St. Jude Children's Research Hospital
Senior Bioinformatics Research Scientist
St. Jude Children's Research Hospital, Memphis, Tennessee, us, 37544
Senior Bioinformatics Research Scientist
Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children’s Research Hospital, where no child will die from the diseases we treat. The Computational and Structural Biology Center (CSBC) in the Center of Excellence for Data-Driven Discovery (C3D) of the Department of Structural Biology seeks a skilled and highly motivated Senior Bioinformatics Research Scientist. The CSBC acts as the collaborative interface of the C3D, working with St. Jude researchers campus‑wide to disseminate and implement the computational technologies developed by the C3D.
As a Senior Bioinformatics Research Scientist in the CSBC, you will play a pivotal role in the ligand discovery team, led by Dr. Christoph Gorgulla. You will be the first team member in the CSBC focused on ligand discovery, joining a team of dedicated computational researchers with expertise ranging from structural bioinformatics to machine learning and AI. Your primary mission will be to work with other groups and researchers across St. Jude to implement our technologies to identify novel hit/lead compounds for the treatment of various diseases. You will collaborate with teams to optimize results, obtaining new tool compounds and drug candidates. Leveraging state-of-the-art computational methods, including structure-based ultra‑large virtual screenings, quantum and classical free‑energy simulations, and machine‑learning techniques, you will contribute to groundbreaking research in the field. The primary ligand discovery platform we will use is the VirtualFlow ultra‑large virtual screening platform.
Additionally, the successful candidate will have the opportunity to lead collaborative projects, mentor junior scientists and students, and contribute to high-impact publications.
Job Responsibilities
Provide research support and deliver high-quality results by formulating efficient analytical approaches with the available data.
Deliver data files, document the analytical process, and may participate in manuscript preparation at the project's conclusion.
Assist with establishing and documenting protocols or best practices for common research tasks, and formulate analytical plans that use the best approach to address challenging data analysis questions.
Assist in the evaluation and testing of new methods and technologies.
Contribute ideas to automate or improve existing analysis methods; implement the improvement or work with others to do so.
Participate in the department’s developmental projects and interdepartmental team projects.
Perform other duties as assigned to meet the goals and objectives of the department and institution.
Maintain regular and predictable attendance.
Minimum Education and/or Training
Bachelor’s degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master’s degree or PhD preferred.
Minimum Experience
Minimum Requirement: Bachelor’s degree with 7+ years of relevant post‑degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master’s degree with 5+ years of relevant post‑degree experience (or) PhD with 2+ years of relevant post‑degree experience.
Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
Special Skills, Knowledge and Abilities
Optimizes data storage and minimizes intermediate data by reproducible computing.
Automates multiple cloud computing tasks.
Develops lightweight software applications with scripting languages (e.g., Perl, Python, Ruby) or programming languages (e.g., C++, Java).
Performs data modeling and database design to minimize redundancy and enforce relationships between different entities in relational databases.
Leads development, implementation, and maintenance of biomedical databases.
Coordinates data collection, database implementation, and usage.
Oversees QC on the data to be loaded into the database.
Works with IS to set up and install recommended software related to database collection.
Creates novel visualization to help data interpretation.
Leads evaluation and testing of new methods and technologies; contributes ideas to automate or improve existing analysis methods.
Establishes protocols or best practices for common research tasks and SOPs.
Leads evaluation of products and solutions, makes recommendations, and integrates solutions.
Leads computationally focused scientific research projects with minimal to moderate supervision.
Computational discovery of hit and lead compounds targeting proteins.
Uses structure-based virtual screens (of ultra‑large scale) using VirtualFlow, free‑energy simulations (quantum and classical), MD simulations, high‑performance computing, cloud computing, and machine‑learning‑based methods.
Predicts molecular properties of small molecules (using existing methods/software).
Identifies, processes, organizes, summarizes, reviews, and reports relevant data; manages molecular databases containing discovered hit and lead compounds.
Interacts and collaborates with wet lab scientists on drug discovery projects.
Interacts and collaborates with other computational colleagues.
Contributes to manuscript preparation.
Actively participates in independent research projects and collaborates with interdepartmental teams, fostering interdisciplinary approaches to solving complex scientific challenges.
Present research findings to internal and external audiences, contributing to the hospital’s mission of advancing pediatric research.
