St. Jude Children's Research Hospital
Lead or Senior Researcher - Babu Lab
St. Jude Children's Research Hospital, Memphis, Tennessee, us, 37544
Overview
As a part of the Center of Excellence for Data-Driven Discovery in the Department of Structural Biology at St. Jude Children’s Research Hospital, the Babu Group seeks a highly driven, full-time experimental Senior or Lead Researcher with a strong background in molecular biology and mammalian cell culture techniques to support the GPCR Collaborative. The GPCR Collaborative is a recently established St Jude-funded national collaborative between six leading GPCR biology and pharmacology experts to reveal the molecular determinants and fidelity of GPCR signaling in health and disease. The goal is to gain fundamentally new insights into GPCR physiology using state-of-the-art technologies that shift focus from time-averaged, ensemble investigations towards understanding the properties and functions of single molecules and assemblies in space and time. This will be accomplished by leveraging the different expertise of the Collaborative members: M. Madan Babu, Scott Blanchard, Jonathan Javitch, Robert Lefkowitz, Georgios Skiniotis, and Alice Ting.
The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases. The Researcher/Senior Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. Work from our group has revealed insights into signaling mechanisms and GPCR biology in multiple high-profile publications. This is a support role. The successful candidate will be a fast learner who can operate independently with care and confidence to support day-to-day experimental efforts in the Group. This role is appropriate for a candidate holding a Master’s degree and varying degrees of experience, up to a recent PhD. They will provide research support, perform experiments with guidance, and oversee supply inventorying, ordering, and receiving. Successful candidates will have experience making media preparations, performing standard molecular cloning procedures, and handling mammalian cell lines. Excellent organization and communication skills are required to document experimental observations, present results, and coordinate materials for multiple experimentalists in the group. A large component of the weekly responsibilities will be: 1) maintaining mammalian cell culture lines to support high-throughput assays to interrogate GPCR signaling and 2) maintaining, ordering, and organizing laboratory equipment and supplies. In this position, the candidate will gain extensive experience in cutting-edge techniques to interrogate the biology, structure, and pharmacology of GPCRs, the single most medicinally important protein family.
Responsibilities
Maintaining mammalian cell culture lines and preparing lines for testing and various experiments under the supervision of senior Scientists
Maintaining, ordering, and organizing laboratory supplies under the supervision of the Director of Scientific Operations and Manager
Performing GPCR signaling and biosensor assays in fluorescence and luminescence modes, using plate readers, flow cytometers, and microscopes
Molecular cloning of single constructs and DNA libraries using modern assembly techniques
Operating and maintaining laboratory equipment
Meticulous electronic documentation of experimental observations, procedures, sample organization, and results
Opportunities for Professional Growth
The candidate will learn to analyze cellular phenotypes using fluorescence microscopy and flow cytometric analysis
The candidate will learn how to genetically engineer mammalian cell lines
The candidate will learn to use fluorescence- and luminescence-based biosensor and reporter assays to interrogate GPCR signaling
St Jude Employees receive:
Excellent healthcare plans with zero to low health premium costs
Onsite health clinic, pharmacy, and exercise facilities
Paid parental leave and adoption assistance
Immigration Services
Tuition Reimbursement
The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
Minimum Education and/or Training for Either level
Bachelor’s degree in a relevant scientific area is required.
Minimum Experience for Senior Researcher
2+ years of research experience is required with a Bachelor's degree.
No prior experience required with a Master’s degree.
Minimum Experience for Lead Researcher
5+ years of research experience is required with a Bachelor's degree.
3+ years of experience is required with a Master’s degree.
No prior experience required with a PhD.
Salary and Compensation Salary Expectations:
A reasonable estimate of the current salary range is $54,038 - $89,148 per year for the role of Senior Researcher.
A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead Researcher.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead or Senior Researcher - Babu Lab.
Explore our exceptional benefits!
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
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The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases. The Researcher/Senior Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. Work from our group has revealed insights into signaling mechanisms and GPCR biology in multiple high-profile publications. This is a support role. The successful candidate will be a fast learner who can operate independently with care and confidence to support day-to-day experimental efforts in the Group. This role is appropriate for a candidate holding a Master’s degree and varying degrees of experience, up to a recent PhD. They will provide research support, perform experiments with guidance, and oversee supply inventorying, ordering, and receiving. Successful candidates will have experience making media preparations, performing standard molecular cloning procedures, and handling mammalian cell lines. Excellent organization and communication skills are required to document experimental observations, present results, and coordinate materials for multiple experimentalists in the group. A large component of the weekly responsibilities will be: 1) maintaining mammalian cell culture lines to support high-throughput assays to interrogate GPCR signaling and 2) maintaining, ordering, and organizing laboratory equipment and supplies. In this position, the candidate will gain extensive experience in cutting-edge techniques to interrogate the biology, structure, and pharmacology of GPCRs, the single most medicinally important protein family.
Responsibilities
Maintaining mammalian cell culture lines and preparing lines for testing and various experiments under the supervision of senior Scientists
Maintaining, ordering, and organizing laboratory supplies under the supervision of the Director of Scientific Operations and Manager
Performing GPCR signaling and biosensor assays in fluorescence and luminescence modes, using plate readers, flow cytometers, and microscopes
Molecular cloning of single constructs and DNA libraries using modern assembly techniques
Operating and maintaining laboratory equipment
Meticulous electronic documentation of experimental observations, procedures, sample organization, and results
Opportunities for Professional Growth
The candidate will learn to analyze cellular phenotypes using fluorescence microscopy and flow cytometric analysis
The candidate will learn how to genetically engineer mammalian cell lines
The candidate will learn to use fluorescence- and luminescence-based biosensor and reporter assays to interrogate GPCR signaling
St Jude Employees receive:
Excellent healthcare plans with zero to low health premium costs
Onsite health clinic, pharmacy, and exercise facilities
Paid parental leave and adoption assistance
Immigration Services
Tuition Reimbursement
The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
Minimum Education and/or Training for Either level
Bachelor’s degree in a relevant scientific area is required.
Minimum Experience for Senior Researcher
2+ years of research experience is required with a Bachelor's degree.
No prior experience required with a Master’s degree.
Minimum Experience for Lead Researcher
5+ years of research experience is required with a Bachelor's degree.
3+ years of experience is required with a Master’s degree.
No prior experience required with a PhD.
Salary and Compensation Salary Expectations:
A reasonable estimate of the current salary range is $54,038 - $89,148 per year for the role of Senior Researcher.
A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead Researcher.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead or Senior Researcher - Babu Lab.
Explore our exceptional benefits!
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
#J-18808-Ljbffr