Eli Lilly and Company
Process Development Engineer – Early Phase Peptide/Oligonucleotide
Eli Lilly and Company, Indianapolis, Indiana, us, 46262
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people who are determined to make life better for others. Job Description: Synthetic Molecule Design and Development (SMDD) develops synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization. Our scientists and engineers provide technical and business solutions across the portfolio to accelerate testing of clinical hypotheses and drug development. SMDD values diverse talent and cultures to bring the next generation of medicines to patients. SMDD has an opportunity for an innovative chemical engineer to join the engineering group within its early phase TIDES (peptide and oligonucleotide) team. The engineer will join a cross-functional team developing synthetic peptide processes and facilitating technology transfer and scale-up to pilot plant, delivering product and process understanding across TIDES platforms. The early phase TIDES team develops synthesis processes to rapidly deliver pilot toxicology study materials for next generation therapeutic peptides. The engineer will gain experience with synthetic molecule unit operation design and data-rich experimentation to address synthesis challenges and advance peptide process development. Position Responsibilities
Generate process design and unit operation knowledge for small molecules, peptides, oligonucleotides, and other emerging therapeutic modalities. Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge. Design and execute laboratory experiments related to solid-phase and liquid-phase peptide and oligonucleotide synthesis, and downstream purification and isolation. Develop drug substance and manufacturing technologies. Provide creative solutions to improve existing processes and create novel ones. Transfer process technical information to internal pilot plant and provide technical oversight for pilot-scale GMP manufacturing activities. Author and maintain documentation such as laboratory notebooks and technical reports. Apply engineering and business principles to design and characterize synthetic processes. Use numerical modeling to analyze reaction kinetics, mechanisms, and separations. Design efficient process and equipment flow strategies, selecting appropriate equipment for each process. Stay informed about new technology and best practices; propose, justify, evaluate, and implement new equipment, processing techniques, and technologies. Utilize technology to improve safety, quality, and productivity in development and manufacturing. Publish and share original research externally through peer-reviewed articles and conferences. Minimum Qualifications
B.S. in Chemical Engineering (0-12 years industry experience) or M.S. in Chemical Engineering (0-9 years industry experience). Additional Skills/Preferences
Strong technical skills in synthetic organic chemistry with hands-on laboratory experience. Prior experience in solid-phase and/or liquid-phase synthetic peptide and oligonucleotide processes is preferred but not required. Demonstrated problem-solving skills; strong verbal and written communication abilities; ability to collaborate in a team. Ability to prioritize multiple activities and handle ambiguity. Additional Information
Travel: 0 to 10%. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation. This is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer support networks for all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network, Lilly India Network, Organization of Latinx at Lilly, PRIDE, Veterans Leadership Network, Women’s Initiative for Leading at Lilly, enAble. Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $64,500 – $167,200 Full-time employees are eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits program to eligible employees, including a 401(k), pension, vacation, medical/dental/vision, flexible spending accounts, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its sole discretion. WeAreLilly #J-18808-Ljbffr
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people who are determined to make life better for others. Job Description: Synthetic Molecule Design and Development (SMDD) develops synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization. Our scientists and engineers provide technical and business solutions across the portfolio to accelerate testing of clinical hypotheses and drug development. SMDD values diverse talent and cultures to bring the next generation of medicines to patients. SMDD has an opportunity for an innovative chemical engineer to join the engineering group within its early phase TIDES (peptide and oligonucleotide) team. The engineer will join a cross-functional team developing synthetic peptide processes and facilitating technology transfer and scale-up to pilot plant, delivering product and process understanding across TIDES platforms. The early phase TIDES team develops synthesis processes to rapidly deliver pilot toxicology study materials for next generation therapeutic peptides. The engineer will gain experience with synthetic molecule unit operation design and data-rich experimentation to address synthesis challenges and advance peptide process development. Position Responsibilities
Generate process design and unit operation knowledge for small molecules, peptides, oligonucleotides, and other emerging therapeutic modalities. Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge. Design and execute laboratory experiments related to solid-phase and liquid-phase peptide and oligonucleotide synthesis, and downstream purification and isolation. Develop drug substance and manufacturing technologies. Provide creative solutions to improve existing processes and create novel ones. Transfer process technical information to internal pilot plant and provide technical oversight for pilot-scale GMP manufacturing activities. Author and maintain documentation such as laboratory notebooks and technical reports. Apply engineering and business principles to design and characterize synthetic processes. Use numerical modeling to analyze reaction kinetics, mechanisms, and separations. Design efficient process and equipment flow strategies, selecting appropriate equipment for each process. Stay informed about new technology and best practices; propose, justify, evaluate, and implement new equipment, processing techniques, and technologies. Utilize technology to improve safety, quality, and productivity in development and manufacturing. Publish and share original research externally through peer-reviewed articles and conferences. Minimum Qualifications
B.S. in Chemical Engineering (0-12 years industry experience) or M.S. in Chemical Engineering (0-9 years industry experience). Additional Skills/Preferences
Strong technical skills in synthetic organic chemistry with hands-on laboratory experience. Prior experience in solid-phase and/or liquid-phase synthetic peptide and oligonucleotide processes is preferred but not required. Demonstrated problem-solving skills; strong verbal and written communication abilities; ability to collaborate in a team. Ability to prioritize multiple activities and handle ambiguity. Additional Information
Travel: 0 to 10%. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation. This is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer support networks for all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network, Lilly India Network, Organization of Latinx at Lilly, PRIDE, Veterans Leadership Network, Women’s Initiative for Leading at Lilly, enAble. Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $64,500 – $167,200 Full-time employees are eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits program to eligible employees, including a 401(k), pension, vacation, medical/dental/vision, flexible spending accounts, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its sole discretion. WeAreLilly #J-18808-Ljbffr