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University of Missouri-Columbia

Scientist - Dr. Shirwan & Dr. Yolcu Laboratory

University of Missouri-Columbia, Columbia, Missouri, United States

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Overview

NextGen Precision Health at the University of Missouri seeks a Scientist to contribute to the Immunomodulation and Translational Research Program and the Department of Molecular Microbiology and Immunology. The research focuses on developing novel biologics and their targeted delivery for immunomodulation, aiming to prevent and treat immune-related disorders with emphasis on type 1 diabetes and cancer immunotherapy and immunoprevention. The role involves islet transplantation research for Type 1 Diabetes using rodent and humanized mouse models. The successful candidate will develop, execute, and evaluate experiments to assess the immunomodulatory efficacy of select biologics for various applications, contribute to data analysis, and support grant and manuscript submissions. Collaboration and mentorship of graduate students and technical personnel are expected. Key Responsibilities

Perform advanced microsurgical procedures, including islet isolation and transplantation in small animal models. Design and execute experiments to evaluate graft function, immune tolerance, and rejection mechanisms. Conduct immunological assays including immunohistochemistry, multiparameter flow cytometry, and mixed lymphocyte reactions. Analyze and interpret complex datasets; contribute to manuscript preparation and grant proposals. Maintain detailed records and ensure compliance with institutional and federal animal care regulations. Train and mentor graduate students and technical staff in microsurgical and immunological techniques. We seek a self-motivated, detail-oriented, and goal-driven researcher with strong creative and critical thinking skills and the ability to work well in a multidisciplinary team. Qualifications

Minimum Qualifications:

A Bachelor's degree in a related/relevant area and at least 3 years of experience from which comparable knowledge and skills can be acquired are necessary. Preferred Qualifications: Ph.D., M.D., or equivalent in a relevant biomedical field. Demonstrated expertise in microsurgery, particularly in islet transplantation techniques. Proficiency in rodent and/or humanized mouse models. Hands-on experience with immunohistochemistry, flow cytometry, and lymphocyte functional assays. Strong critical thinking, problem-solving, and data analysis skills. Excellent communication and organizational abilities. Ability to work effectively in a multidisciplinary team environment. Shift

Monday - Friday, 8:00 a.m. - 5:00 p.m. Anticipated Hiring Range

Salary Range: $52,915.20 - $74,484.80 per year Grade: GGS-010 University Title: Scientist Internal applicants can determine their University title by accessing the Talent Profile tile in myHR. Application Materials

Application, CV, References Other Information

Why Join Us?

This is a unique opportunity to contribute to transformative research with the potential to improve outcomes for individuals with Type 1 Diabetes. You will join a collaborative, forward-thinking team at the University of Missouri, with access to state-of-the-art facilities through the NextGen Precision Health Institution. Columbia, Missouri:

Columbia, Mo., is known as an ideal college town, offering community, culture, and a relatively low cost of living with access to restaurants and entertainment venues and multiple annual cultural festivals. Benefit Eligibility:

This position is eligible for University benefits. The University offers a comprehensive benefits package as part of total compensation, including medical, dental and vision plans, retirement, paid time off, disability coverage, paid parental leave, paid caregiver leave, and educational fee discounts for all four UM System campuses. For more information, visit the Faculty & Staff Benefits website at https://www.umsystem.edu/totalrewards/benefits. Equal Employment Opportunity

The University of Missouri is an Equal Opportunity Employer. To request ADA accommodations, please contact the Director of Accessibility and ADA at 573-884-7278.

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