St. Jude Children's Research Hospital
Wet Lab Scientist in Dr. Gorgulla Lab
St. Jude Children's Research Hospital, Memphis, Tennessee, us, 37544
Overview
Join an excellent team of researchers at St. Jude Children’s Research Hospital. The Computational and Structural Biology Center (CSBC) within the Center of Excellence for Data-Driven Discovery (C3D) of the Department of Structural Biology seeks a skilled Senior Bioinformatics Research Scientist or Senior Computational Researcher to contribute to ligand discovery and drug development efforts.
You will join the ligand discovery team led by Dr. Christoph Gorgulla as the first CSBC member focused on ligand discovery. Collaborating with computational researchers spanning structural bioinformatics, machine learning, and AI, your primary mission is to work with St. Jude groups to implement technologies that identify novel hit/lead compounds for treating various diseases. You will optimize results, work toward new tool compounds and drug candidates, and leverage state-of-the-art computational methods, including structure-based ultra-large virtual screenings, quantum and classical free energy simulations, and machine-learning techniques. The primary ligand discovery platform used will be the VirtualFlow ultra-large virtual screening platform.
Responsibilities
Independently perform basic and advanced statistical analysis, implement algorithms, program across biotechnology platforms, and oversee quality checks.
Design and prepare materials and courses for training on bioinformatics software, databases, computing, data mining, and analysis.
Act as a liaison between end-users, software developers, system designers, and different departments.
Establish protocols or SOPs, evaluate products and solutions, make recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection and related hardware/software.
Develop programs to assist in data analysis within databases.
Assist in planning, coordinating, and organizing projects across departments; delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet department and institutional goals.
Maintain regular and predictable attendance.
Qualifications Minimum Education and/or Training:
Bachelor’s degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master’s degree or PhD preferred.
Minimum Experience:
Minimum Requirement: Bachelor’s degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master’s degree with 4+ years of relevant post-degree experience (OR) PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package, with R preferred.
About St. Jude St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. It is an NCI-designated Comprehensive Cancer Center devoted solely to children. Our faculty collaborate across basic, translational, clinical, and population science in a multidisciplinary environment. St. Jude is recognized for workplace excellence.
What We Will Offer You Working at St. Jude is a remarkable experience with many perks.
Mission and Purpose:
Working at St. Jude is a calling. You will be part of a shared mission to find cures and save children, along with comprehensive perks to support you.
Community and Belonging:
A welcoming, family-like environment within a pediatric hospital.
The Best of Both Worlds – Industry and Academia:
Academic freedom in research with industrial resources and funding, plus access to world-class facilities and technology.
World-Class Benefits:
Comprehensive healthcare, competitive salary, tuition assistance, and strong work-life balance.
Professional Growth:
Opportunities to enhance scientific and soft skills and a defined career path.
Diversity:
Commitment to an inclusive and diverse scientific community.
Competitive Compensation:
Competitive salary, comprehensive benefits, and relocation assistance where applicable.
Top Employer:
Recognition for being a leading employer in various rankings.
Personalized Guidance:
Mentorship to support your scientific and career development.
Modern Facilities:
Access to modern buildings and spaces for research and collaboration.
Additional Perks:
On-site amenities and other workplace perks.
About Memphis St. Jude is located in Memphis, Tennessee. Memphis offers diverse cultural experiences, affordability, and access to nature and arts. Living in Memphis provides several advantages for employees and families.
For more on Memphis and relocation experiences, please refer to internal resources.
Compensation In recognition of pay transparency laws, St. Jude provides a reasonable estimate of the compensation range for this role. The current estimated salary range is $78,000 – $139,360 per year for the Bioinformatics Research Scientist or Senior Computational Researcher role. This estimate is non-binding and may be adjusted based on experience, education, and other factors.
St. Jude is an Equal Opportunity Employer. No search firms.
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You will join the ligand discovery team led by Dr. Christoph Gorgulla as the first CSBC member focused on ligand discovery. Collaborating with computational researchers spanning structural bioinformatics, machine learning, and AI, your primary mission is to work with St. Jude groups to implement technologies that identify novel hit/lead compounds for treating various diseases. You will optimize results, work toward new tool compounds and drug candidates, and leverage state-of-the-art computational methods, including structure-based ultra-large virtual screenings, quantum and classical free energy simulations, and machine-learning techniques. The primary ligand discovery platform used will be the VirtualFlow ultra-large virtual screening platform.
Responsibilities
Independently perform basic and advanced statistical analysis, implement algorithms, program across biotechnology platforms, and oversee quality checks.
Design and prepare materials and courses for training on bioinformatics software, databases, computing, data mining, and analysis.
Act as a liaison between end-users, software developers, system designers, and different departments.
Establish protocols or SOPs, evaluate products and solutions, make recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection and related hardware/software.
Develop programs to assist in data analysis within databases.
Assist in planning, coordinating, and organizing projects across departments; delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet department and institutional goals.
Maintain regular and predictable attendance.
Qualifications Minimum Education and/or Training:
Bachelor’s degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master’s degree or PhD preferred.
Minimum Experience:
Minimum Requirement: Bachelor’s degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master’s degree with 4+ years of relevant post-degree experience (OR) PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package, with R preferred.
About St. Jude St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. It is an NCI-designated Comprehensive Cancer Center devoted solely to children. Our faculty collaborate across basic, translational, clinical, and population science in a multidisciplinary environment. St. Jude is recognized for workplace excellence.
What We Will Offer You Working at St. Jude is a remarkable experience with many perks.
Mission and Purpose:
Working at St. Jude is a calling. You will be part of a shared mission to find cures and save children, along with comprehensive perks to support you.
Community and Belonging:
A welcoming, family-like environment within a pediatric hospital.
The Best of Both Worlds – Industry and Academia:
Academic freedom in research with industrial resources and funding, plus access to world-class facilities and technology.
World-Class Benefits:
Comprehensive healthcare, competitive salary, tuition assistance, and strong work-life balance.
Professional Growth:
Opportunities to enhance scientific and soft skills and a defined career path.
Diversity:
Commitment to an inclusive and diverse scientific community.
Competitive Compensation:
Competitive salary, comprehensive benefits, and relocation assistance where applicable.
Top Employer:
Recognition for being a leading employer in various rankings.
Personalized Guidance:
Mentorship to support your scientific and career development.
Modern Facilities:
Access to modern buildings and spaces for research and collaboration.
Additional Perks:
On-site amenities and other workplace perks.
About Memphis St. Jude is located in Memphis, Tennessee. Memphis offers diverse cultural experiences, affordability, and access to nature and arts. Living in Memphis provides several advantages for employees and families.
For more on Memphis and relocation experiences, please refer to internal resources.
Compensation In recognition of pay transparency laws, St. Jude provides a reasonable estimate of the compensation range for this role. The current estimated salary range is $78,000 – $139,360 per year for the Bioinformatics Research Scientist or Senior Computational Researcher role. This estimate is non-binding and may be adjusted based on experience, education, and other factors.
St. Jude is an Equal Opportunity Employer. No search firms.
#J-18808-Ljbffr