Women In Bio
Director, Translational Genetics
Women In Bio, Collegeville, Pennsylvania, United States, 19426
Company Overview
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing. We are focused on accelerating assets that meet patients’ needs and have the highest probability of success. GSK kicked off 2025 with impressive growth in sales, profits, and earnings and anticipates five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. By uniting science, technology, and talent, we are committed to getting ahead of disease together. Job Purpose
We are seeking a highly experienced, motivated and innovative individual to join us as a Director in the Translational & Clinical Genetics team, part of the broader GSK Human Genetics and Genomics organisation. The successful candidate will provide strategic leadership and undertake hands‑on analyses to identify, develop and deliver a portfolio of translational data‑driven activities to impact the GSK portfolio. You will have strong expertise in genetics, with particular emphasis on causal inference approaches, and demonstrable experience of integrating genetics with genomics (especially proteomics) and clinical phenotypic data. Your work will have application across therapeutic areas and will inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches. The role includes leading a team of direct reports and working in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and leaders from a range of functions and external collaborators to advance drug discovery and clinical development. You will identify, establish and oversee collaborations with external institutions aligned with strategic priorities and be encouraged and supported in your ongoing scientific leadership development through presentations, publications, and stakeholder engagement. Key Responsibilities
Utilize deep expertise in statistical genetics and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to generate at‑scale insights and address targeted translational scientific questions. Provide strategic leadership and hands‑on analytical prowess to identify, develop, and deliver programs of work to impact the GSK drug development pipeline. Work within and lead cross‑functional GSK project teams, with an emphasis on respiratory, hepatology, neurodegeneration, immunology and/or renal disease. Identify, set up and oversee external scientific collaborations. Effectively communicate analysis findings, with expert interpretation, to project teams both within and outside the GSK Human Genetics & Genomics organisation. Work with focus and agility to deliver personal and team deliverables against objectives, demonstrating strong statistical, analytic and critical thinking skills with understanding of the translational context of your work. Stay informed about emerging technologies and methodologies in translational genetics and, in particular, causal inference approaches, with evaluation of their potential and implementation in the organization as indicated. Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning within the team. Basic Qualifications
PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with a history of impactful scientific publications and/or presentations. Extensive experience in genetics and conducting analyses that integrate genetics, genomics (particularly proteomics) and/or clinical phenotypic data to address translational questions in drug discovery and development. Expertise and leadership in genetic causal inference approaches (Mendelian randomization) with detailed understanding of emerging methodologies. Ability to drive the development and implementation of new methodologies and approaches to integrate genetics and genomics to answer translational questions in drug discovery and development. Demonstrated ability to understand key scientific questions and identify and develop innovative analytical solutions to answer them and impact the drug discovery pipeline. Strong proficiency in at least one of R and Python, with a track record of writing reproducible and scalable code that abides to FAIR principles. Experience of line management and supporting the professional development of team members. Demonstrated experience in effectively communicating complex scientific concepts to diverse audiences. Preferred Qualifications
Excellent collaboration and partnership skills to work effectively with internal stakeholders across functions. Experience of setting up and overseeing external collaborations. Experience of working in different trusted research environments (TREs). Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet project timelines. Familiarity with the stages of drug discovery and development. Why GSK
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines, focusing on respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients count on the medicines and vaccines we make, so we are committed to creating an environment where our people can thrive and focus on what matters most. Our culture of ambition for patients, accountability for impact and doing the right thing is the foundation of how we deliver for patients, shareholders and our people. Equal Opportunity Employer
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Adjustments Contact
If you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us at UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary. Employment Businesses / Agencies Notice
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. In the absence of such written authorization, any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit https://openpaymentsdata.cms.gov/.
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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing. We are focused on accelerating assets that meet patients’ needs and have the highest probability of success. GSK kicked off 2025 with impressive growth in sales, profits, and earnings and anticipates five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. By uniting science, technology, and talent, we are committed to getting ahead of disease together. Job Purpose
We are seeking a highly experienced, motivated and innovative individual to join us as a Director in the Translational & Clinical Genetics team, part of the broader GSK Human Genetics and Genomics organisation. The successful candidate will provide strategic leadership and undertake hands‑on analyses to identify, develop and deliver a portfolio of translational data‑driven activities to impact the GSK portfolio. You will have strong expertise in genetics, with particular emphasis on causal inference approaches, and demonstrable experience of integrating genetics with genomics (especially proteomics) and clinical phenotypic data. Your work will have application across therapeutic areas and will inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches. The role includes leading a team of direct reports and working in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and leaders from a range of functions and external collaborators to advance drug discovery and clinical development. You will identify, establish and oversee collaborations with external institutions aligned with strategic priorities and be encouraged and supported in your ongoing scientific leadership development through presentations, publications, and stakeholder engagement. Key Responsibilities
Utilize deep expertise in statistical genetics and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to generate at‑scale insights and address targeted translational scientific questions. Provide strategic leadership and hands‑on analytical prowess to identify, develop, and deliver programs of work to impact the GSK drug development pipeline. Work within and lead cross‑functional GSK project teams, with an emphasis on respiratory, hepatology, neurodegeneration, immunology and/or renal disease. Identify, set up and oversee external scientific collaborations. Effectively communicate analysis findings, with expert interpretation, to project teams both within and outside the GSK Human Genetics & Genomics organisation. Work with focus and agility to deliver personal and team deliverables against objectives, demonstrating strong statistical, analytic and critical thinking skills with understanding of the translational context of your work. Stay informed about emerging technologies and methodologies in translational genetics and, in particular, causal inference approaches, with evaluation of their potential and implementation in the organization as indicated. Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning within the team. Basic Qualifications
PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with a history of impactful scientific publications and/or presentations. Extensive experience in genetics and conducting analyses that integrate genetics, genomics (particularly proteomics) and/or clinical phenotypic data to address translational questions in drug discovery and development. Expertise and leadership in genetic causal inference approaches (Mendelian randomization) with detailed understanding of emerging methodologies. Ability to drive the development and implementation of new methodologies and approaches to integrate genetics and genomics to answer translational questions in drug discovery and development. Demonstrated ability to understand key scientific questions and identify and develop innovative analytical solutions to answer them and impact the drug discovery pipeline. Strong proficiency in at least one of R and Python, with a track record of writing reproducible and scalable code that abides to FAIR principles. Experience of line management and supporting the professional development of team members. Demonstrated experience in effectively communicating complex scientific concepts to diverse audiences. Preferred Qualifications
Excellent collaboration and partnership skills to work effectively with internal stakeholders across functions. Experience of setting up and overseeing external collaborations. Experience of working in different trusted research environments (TREs). Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet project timelines. Familiarity with the stages of drug discovery and development. Why GSK
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines, focusing on respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients count on the medicines and vaccines we make, so we are committed to creating an environment where our people can thrive and focus on what matters most. Our culture of ambition for patients, accountability for impact and doing the right thing is the foundation of how we deliver for patients, shareholders and our people. Equal Opportunity Employer
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Adjustments Contact
If you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us at UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary. Employment Businesses / Agencies Notice
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. In the absence of such written authorization, any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit https://openpaymentsdata.cms.gov/.
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