Takeda Pharmaceutical Company Limited
Research Associate Scientist, Immuno-Oncology Biology (ODDU)
Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, us, 02140
Job Description
Takeda Development Center Americas, Inc. is seeking a Research Associate Scientist, Immuno‑Oncology Biology (ODDU).
Position Description Responsibilities include:
Independently design and implement in vivo experiments focusing on efficacy, Pharmacokinetics (PK), and Mechanism of Action (MOA) studies in syngeneic, xenograft, and Patient Derived Xenograft (PDX) models.
Perform standard and complex in vivo procedures, including dosing all routes, tissue necropsy, and tumor inoculation and measurements.
Analyze, interpret, and present comprehensive technical or project data reports to key stakeholders, playing an active role in scientific discussions and decision‑making.
Collaborate externally with Contract Research Organizations (CROs) and establish new protocols.
Identify experimental protocols and in‑vivo models.
Conduct immunoassays, including flow cytometry, cytotoxicity assays, Meso Scale Discovery (MSD) assays, and Western blotting, as required.
Identify, plan, and execute well‑defined scientific projects with minimal supervision and deliver comprehensive high‑quality data sets to help decision‑making; communicate program strategy and timelines to management.
Maintain laboratory notebooks and follow laboratory practices in compliance.
Contribute to Investigational New Drug (IND) report and documentation.
Requirements
Master’s degree in Biotechnology, Animal Science, Biochemistry, Biology, or related field, plus 3 years of related experience, OR Bachelor’s degree in the same fields, plus 5 years of related experience.
Experience developing in vivo mouse models and executing in vivo animal work, including tumor inoculation (subcutaneous, intraperitoneal), T cell dose preparation and administration (intravenous), tumor measurement, tissue collection and ex vivo tissue processing.
Proficiency in multi‑color flow cytometry and data analysis of tumor tissues, tumor cell lines, and human T cells.
Experience conducting immunoassays including cytotoxicity assays, repeat stimulation assay, and MSD assay.
Ability to mentor, train, and assist team members in laboratory techniques and procedures.
Experience maintaining tumor cell lines (adherent/suspension) and human primary cell culture (thawing, culture, passaging, expression, sorting, harvesting and freezing).
Skill in DNA/RNA extraction and quantification using Polymerase Chain Reaction (PCR).
Knowledge of gel electrophoresis and DNA sequencing.
Location: Cambridge, MA
Remote work allowed up to 20%.
Employment type: Full time.
Salary: $108,800 to $179,600 per year.
Apply at https://jobs.takeda.com. Please reference job #R0165595.
EOE
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Position Description Responsibilities include:
Independently design and implement in vivo experiments focusing on efficacy, Pharmacokinetics (PK), and Mechanism of Action (MOA) studies in syngeneic, xenograft, and Patient Derived Xenograft (PDX) models.
Perform standard and complex in vivo procedures, including dosing all routes, tissue necropsy, and tumor inoculation and measurements.
Analyze, interpret, and present comprehensive technical or project data reports to key stakeholders, playing an active role in scientific discussions and decision‑making.
Collaborate externally with Contract Research Organizations (CROs) and establish new protocols.
Identify experimental protocols and in‑vivo models.
Conduct immunoassays, including flow cytometry, cytotoxicity assays, Meso Scale Discovery (MSD) assays, and Western blotting, as required.
Identify, plan, and execute well‑defined scientific projects with minimal supervision and deliver comprehensive high‑quality data sets to help decision‑making; communicate program strategy and timelines to management.
Maintain laboratory notebooks and follow laboratory practices in compliance.
Contribute to Investigational New Drug (IND) report and documentation.
Requirements
Master’s degree in Biotechnology, Animal Science, Biochemistry, Biology, or related field, plus 3 years of related experience, OR Bachelor’s degree in the same fields, plus 5 years of related experience.
Experience developing in vivo mouse models and executing in vivo animal work, including tumor inoculation (subcutaneous, intraperitoneal), T cell dose preparation and administration (intravenous), tumor measurement, tissue collection and ex vivo tissue processing.
Proficiency in multi‑color flow cytometry and data analysis of tumor tissues, tumor cell lines, and human T cells.
Experience conducting immunoassays including cytotoxicity assays, repeat stimulation assay, and MSD assay.
Ability to mentor, train, and assist team members in laboratory techniques and procedures.
Experience maintaining tumor cell lines (adherent/suspension) and human primary cell culture (thawing, culture, passaging, expression, sorting, harvesting and freezing).
Skill in DNA/RNA extraction and quantification using Polymerase Chain Reaction (PCR).
Knowledge of gel electrophoresis and DNA sequencing.
Location: Cambridge, MA
Remote work allowed up to 20%.
Employment type: Full time.
Salary: $108,800 to $179,600 per year.
Apply at https://jobs.takeda.com. Please reference job #R0165595.
EOE
#J-18808-Ljbffr