Alaka`ina Foundation Family of Companies
Senior Bacterial Core Technician
Alaka`ina Foundation Family of Companies, Frederick, Maryland, United States, 21701
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Senior Bacterial Core Technician
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Alaka`ina Foundation Family of Companies The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a
Senior Bacterial Core Technician
to support our government customer located in
Fort Detrick, Frederick, MD . DESCRIPTION OF RESPONSIBILITIES: Responsible for BSL-3 laboratory operations and training in animal manipulations. Technicians shall perform approximately 5 animal studies in both the DTRA funded projects as well as contracted work. Perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. Participate in mouse, rat, rabbit, or other small animal studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections. Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work. Participate in mouse, rat, rabbit, or other small animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection for pharmacokinetic or pharmacodynamic analyses. Support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads. Assist with data analyses and drafting reports for internal or external customers. Work with mass spectrometry, chromatography, HPLC MS/MS, specifically Sciex platforms coupled with Shimadzu HPLCs other and biophysical techniques to support in-process testing and characterization of biopharmaceutical products and impurities. Perform bioanalytical data acquisition, data analysis, and reporting of results using Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant. Complete approximately 25 media/reagent preparations per year. Assist with approximately 5 animal challenges per year and 10 bacterial challenge preparations. Perform approximately 400 animal injections per year; 400 animal observations per year. Support divisional in vivo projects by completing approximately 500 bacterial burdens in animal tissue per year. Perform approximately 500 small animal necropsies per year. Process approximately 300 animal gavage and approximately 125 animal blood collections per year. Place approximately 50 GFEBs orders per year for supplies and equipment. Maintain laboratories in BSL-2 and BSL-3. Perform or assist with BSAT Inventory Management weekly (to include applicable BSAT working stock material). Conduct or assist with Equipment Inventory Management twice a year in BSL-2 and BSL-3. Perform or assist with monthly Laboratory Management to include safety functions and chemical inventory. Review relevant literature monthly. Maintain a GLP training folder and be compliant with all GLP regulations when applicable. Directly contribute to the design, rationale, and be point-of-contact for 10 small animal studies to include drafting of a study plan and oversight of personnel scheduling. Contribute to study progress reports and scientific manuscripts to include statistical analysis, data compilation, figure preparation, and methods summary. Assist in establishing up to 28 new active material transfer agreements and cooperative research and development agreements with up to 8 pharmaceutical companies and/or universities. Other duties as assigned by Supervisor. REQUIRED DEGREE/EDUCATION/CERTIFICATION: Bachelor's degree in Biology, Microbiology or similar science and 5 years of relevant laboratory experience. REQUIRED SKILLS AND EXPERIENCE: Must have a minimum of two (2) to three (3) years performing BSL-3 laboratory operations and training in animal manipulations and conducting animal studies. Must have a minimum of two (2) to three (3) years performing in-vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. Must be willing to work with diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (meliodosis). Must have a minimum of three (3) to five (5) years conducting small animal studies (mouse, rat, rabbit, or other) which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections, collecting animal body fluids and removing of tissue samples Must have a minimum of two (2) to three (3) years’ experience working within IACUC approved protocols. Must have research experience in pharmacology, pharmacokinetics, and pharmacodynamics. Must have direct experience in in-process testing and characterization of biopharmaceutical products and impurities using mass spectrometry, chromatography, HPLC MS/MS. Must have a minimum of two (2) to three (3) years’ experience with Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant. Must have a minimum of two (2) to three (3) years performing Animal Necropsies, animal gavage and animal blood collections. Must have a minimum of two (2) to three (3) years performing Equipment Inventory Management. Must have a minimum of two (2) to three (3) years performing Laboratory Management within BSL-2 and BSL-3 environments, to include safety functions and chemical inventory. REQUIRED CITIZENSHIP AND CLEARANCE: U.S. Citizen BPRP and CS-PRP enrollment required. Must pass NACI background check. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees enjoy a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 11 paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. We are proud to state that we do not illegally discriminate in employment decisions on the basis of any protected categories. If you are a person with a disability and you need an accommodation during the application process, please request accommodation. We E-Verify all employees EOE, including Disability/Vets
