BioSpace
Scientific Associate Director - PKDM (Small Molecule ADME)
BioSpace, South San Francisco, California, us, 94083
Overview
Scientific Associate Director - PKDM (Small Molecule ADME)
role at BioSpace. This position oversees biotransformation activities and serves as a project team representative focused on small molecule programs, characterizing ADME/PK properties to optimize preclinical decisions. What You Will Do
Serve as a subject matter expert in small molecule biotransformation and lead biotransformation activities to support programs and develop strategies to reduce/mitigate metabolism-related risks. Leverage current biotransformation knowledge and develop/implement novel tools to efficiently support biotransformation activities. Act as a functional PKDM project team representative (PTR) and SME on the ADME/PK of small molecule therapeutics, collaborating with scientists across the PKDM community. Apply specialized ADME/PK skills (in vitro ADME, in vivo ADME, biotransformation, PK/PD, PBPK) to impact project progression and decision-making. Plan and execute mechanistic ADME/PK analyses to integrate drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics to optimize dose selection and preclinical study designs. Contribute to analysis of pre-clinical ADME and PK data for IND/NDA filings and document analyses in appropriate reports. Build close relationships with partner functions and therapeutic areas. What We Expect of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications. Basic Qualifications
Doctorate degree (PhD or PharmD or MD) and 4 years of directly related experience Or Masters degree and 7 years of directly related experience Or Bachelors degree and 9 years of directly related experience Preferred Qualifications
PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with 10+ years of experience in Biotech/Pharmaceutical Industry, consulting or post-doctoral training Solid technical experience applying SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects Ability to drive progression of SM discovery and development within project teams Establish SM biotransformation and ADME workflows for PKDM scientists Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK Experience supporting preclinical components of regulatory documentations Excellent interpersonal, technical, and communication skills to lead cross-functional teams Past experience as a laboratory scientist in a pharma or biotech environment Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills Record of scientific contributions through peer-reviewed articles and external presentations What You Can Expect From Us
We support your professional and personal growth and well-being with a collaborative culture and competitive benefits. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted; actual salary will vary based on skills, experience, and qualifications. In addition to base salary, Amgen offers a Total Rewards Plan including health and welfare plans, retirement savings, work-life balance, and career development opportunities. This may include: A comprehensive benefits package with retirement and savings plan, group medical/dental/vision, life and disability insurance, and flexible spending accounts A discretionary annual bonus program or field sales incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid options where possible Apply now and make a lasting impact with the Amgen team. For accommodations during the application process, contact us. Equal Opportunity and Accessibility
Amgen is an Equal Opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by law. We provide reasonable accommodations to participate in the job application or interview process upon request.
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Scientific Associate Director - PKDM (Small Molecule ADME)
role at BioSpace. This position oversees biotransformation activities and serves as a project team representative focused on small molecule programs, characterizing ADME/PK properties to optimize preclinical decisions. What You Will Do
Serve as a subject matter expert in small molecule biotransformation and lead biotransformation activities to support programs and develop strategies to reduce/mitigate metabolism-related risks. Leverage current biotransformation knowledge and develop/implement novel tools to efficiently support biotransformation activities. Act as a functional PKDM project team representative (PTR) and SME on the ADME/PK of small molecule therapeutics, collaborating with scientists across the PKDM community. Apply specialized ADME/PK skills (in vitro ADME, in vivo ADME, biotransformation, PK/PD, PBPK) to impact project progression and decision-making. Plan and execute mechanistic ADME/PK analyses to integrate drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics to optimize dose selection and preclinical study designs. Contribute to analysis of pre-clinical ADME and PK data for IND/NDA filings and document analyses in appropriate reports. Build close relationships with partner functions and therapeutic areas. What We Expect of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications. Basic Qualifications
Doctorate degree (PhD or PharmD or MD) and 4 years of directly related experience Or Masters degree and 7 years of directly related experience Or Bachelors degree and 9 years of directly related experience Preferred Qualifications
PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with 10+ years of experience in Biotech/Pharmaceutical Industry, consulting or post-doctoral training Solid technical experience applying SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects Ability to drive progression of SM discovery and development within project teams Establish SM biotransformation and ADME workflows for PKDM scientists Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK Experience supporting preclinical components of regulatory documentations Excellent interpersonal, technical, and communication skills to lead cross-functional teams Past experience as a laboratory scientist in a pharma or biotech environment Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills Record of scientific contributions through peer-reviewed articles and external presentations What You Can Expect From Us
We support your professional and personal growth and well-being with a collaborative culture and competitive benefits. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted; actual salary will vary based on skills, experience, and qualifications. In addition to base salary, Amgen offers a Total Rewards Plan including health and welfare plans, retirement savings, work-life balance, and career development opportunities. This may include: A comprehensive benefits package with retirement and savings plan, group medical/dental/vision, life and disability insurance, and flexible spending accounts A discretionary annual bonus program or field sales incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid options where possible Apply now and make a lasting impact with the Amgen team. For accommodations during the application process, contact us. Equal Opportunity and Accessibility
Amgen is an Equal Opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by law. We provide reasonable accommodations to participate in the job application or interview process upon request.
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