Clinical Biomarkers, Clinical Pharmacology, Modeling & Simulation, and Clinical Operations
Work with teams to ensure effective execution of Phase 1‑2a studies
Collaborate with Global Patient Safety to perform safety evaluations in early development programs
Support exploratory biomarker efforts in collaboration with Clinical Biomarkers and Research groups to aid in clinical and project decision making
Engage with external academic and industry partners in planning and executing strategy and clinical studies
Engage with external scientific and medical experts to bring insight to development programs
Work with colleagues across the research and clinical organizations to foster an end‑to‑end view of drug development, with a focus on improving patient care
Serve as a people manager and mentor within the organization to young new‑to‑industry physicians
Have financial accountabilities and human resource responsibilities for assigned staff
Knowledge and Skills
Global clinical research experience, and experience interacting with regulatory authorities is highly desired
Ability to work collaboratively in a fast‑paced, matrix environment
Ability to work independently to resolve challenges
Enterprise‑wide thinking and ability to work in ambiguity
Excellent oral and written communication skills
Board certification/eligibility in a specialty is highly desired
Education and Experience
MD, DO or equivalent ex‑US medical degree required + PhD (highly desired)
15+ years of translational medicine/translational research experience, including time managing clinical trials and clinical development programs
Strong record of basic and/or translational research productivity
Experience with design, execution, and analysis of Phase 1‑2a, first‑in‑human and POM/POC clinical studies
Experience across multiple therapeutic areas and modalities
Effective at building alliances across functions
Excellent interpersonal communication skills, able to drive collaborations across a matrixed organization
People‑management experience required
#LI-KM4
Pay Range $312,000 - $468,000
Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation Hybrid‑Eligible Or On‑Site Eligible
Flex Eligibility Status In this Hybrid‑Eligible role, you can choose to be designated as:
1.
Hybrid : work remotely up to two days per week; or 2.
On‑Site : work five days per week on‑site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
Company Information Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
#J-18808-Ljbffr