Compensation A reasonable estimate of the current salary range is $104,000 – $186,160 per year for the role of Senior Bioinformatics Research Scientist.
Benefits Explore our exceptional benefits!
Equal Opportunity Employer St. Jude is an Equal Opportunity Employer.
No Search Firms St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email.
#J-18808-Ljbffr
As a Senior Bioinformatics Research Scientist in the CSBC, you will play a pivotal role in the ligand discovery team, led by Dr. Christoph Gorgulla. You will be the first team member in the CSBC focused on ligand discovery, joining a team of dedicated computational researchers with expertise ranging from structural bioinformatics to machine learning and AI. Your primary mission will be to work with other groups and researchers across St. Jude to implement our technologies to identify novel hit/lead compounds for the treatment of various diseases. You will collaborate with teams to optimize results, obtaining new tool compounds and drug candidates. Leveraging state-of-the-art computational methods, including structure-based ultra‑large virtual screenings, quantum and classical free‑energy simulations, and machine‑learning techniques, you will contribute to groundbreaking research in the field. The primary ligand discovery platform we will use is the VirtualFlow ultra‑large virtual screening platform.
Additionally, the successful candidate will have the opportunity to lead collaborative projects, mentor junior scientists and students, and contribute to high-impact publications.
Job Responsibilities
Provide research support and deliver high-quality results by formulating efficient analytical approaches with the available data.
Deliver data files, document the analytical process, and may participate in manuscript preparation at the project's conclusion.
Assist with establishing and documenting protocols or best practices for common research tasks, and formulate analytical plans that use the best approach to address challenging data analysis questions.
Assist in the evaluation and testing of new methods and technologies.
Contribute ideas to automate or improve existing analysis methods; implement the improvement or work with others to do so.
Participate in the department’s developmental projects and interdepartmental team projects.
Perform other duties as assigned to meet the goals and objectives of the department and institution.
Maintain regular and predictable attendance.
Minimum Education and/or Training
Bachelor’s degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master’s degree or PhD preferred.
Minimum Experience
Minimum Requirement: Bachelor’s degree with 7+ years of relevant post‑degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master’s degree with 5+ years of relevant post‑degree experience (or) PhD with 2+ years of relevant post‑degree experience.
Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
Special Skills, Knowledge and Abilities
Optimizes data storage and minimizes intermediate data by reproducible computing.
Automates multiple cloud computing tasks.
Develops lightweight software applications with scripting languages (e.g., Perl, Python, Ruby) or programming languages (e.g., C++, Java).
Performs data modeling and database design to minimize redundancy and enforce relationships between different entities in relational databases.
Leads development, implementation, and maintenance of biomedical databases.
Coordinates data collection, database implementation, and usage.
Oversees QC on the data to be loaded into the database.
Works with IS to set up and install recommended software related to database collection.
Creates novel visualization to help data interpretation.
Leads evaluation and testing of new methods and technologies; contributes ideas to automate or improve existing analysis methods.
Establishes protocols or best practices for common research tasks and SOPs.
Leads evaluation of products and solutions, makes recommendations, and integrates solutions.
Leads computationally focused scientific research projects with minimal to moderate supervision.
Computational discovery of hit and lead compounds targeting proteins.
Uses structure-based virtual screens (of ultra‑large scale) using VirtualFlow, free‑energy simulations (quantum and classical), MD simulations, high‑performance computing, cloud computing, and machine‑learning‑based methods.
Predicts molecular properties of small molecules (using existing methods/software).
Identifies, processes, organizes, summarizes, reviews, and reports relevant data; manages molecular databases containing discovered hit and lead compounds.
Interacts and collaborates with wet lab scientists on drug discovery projects.
Interacts and collaborates with other computational colleagues.
Contributes to manuscript preparation.
Actively participates in independent research projects and collaborates with interdepartmental teams, fostering interdisciplinary approaches to solving complex scientific challenges.
Present research findings to internal and external audiences, contributing to the hospital’s mission of advancing pediatric research.
Compensation A reasonable estimate of the current salary range is $104,000 – $186,160 per year for the role of Senior Bioinformatics Research Scientist.
Benefits Explore our exceptional benefits!
Equal Opportunity Employer St. Jude is an Equal Opportunity Employer.
No Search Firms St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email.
#J-18808-Ljbffr