Merck Gruppe - MSD Sharp & Dohme
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
Merck Gruppe - MSD Sharp & Dohme, West Point, Pennsylvania, us, 19486
Job Description
The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. Standard commute is less than 50 miles.
The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will be a key contributor to multi‑disciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.
Key Responsibilities
The principal responsibilities include working within teams of highly collaborative, cross‑functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities. The Principal Scientist will guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile. They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy. They will author source reports and documents in support of regulatory filings, evaluate and predict potential program risks, and implement appropriate strategies to address liabilities, ensuring efficient program progression and decision making. Qualifications
Education Minimum Requirement
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or related STEM fields. Required Experience and Skills
Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience in a relevant field, focusing on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates). Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, PK/PD and safety assessment studies, and dose justification for preclinical and clinical studies. Experience assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management. Experience authoring documents in support of IND, WMA filings, and responses to regulatory inquiries. Demonstrated track record as an effective collaborator on multi‑disciplinary discovery and development teams. Strong leadership, interpersonal, communication, problem‑solving, and collaboration skills, delivering results on firm deadlines. Preferred Experience and Skills
Strong publication track record. Experience representing the DMPK function in evaluation of third‑party assets. Experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP). Experience mentoring or supervising junior staff. Legal and Equal Opportunity
Merck is an Equal Employment Opportunity Employer; all qualified applicants receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status. All federal and state non‑discrimination laws apply. Hybrid Work Model (U.S.)
Effective September 5, 2023, U.S. employees in office‑based positions will work a hybrid model comprising three on‑site days per week (Monday‑Thursday variable) and one remote day. The model does not apply to field‑based, facility‑based, manufacturing or research positions, and positions requiring remote work may be designated fully remote. Compensation
Salary range: $169,700.00 – $267,200.00. Final salary based on education, experience, geographic location, and business needs. Eligible for annual bonus and long‑term incentives if applicable. Benefits
Comprehensive package including medical, dental, vision, retirement with 401(k), paid holidays, vacation, and sick days. Application and Contact
Apply through
https://jobs.merck.com/us/en
(or Workday Jobs Hub for current employees). Deadline stated on posting. Legal and Residency Information
San Francisco: Careers considered for applicants in compliance with the San Francisco Fair Chance Ordinance. Los Angeles: Applicants considered in compliance with the Los Angeles Fair Chance Initiative for Hiring Ordinance. Other Job Details
Employee status: Regular; Relocation: Domestic; VISA Sponsorship: Yes; Travel: 10%; Flexible Work Arrangements: Remote; Shift: Not Indicated; Valid Driving License: No; Hazardous Material: N/A; Job Posting End Date: 10/23/2025; Requisition ID: R369246.
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The principal responsibilities include working within teams of highly collaborative, cross‑functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities. The Principal Scientist will guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile. They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy. They will author source reports and documents in support of regulatory filings, evaluate and predict potential program risks, and implement appropriate strategies to address liabilities, ensuring efficient program progression and decision making. Qualifications
Education Minimum Requirement
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or related STEM fields. Required Experience and Skills
Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience in a relevant field, focusing on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates). Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, PK/PD and safety assessment studies, and dose justification for preclinical and clinical studies. Experience assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management. Experience authoring documents in support of IND, WMA filings, and responses to regulatory inquiries. Demonstrated track record as an effective collaborator on multi‑disciplinary discovery and development teams. Strong leadership, interpersonal, communication, problem‑solving, and collaboration skills, delivering results on firm deadlines. Preferred Experience and Skills
Strong publication track record. Experience representing the DMPK function in evaluation of third‑party assets. Experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP). Experience mentoring or supervising junior staff. Legal and Equal Opportunity
Merck is an Equal Employment Opportunity Employer; all qualified applicants receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status. All federal and state non‑discrimination laws apply. Hybrid Work Model (U.S.)
Effective September 5, 2023, U.S. employees in office‑based positions will work a hybrid model comprising three on‑site days per week (Monday‑Thursday variable) and one remote day. The model does not apply to field‑based, facility‑based, manufacturing or research positions, and positions requiring remote work may be designated fully remote. Compensation
Salary range: $169,700.00 – $267,200.00. Final salary based on education, experience, geographic location, and business needs. Eligible for annual bonus and long‑term incentives if applicable. Benefits
Comprehensive package including medical, dental, vision, retirement with 401(k), paid holidays, vacation, and sick days. Application and Contact
Apply through
https://jobs.merck.com/us/en
(or Workday Jobs Hub for current employees). Deadline stated on posting. Legal and Residency Information
San Francisco: Careers considered for applicants in compliance with the San Francisco Fair Chance Ordinance. Los Angeles: Applicants considered in compliance with the Los Angeles Fair Chance Initiative for Hiring Ordinance. Other Job Details
Employee status: Regular; Relocation: Domestic; VISA Sponsorship: Yes; Travel: 10%; Flexible Work Arrangements: Remote; Shift: Not Indicated; Valid Driving License: No; Hazardous Material: N/A; Job Posting End Date: 10/23/2025; Requisition ID: R369246.
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