University of Michigan - Ann Arbor
Overview
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
NOTE: This position is term-limited for four (4) months
The Mosalaganti lab at the University of Michigan is seeking a Research Investigator to join the team and continue working on establishing faithful in vitro models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will leverage these models to recapitulate and investigate disease-associated patterns of protein aggregation, uncovering basic mechanisms of disease and paving the way for new biomarkers.
The work will be carried out together with the Barmada lab, which has a long-standing interest in delineating the molecular underpinnings of ALS and FTD through a combination of neuroscience, molecular biology, genome engineering, longitudinal microscopy, and stem cell biology. In a complementary fashion, the Mosalaganti lab uses cryo-electron tomography, correlative light and electron microscopy approaches to elucidate the structure of disease-related protein complexes in situ.
As a Research Investigator, you will have unencumbered access to equipment and microscopes located in the Department of Neurology and at the Life Sciences Institute, including a Leica Stellaris cryo-confocal, an Aquilos2, a Titan Krios G4i (with K3, Bioquantum imaging filter, and phase plate), and an Oxford Nanoimager. You will report directly to Drs. Mosalaganti and Barmada and will work fully onsite.
Queries regarding the project must be directed to mosalaga@umich.edu.
Experimental responsibilities
Culture, maintenance, and differentiation of human induced pluripotent stem cells
PCR and quantitative reverse transcriptase (qRT)-PCR
Molecular cloning
Genome editing (i.e., CRISPR/Cas9)
Immunostaining
Western blotting
Quantitative data analysis of microscopy data
Cryo-correlative light and electron microscopy, cryo-focused ion beam milling and cryo-electron tomography data collection and analysis
Writing and submitting manuscripts
Non-experimental responsibilities
Provide consultation and advice to lab members in areas of expertise
Maintain clear laboratory notebooks
Provide detailed documentation so experiments can be replicated
Follow laboratory best practices for safety and quality
Help manage projects
Assist PI in preparing manuscripts and grants
Qualifications
Ph.D. in molecular biology, cell biology, biochemistry, biophysics, or related discipline
Minimum 5 years of postdoctoral work experience
Minimum 4 years experience in cell and molecular biology techniques, including confocal microscopy, cryo-fluorescence microscopy, cryo-focused ion beam milling, and cryo-electron tomography data collection and analysis
Minimum 3 years experience in handling and differentiation of induced pluripotent stem cells into neurons
Minimum 3 years experience in handling iNeurons
Strong publication record in relevant work
Prior experience working in a collaborative environment
Minimum 2 years experience in light microscopy and tomography data analysis
Benefits Benefits at the University of Michigan
In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:
A retirement plan that provides two-for-one matching contributions
Many choices for comprehensive health insurance
Dental and Vision Insurance
Life insurance
Long-term disability coverage
Flexible spending accounts for healthcare and dependent care expenses
Maternity and Parental Leave
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checksare performed in compliance with the Fair Credit Reporting Act.
The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale. With a diverse community of inquisitive minds and exceptional tools, we are a catalyst for breakthrough discoveries.
For more information on the Mosalaganti lab: Life Sciences Institute
All applications for this position must be received by Thursday November 6th, 2025 by 11:59p.
The University of Michigan is an equal employment opportunity employer.
#J-18808-Ljbffr
NOTE: This position is term-limited for four (4) months
The Mosalaganti lab at the University of Michigan is seeking a Research Investigator to join the team and continue working on establishing faithful in vitro models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will leverage these models to recapitulate and investigate disease-associated patterns of protein aggregation, uncovering basic mechanisms of disease and paving the way for new biomarkers.
The work will be carried out together with the Barmada lab, which has a long-standing interest in delineating the molecular underpinnings of ALS and FTD through a combination of neuroscience, molecular biology, genome engineering, longitudinal microscopy, and stem cell biology. In a complementary fashion, the Mosalaganti lab uses cryo-electron tomography, correlative light and electron microscopy approaches to elucidate the structure of disease-related protein complexes in situ.
As a Research Investigator, you will have unencumbered access to equipment and microscopes located in the Department of Neurology and at the Life Sciences Institute, including a Leica Stellaris cryo-confocal, an Aquilos2, a Titan Krios G4i (with K3, Bioquantum imaging filter, and phase plate), and an Oxford Nanoimager. You will report directly to Drs. Mosalaganti and Barmada and will work fully onsite.
Queries regarding the project must be directed to mosalaga@umich.edu.
Experimental responsibilities
Culture, maintenance, and differentiation of human induced pluripotent stem cells
PCR and quantitative reverse transcriptase (qRT)-PCR
Molecular cloning
Genome editing (i.e., CRISPR/Cas9)
Immunostaining
Western blotting
Quantitative data analysis of microscopy data
Cryo-correlative light and electron microscopy, cryo-focused ion beam milling and cryo-electron tomography data collection and analysis
Writing and submitting manuscripts
Non-experimental responsibilities
Provide consultation and advice to lab members in areas of expertise
Maintain clear laboratory notebooks
Provide detailed documentation so experiments can be replicated
Follow laboratory best practices for safety and quality
Help manage projects
Assist PI in preparing manuscripts and grants
Qualifications
Ph.D. in molecular biology, cell biology, biochemistry, biophysics, or related discipline
Minimum 5 years of postdoctoral work experience
Minimum 4 years experience in cell and molecular biology techniques, including confocal microscopy, cryo-fluorescence microscopy, cryo-focused ion beam milling, and cryo-electron tomography data collection and analysis
Minimum 3 years experience in handling and differentiation of induced pluripotent stem cells into neurons
Minimum 3 years experience in handling iNeurons
Strong publication record in relevant work
Prior experience working in a collaborative environment
Minimum 2 years experience in light microscopy and tomography data analysis
Benefits Benefits at the University of Michigan
In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:
A retirement plan that provides two-for-one matching contributions
Many choices for comprehensive health insurance
Dental and Vision Insurance
Life insurance
Long-term disability coverage
Flexible spending accounts for healthcare and dependent care expenses
Maternity and Parental Leave
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checksare performed in compliance with the Fair Credit Reporting Act.
The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale. With a diverse community of inquisitive minds and exceptional tools, we are a catalyst for breakthrough discoveries.
For more information on the Mosalaganti lab: Life Sciences Institute
All applications for this position must be received by Thursday November 6th, 2025 by 11:59p.
The University of Michigan is an equal employment opportunity employer.
#J-18808-Ljbffr