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Senior Bacterial Core Technician
role at
Alaka`ina Foundation Family of Companies The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a
Senior Bacterial Core Technician
to support our government customer located in
Fort Detrick, Frederick, MD . DESCRIPTION OF RESPONSIBILITIES: Responsible for BSL-3 laboratory operations and training in animal manipulations. Technicians shall perform approximately 5 animal studies in both the DTRA funded projects as well as contracted work. Perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. Participate in mouse, rat, rabbit, or other small animal studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections. Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work. Participate in mouse, rat, rabbit, or other small animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection for pharmacokinetic or pharmacodynamic analyses. Support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads. Assist with data analyses and drafting reports for internal or external customers. Work with mass spectrometry, chromatography, HPLC MS/MS, specifically Sciex platforms coupled with Shimadzu HPLCs other and biophysical techniques to support in-process testing and characterization of biopharmaceutical products and impurities. Perform bioanalytical data acquisition, data analysis, and reporting of results using Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant. Complete approximately 25 media/reagent preparations per year. Assist with approximately 5 animal challenges per year and 10 bacterial challenge preparations. Perform approximately 400 animal injections per year; 400 animal observations per year. Support divisional in vivo projects by completing approximately 500 bacterial burdens in animal tissue per year. Perform approximately 500 small animal necropsies per year. Process approximately 300 animal gavage and approximately 125 animal blood collections per year. Place approximately 50 GFEBs orders per year for supplies and equipment. Maintain laboratories in BSL-2 and BSL-3. Perform or assist with BSAT Inventory Management weekly (to include applicable BSAT working stock material). Conduct or assist with Equipment Inventory Management twice a year in BSL-2 and BSL-3. Perform or assist with monthly Laboratory Management to include safety functions and chemical inventory. Review relevant literature monthly. Maintain a GLP training folder and be compliant with all GLP regulations when applicable. Directly contribute to the design, rationale, and be point-of-contact for 10 small animal studies to include drafting of a study plan and oversight of personnel scheduling. Contribute to study progress reports and scientific manuscripts to include statistical analysis, data compilation, figure preparation, and methods summary. Assist in establishing up to 28 new active material transfer agreements and cooperative research and development agreements with up to 8 pharmaceutical companies and/or universities. Other duties as assigned by Supervisor. REQUIRED DEGREE/EDUCATION/CERTIFICATION: Bachelor's degree in Biology, Microbiology or similar science and 5 years of relevant laboratory experience. REQUIRED SKILLS AND EXPERIENCE: Must have a minimum of two (2) to three (3) years performing BSL-3 laboratory operations and training in animal manipulations and conducting animal studies. Must have a minimum of two (2) to three (3) years performing in-vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. Must be willing to work with diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (meliodosis). Must have a minimum of three (3) to five (5) years conducting small animal studies (mouse, rat, rabbit, or other) which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections, collecting animal body fluids and removing of tissue samples Must have a minimum of two (2) to three (3) years’ experience working within IACUC approved protocols. Must have research experience in pharmacology, pharmacokinetics, and pharmacodynamics. Must have direct experience in in-process testing and characterization of biopharmaceutical products and impurities using mass spectrometry, chromatography, HPLC MS/MS. Must have a minimum of two (2) to three (3) years’ experience with Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant. Must have a minimum of two (2) to three (3) years performing Animal Necropsies, animal gavage and animal blood collections. Must have a minimum of two (2) to three (3) years performing Equipment Inventory Management. Must have a minimum of two (2) to three (3) years performing Laboratory Management within BSL-2 and BSL-3 environments, to include safety functions and chemical inventory. REQUIRED CITIZENSHIP AND CLEARANCE: U.S. Citizen BPRP and CS-PRP enrollment required. Must pass NACI background check. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees enjoy a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 11 paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. We are proud to state that we do not illegally discriminate in employment decisions on the basis of any protected categories. If you are a person with a disability and you need an accommodation during the application process, please request accommodation. We E-Verify all employees EOE, including Disability/Vets
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