Biohub
Research Associate, Multiomics and Immune Profiling Lab
Biohub, New York, New York, us, 10261
Research Associate, Multiomics and Immune Profiling Lab
Biohub is a 501(c)(3) medical research organization supported by the Chan Zuckerberg Initiative. The Biohub in New York collaborates with Columbia University, Rockefeller University, and Yale University to develop new diagnostics and therapies. Ethical research, innovative science, and inclusiveness guide our work.
The Opportunity Biohub is seeking a skilled Research Associate to support the Multiomics and Immune Profiling Lab (MIP Lab) at Yale University (Biohub Yale Annex). Responsibilities include managing human samples, processing PBMCs, and focusing on immunology, flow cytometry, and cell‑based assays.
What You’ll Do
Maintain and operate cell sorter and spectral flow cytometers.
Manage human samples; coordinate sample processing and experimental workflows with collaborating investigators.
Design and execute complex spectral flow cytometry experiments, including multi‑parameter panel optimization and data acquisitionli>
Set up and optimize in‑vitro cell stimulation assays and functional immunological readouts.
Establish maintain primary cell culture systems and immortalized cell lines for immunological studies.
Develop and implement standardized protocols for cell‑based assays, including viability assessment, proliferation assays, and cytokine measurements.
Perform PBMC isolation and processing.
Perform quality control analysis of flow cytometry and immunological assay data to support experimental troubleshooting.
Maintain detailed documentation of protocols, experimental conditions, and results.
Work closely with other team members to support large‑scale profiling and human immune monitoring projects.
Contribute to the training and mentoring of junior team members on cell and flow cytometry techniques.
Interact with collaborators/PIs and their lab members to discuss and evaluate results.
Interact with external contacts such as staff at biotechnology and reagent companies to consult on and further develop research methods.
Interact with EHS (environment, health, safety) officers to ensure the smooth and safe operation of the laboratory.
What You’ll Bring
Bachelor’s or Master’s degree in immunology, cell biology, molecular biology, or a related field.
Background in immunology with hands‑on experience in immunological assays (e.g., ELISA, cytokine measurements, immune cell functional assays).
1 year of experience with mammalian cell culture, including primary immune cells (e.g., T cells, B cells, monocytes, dendritic cells).
Flow cytometry and cell sorting skills, including panel design, instrument operation, compensation, and data analysis (including using FlowJo).
Experience with in‑vitro cell stimulation assays and functional readouts.
Strong organizational skills and attention to detail in executing multi‑step experimental workflows.
Excellent communication skills and demonstrated ability to work collaboratively in team‑based research environments.
Enthusiasm for technology implementation and large‑scale project execution and coordination rather than independent hypothesis‑driven research.
Nice to Have
3+ years of relevant research experience, or a PhD in a relevant field with a keen interest in performing hands‑on work in team settings.
Experience with high‑throughput or automated cell culture systems.
Familiarity with additional flow cytometry techniques (e.g., imaging flow cytometry).
Knowledge of cell‑based screening platforms and plate‑based assay formats.
Experience working in a core facility or technology platform setting.
Basic programming skills (Python and/or R) for data processing and visualization.
Compensation Base pay range in New York City: $71,000 – $98,000. New hires are typically placed near the lower end and can grow within this range based on job‑related skills and experience.
Benefits for The Whole You
Generous employer match on employee 401(k) contributions.
Paid time off to volunteer at an organization of your choice.
Funding for select family‑forming benefits.
Relocation support for employees who need assistance moving.
We encourage applicants whose previous experience may not perfectly align with each qualification; you may still be an ideal fit for this or another role.
#J-18808-Ljbffr
The Opportunity Biohub is seeking a skilled Research Associate to support the Multiomics and Immune Profiling Lab (MIP Lab) at Yale University (Biohub Yale Annex). Responsibilities include managing human samples, processing PBMCs, and focusing on immunology, flow cytometry, and cell‑based assays.
What You’ll Do
Maintain and operate cell sorter and spectral flow cytometers.
Manage human samples; coordinate sample processing and experimental workflows with collaborating investigators.
Design and execute complex spectral flow cytometry experiments, including multi‑parameter panel optimization and data acquisitionli>
Set up and optimize in‑vitro cell stimulation assays and functional immunological readouts.
Establish maintain primary cell culture systems and immortalized cell lines for immunological studies.
Develop and implement standardized protocols for cell‑based assays, including viability assessment, proliferation assays, and cytokine measurements.
Perform PBMC isolation and processing.
Perform quality control analysis of flow cytometry and immunological assay data to support experimental troubleshooting.
Maintain detailed documentation of protocols, experimental conditions, and results.
Work closely with other team members to support large‑scale profiling and human immune monitoring projects.
Contribute to the training and mentoring of junior team members on cell and flow cytometry techniques.
Interact with collaborators/PIs and their lab members to discuss and evaluate results.
Interact with external contacts such as staff at biotechnology and reagent companies to consult on and further develop research methods.
Interact with EHS (environment, health, safety) officers to ensure the smooth and safe operation of the laboratory.
What You’ll Bring
Bachelor’s or Master’s degree in immunology, cell biology, molecular biology, or a related field.
Background in immunology with hands‑on experience in immunological assays (e.g., ELISA, cytokine measurements, immune cell functional assays).
1 year of experience with mammalian cell culture, including primary immune cells (e.g., T cells, B cells, monocytes, dendritic cells).
Flow cytometry and cell sorting skills, including panel design, instrument operation, compensation, and data analysis (including using FlowJo).
Experience with in‑vitro cell stimulation assays and functional readouts.
Strong organizational skills and attention to detail in executing multi‑step experimental workflows.
Excellent communication skills and demonstrated ability to work collaboratively in team‑based research environments.
Enthusiasm for technology implementation and large‑scale project execution and coordination rather than independent hypothesis‑driven research.
Nice to Have
3+ years of relevant research experience, or a PhD in a relevant field with a keen interest in performing hands‑on work in team settings.
Experience with high‑throughput or automated cell culture systems.
Familiarity with additional flow cytometry techniques (e.g., imaging flow cytometry).
Knowledge of cell‑based screening platforms and plate‑based assay formats.
Experience working in a core facility or technology platform setting.
Basic programming skills (Python and/or R) for data processing and visualization.
Compensation Base pay range in New York City: $71,000 – $98,000. New hires are typically placed near the lower end and can grow within this range based on job‑related skills and experience.
Benefits for The Whole You
Generous employer match on employee 401(k) contributions.
Paid time off to volunteer at an organization of your choice.
Funding for select family‑forming benefits.
Relocation support for employees who need assistance moving.
We encourage applicants whose previous experience may not perfectly align with each qualification; you may still be an ideal fit for this or another role.
#J-18808-Ljbffr