Obsidian Therapeutics
Associate Scientist, Analytical Development
Obsidian Therapeutics, Bedford, Massachusetts, us, 01730
Associate Scientist, Analytical Development
Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our CytoDrive™ technology in cell and gene therapy products to control the expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in preclinical development for the treatment of patients with metastatic melanoma and other solid tumors.
We’re proud of our diverse, talented team and are committed to cultivating an inclusive environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and the Technical Operations team is based in our brand‑new facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
Our Opportunity Your role is to help drive the development of multiple cell therapy products in our pipeline targeting cancer. As part of the Technical Operations department, you will be a vital part of a highly collaborative team working to achieve Obsidian’s vision by translating innovative science into medical breakthroughs, starting with our lead program cytoTIL15 engineered to make TILs more effective for more patients.
You Will
Train on and skillfully execute analytical methods to support characterization studies of iFeeder starting materials and cell therapy products for late‑phase clinical trials.
Help design and execute experiments in collaboration with the process development team to support critical material characterization.
Author and review technical documents and data presentation, including study protocols, reports and test methods.
Interact with CDMO partners and serve as analytical PIP (person in plant), providing technical expertise and on‑site support as needed.
Maintain excellent records of experiments, including timely electronic notebook entries.
Collaborate well across the Obsidian organization and with external partners.
Present experimental designs, data packages, and proposed timelines to project teams, management, and scientific teams.
Perform work with limited direction following established procedures and an understanding of the underlying science.
You Bring Core Qualifications
MS with 3+ years or BS with 5+ years of relevant industry experience (degree in a relevant field such as biochemistry, cell biology, engineering, immunology).
Experience in product release and characterization methods for cell and gene therapy products with a focus on long‑term cell–based assays, excellent aseptic technique, molecular and immunoassays (PCR / qPCR, ddPCR, ELISA, MSD), flow cytometry.
Excellent organizational skills and the ability to manage multiple responsibilities in parallel, and communicate and prioritize effectively to deliver results within established timelines.
Exceptional record‑keeping skills.
A highly collaborative working style.
Tenacity, resilience, and drive to achieve company goals.
Self‑motivation and a proven ability to work with general direction to meet objectives and timelines, seeking clarity and support where needed.
Flexibility; a willingness and ability to adapt to changes in priorities in a fast‑paced, rapidly developing environment to advance our mission.
Scientific curiosity and pursuit of continuous learning.
Bonus Qualifications
Experience with multi‑parameter flow cytometry assays.
Demonstrated track record with analytical development supporting late‑stage development of biologics and/or cell therapies.
Experience with analytical assay technical transfer and/or qualification.
Obsidian is committed to equitable and transparent pay practices. The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location.
Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long‑term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.
Anticipated Base Salary Range: $97,500—$119,000 USD.
Obsidian is proud to be an equal‑opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, or any other legally protected characteristics.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research, Analyst, and Information Technology
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We’re proud of our diverse, talented team and are committed to cultivating an inclusive environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and the Technical Operations team is based in our brand‑new facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
Our Opportunity Your role is to help drive the development of multiple cell therapy products in our pipeline targeting cancer. As part of the Technical Operations department, you will be a vital part of a highly collaborative team working to achieve Obsidian’s vision by translating innovative science into medical breakthroughs, starting with our lead program cytoTIL15 engineered to make TILs more effective for more patients.
You Will
Train on and skillfully execute analytical methods to support characterization studies of iFeeder starting materials and cell therapy products for late‑phase clinical trials.
Help design and execute experiments in collaboration with the process development team to support critical material characterization.
Author and review technical documents and data presentation, including study protocols, reports and test methods.
Interact with CDMO partners and serve as analytical PIP (person in plant), providing technical expertise and on‑site support as needed.
Maintain excellent records of experiments, including timely electronic notebook entries.
Collaborate well across the Obsidian organization and with external partners.
Present experimental designs, data packages, and proposed timelines to project teams, management, and scientific teams.
Perform work with limited direction following established procedures and an understanding of the underlying science.
You Bring Core Qualifications
MS with 3+ years or BS with 5+ years of relevant industry experience (degree in a relevant field such as biochemistry, cell biology, engineering, immunology).
Experience in product release and characterization methods for cell and gene therapy products with a focus on long‑term cell–based assays, excellent aseptic technique, molecular and immunoassays (PCR / qPCR, ddPCR, ELISA, MSD), flow cytometry.
Excellent organizational skills and the ability to manage multiple responsibilities in parallel, and communicate and prioritize effectively to deliver results within established timelines.
Exceptional record‑keeping skills.
A highly collaborative working style.
Tenacity, resilience, and drive to achieve company goals.
Self‑motivation and a proven ability to work with general direction to meet objectives and timelines, seeking clarity and support where needed.
Flexibility; a willingness and ability to adapt to changes in priorities in a fast‑paced, rapidly developing environment to advance our mission.
Scientific curiosity and pursuit of continuous learning.
Bonus Qualifications
Experience with multi‑parameter flow cytometry assays.
Demonstrated track record with analytical development supporting late‑stage development of biologics and/or cell therapies.
Experience with analytical assay technical transfer and/or qualification.
Obsidian is committed to equitable and transparent pay practices. The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location.
Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long‑term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.
Anticipated Base Salary Range: $97,500—$119,000 USD.
Obsidian is proud to be an equal‑opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, or any other legally protected characteristics.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research, Analyst, and Information Technology
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