University of California
We are seeking a highly motivated Postdoctoral Fellow to join our interdisciplinary team
developing cutting-edge preclinical and clinical technologies to quantify and therapeutically modulate synaptic stability and plasticity in the brain . This position offers a unique opportunity to bridge basic neuroscience with translational applications , leveraging advanced tools in transcranial focused ultrasound, neuroimaging, and biopharmaceuticals to drive innovation in brain disorder therapeutics. Key Responsibilities: Design and execute experiments to investigate synaptic plasticity, stability, and dysfunction in preclinical and/or clinical models. Develop and optimize
transcranialfocused ultrasound , neuroimaging (MRI/immuno-PET), and immunohistochemistry
for image-guided modulation of synaptic plasticity in targeted neural circuits. Data analysis
(with Python, MATLAB, or similar) to analyze neuroimaging datasets. Collaborate with clinicians, engineers, and computational neuroscientists to translate findings into novel therapeutic strategies. Publish high-impact research and present findings at international conferences. Why Join Us? Work with a highly interdisciplinary team with
a scholarly, collaborative, and rigorous lab culture with access to state-of-the-art facilities. Live in a vibrant city (SF) with beautiful nature and weather. Contribute to high-impact research with very exceptionally strong potential for clinical translation. Help advance neural circuit therapeutics that could lead to the first disease-modifying treatments for psychiatric illness like autism, schizophrenia, obsessive-compulsive disorder, and addiction. Strong emphasis on career development, grant writing, and mentorship . Competitive salary and benefits package. Job Requirements
Qualifications: PhD, MD, or MD/PhD in Neuroscience, Biomedical Engineering, or a related field Desires training to establish independence and lead research projects in academia or industry . Strong background in synaptic plasticity, neuroimaging, electrophysiology, or molecular neuroscience . Experience with quantitative data analysis (Python, MATLAB, R, or similar) is highly desirable. Interest in working with rodent models, in-human studies, or both Excellent written and verbal communication skills. How to Apply Please submit your CV to patti.limon at ucsf dot edu My lab’s overall goal is to implement image-guided transcranial focused ultrasound (FUS) technologies to rebalance synaptic stability and plasticity in the brain, as a treatment for disorders of excessive neural circuit stability including autism, OCD, Tourette, addiction, and PTSD. FUS has high spatial resolution (up to ~1 mm) that can be shaped to the target structure, can modulate neural activity through its impact on mechanosensitive ion channels, and can target biopharmaceuticals into the brain. My lab currently is advancing early-stage in-human studies using the visual system as a test-bed to optimize FUS neuromodulation, and we are organizing early-stage FUS clinical trials to ameliorate insistence on sameness symptoms in autism. Moreover, in preclinical models we use FUS-targeted biopharmaceuticals to modulate synaptic stability and normalize behavioral inflexibility in psychiatric disorders, in tandem with radioligand-conjugated engineered antibodies to quantify synaptic stability with immuno-PET/SPECT. This work is among the first attempts to pursue theranostics-inspired approaches for plasticity-rebalancing treatment in severe psychiatric illness. I have a K08 career development award, a SFARI Fellows-to-Faculty award, Deeda Blair Initiative award, BBRF Young Investigator award, and start-up funds to support these projects. I have more than a year of silent retreat experience in the Vipassana mediation tradition.
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developing cutting-edge preclinical and clinical technologies to quantify and therapeutically modulate synaptic stability and plasticity in the brain . This position offers a unique opportunity to bridge basic neuroscience with translational applications , leveraging advanced tools in transcranial focused ultrasound, neuroimaging, and biopharmaceuticals to drive innovation in brain disorder therapeutics. Key Responsibilities: Design and execute experiments to investigate synaptic plasticity, stability, and dysfunction in preclinical and/or clinical models. Develop and optimize
transcranialfocused ultrasound , neuroimaging (MRI/immuno-PET), and immunohistochemistry
for image-guided modulation of synaptic plasticity in targeted neural circuits. Data analysis
(with Python, MATLAB, or similar) to analyze neuroimaging datasets. Collaborate with clinicians, engineers, and computational neuroscientists to translate findings into novel therapeutic strategies. Publish high-impact research and present findings at international conferences. Why Join Us? Work with a highly interdisciplinary team with
a scholarly, collaborative, and rigorous lab culture with access to state-of-the-art facilities. Live in a vibrant city (SF) with beautiful nature and weather. Contribute to high-impact research with very exceptionally strong potential for clinical translation. Help advance neural circuit therapeutics that could lead to the first disease-modifying treatments for psychiatric illness like autism, schizophrenia, obsessive-compulsive disorder, and addiction. Strong emphasis on career development, grant writing, and mentorship . Competitive salary and benefits package. Job Requirements
Qualifications: PhD, MD, or MD/PhD in Neuroscience, Biomedical Engineering, or a related field Desires training to establish independence and lead research projects in academia or industry . Strong background in synaptic plasticity, neuroimaging, electrophysiology, or molecular neuroscience . Experience with quantitative data analysis (Python, MATLAB, R, or similar) is highly desirable. Interest in working with rodent models, in-human studies, or both Excellent written and verbal communication skills. How to Apply Please submit your CV to patti.limon at ucsf dot edu My lab’s overall goal is to implement image-guided transcranial focused ultrasound (FUS) technologies to rebalance synaptic stability and plasticity in the brain, as a treatment for disorders of excessive neural circuit stability including autism, OCD, Tourette, addiction, and PTSD. FUS has high spatial resolution (up to ~1 mm) that can be shaped to the target structure, can modulate neural activity through its impact on mechanosensitive ion channels, and can target biopharmaceuticals into the brain. My lab currently is advancing early-stage in-human studies using the visual system as a test-bed to optimize FUS neuromodulation, and we are organizing early-stage FUS clinical trials to ameliorate insistence on sameness symptoms in autism. Moreover, in preclinical models we use FUS-targeted biopharmaceuticals to modulate synaptic stability and normalize behavioral inflexibility in psychiatric disorders, in tandem with radioligand-conjugated engineered antibodies to quantify synaptic stability with immuno-PET/SPECT. This work is among the first attempts to pursue theranostics-inspired approaches for plasticity-rebalancing treatment in severe psychiatric illness. I have a K08 career development award, a SFARI Fellows-to-Faculty award, Deeda Blair Initiative award, BBRF Young Investigator award, and start-up funds to support these projects. I have more than a year of silent retreat experience in the Vipassana mediation tradition.
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