MD Anderson Cancer Center
Postdoctoral Fellow - Thoracic Head & Neck Medical Oncology
MD Anderson Cancer Center, Houston, Texas, United States, 77246
Overview
Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD, at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab investigates the molecular diversity of KRAS-mutant NSCLC and develops rational, tailored treatment strategies for patients with KRAS-mutant lung tumors. Research includes preclinical studies in immunocompetent co-mutational models of KRAS-mutant NSCLC, PDX/CDXs, in vitro models, and large collections of clinical specimens, complemented by computational biology/bioinformatics approaches to dissect responses to RAS inhibition. Applicants with experience in these areas and a passion for bench-to-bedside research are encouraged to apply and provide three professional references. Learning objectives Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas, Western blotting, ELISA, immunohistochemistry), in vitro assays (drug screening, flow cytometry, development of resistant cell lines), and in vivo experiments using xenograft, syngeneic, and genetically engineered mouse models of KRAS-mutant lung cancer. Candidates with prior experience in computational biology will analyze single-cell RNA sequencing, whole-exome sequencing, and in situ transcriptomics data. Trainees will present findings at lab meetings, departmental seminars, and national conferences, and submit findings for publication in peer-reviewed journals. Key requirements Eligibility: Applicants should have a PhD and/or MD and be interested in working in a translational research lab. The ideal candidate has less than 2 years of prior postdoctoral experience and a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting, and studies involving mouse models of KRAS-driven cancers, is preferred. Prior expertise in computational biology and bioinformatics, including analysis of single-cell RNA sequencing data and in situ transcriptomics, is desirable. Candidates should be innovative, highly motivated to pursue an independent career in biomedical research, and able to work collaboratively. Job knowledge and skills Enthusiastic, self-motivated candidate with the ability to work independently Strong background in cancer biology or cell and molecular biology; experience in RAS signaling/targeting preferred Computational biology/bioinformatics proficiency (Python/R) desirable but not essential Experience with mouse studies, including xenograft/syngeneic models and genetically engineered mice, preferred Commitment to basic research; team-oriented Excellent written and spoken English Prior publication record with at least one first-author manuscript Additional application information https://faculty.mdanderson.org/profiles/ferdinandos_skoulidis.html Position information MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000, depending on years of postgraduate experience. The University of Texas MD Anderson Cancer Center provides comprehensive benefits including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and recognition programs. Offsite work arrangements are subject to approval and may be modified or revoked based on business needs, performance considerations, or regulatory requirements. This position may involve maintaining the security and integrity of critical infrastructure and may require routine reviews and screening. Compliance with security requirements is a condition of hire and continued employment. Equal employment opportunity: The University of Texas MD Anderson Cancer Center provides equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other legally protected status. Seniority level Internship Employment type Full-time Job function Research Analyst Information Technology Industries Hospitals and Health Care
#J-18808-Ljbffr
Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD, at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab investigates the molecular diversity of KRAS-mutant NSCLC and develops rational, tailored treatment strategies for patients with KRAS-mutant lung tumors. Research includes preclinical studies in immunocompetent co-mutational models of KRAS-mutant NSCLC, PDX/CDXs, in vitro models, and large collections of clinical specimens, complemented by computational biology/bioinformatics approaches to dissect responses to RAS inhibition. Applicants with experience in these areas and a passion for bench-to-bedside research are encouraged to apply and provide three professional references. Learning objectives Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas, Western blotting, ELISA, immunohistochemistry), in vitro assays (drug screening, flow cytometry, development of resistant cell lines), and in vivo experiments using xenograft, syngeneic, and genetically engineered mouse models of KRAS-mutant lung cancer. Candidates with prior experience in computational biology will analyze single-cell RNA sequencing, whole-exome sequencing, and in situ transcriptomics data. Trainees will present findings at lab meetings, departmental seminars, and national conferences, and submit findings for publication in peer-reviewed journals. Key requirements Eligibility: Applicants should have a PhD and/or MD and be interested in working in a translational research lab. The ideal candidate has less than 2 years of prior postdoctoral experience and a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting, and studies involving mouse models of KRAS-driven cancers, is preferred. Prior expertise in computational biology and bioinformatics, including analysis of single-cell RNA sequencing data and in situ transcriptomics, is desirable. Candidates should be innovative, highly motivated to pursue an independent career in biomedical research, and able to work collaboratively. Job knowledge and skills Enthusiastic, self-motivated candidate with the ability to work independently Strong background in cancer biology or cell and molecular biology; experience in RAS signaling/targeting preferred Computational biology/bioinformatics proficiency (Python/R) desirable but not essential Experience with mouse studies, including xenograft/syngeneic models and genetically engineered mice, preferred Commitment to basic research; team-oriented Excellent written and spoken English Prior publication record with at least one first-author manuscript Additional application information https://faculty.mdanderson.org/profiles/ferdinandos_skoulidis.html Position information MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000, depending on years of postgraduate experience. The University of Texas MD Anderson Cancer Center provides comprehensive benefits including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and recognition programs. Offsite work arrangements are subject to approval and may be modified or revoked based on business needs, performance considerations, or regulatory requirements. This position may involve maintaining the security and integrity of critical infrastructure and may require routine reviews and screening. Compliance with security requirements is a condition of hire and continued employment. Equal employment opportunity: The University of Texas MD Anderson Cancer Center provides equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other legally protected status. Seniority level Internship Employment type Full-time Job function Research Analyst Information Technology Industries Hospitals and Health Care
#J-18808-Ljbffr