Mass General Brigham
Post Doctoral Fellow Lung Fibrosis
Mass General Brigham – Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital and Harvard Medical School. The Knipe Lab studies mechanisms of endothelial dysfunction in fibrotic lung diseases such as scleroderma-associated ILD and idiopathic pulmonary fibrosis (IPF). NIH funded starting 2025 for two years.
Job Summary Postdoctoral position to investigate mechanisms of vascular biology, lung injury, and lung fibrosis. Project involves animal modeling of lung disease (mice) and in vitro cell culture work with human microvascular endothelial cells.
Responsibilities
Design, execute, analyze, and document in vitro and in vivo studies to define the role of endothelial dysfunction and vascular permeability in the development of fibrosis.
Apply scientific expertise and judgment to develop experimental design and data collection, analysis, and documentation.
Work independently and as part of a highly collaborative team.
Qualifications Core Requirements
Ability to apply scientific expertise and judgment to design, execute, analyze and document in vitro and in vivo studies to define the role of endothelial dysfunction and vascular permeability in the development of fibrosis.
Hands‑on expertise in molecular biology and in vivo disease models.
Track record of significant contributions to research projects and scientific publications.
Ability to work independently as well as part of a highly collaborative team.
Education / Experience
Ph.D. in Molecular Biology, Cellular Biology, or a related discipline with 0‑1 year of relevant post‑graduate experience.
Skills, Abilities, Competencies Required
Mouse handling, husbandry and disease modeling including dissection and tissue harvesting is required. Experience with multiple routes of drug delivery is a plus.
Aseptic technique and in vitro culture of mammalian cells is required. Experience with primary cell isolation is a plus. Experience with 3D cultures is also desired but not required.
Proficiency with molecular biology techniques including western blotting and qRT‑PCR is expected.
Exposure to basics of histology and microscopy including widefield and confocal imaging is a plus.
Exposure to flow cytometry and cell sorting is a plus.
Exposure to large data set analysis and/or bioinformatics is a plus.
Applicants with prior post‑doctoral experience are encouraged to apply. All interested candidates are encouraged to submit their CV/resume accompanied by a cover letter describing prior research experience to Dr. Knipe (rknipe@mgh.harvard.edu).
Location 55 Fruit Street, Cambridge, MA
Remote Type Onsite
EEO Statement The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)‑282‑7642.
Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People‑Focused, half Performance‑Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
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Job Summary Postdoctoral position to investigate mechanisms of vascular biology, lung injury, and lung fibrosis. Project involves animal modeling of lung disease (mice) and in vitro cell culture work with human microvascular endothelial cells.
Responsibilities
Design, execute, analyze, and document in vitro and in vivo studies to define the role of endothelial dysfunction and vascular permeability in the development of fibrosis.
Apply scientific expertise and judgment to develop experimental design and data collection, analysis, and documentation.
Work independently and as part of a highly collaborative team.
Qualifications Core Requirements
Ability to apply scientific expertise and judgment to design, execute, analyze and document in vitro and in vivo studies to define the role of endothelial dysfunction and vascular permeability in the development of fibrosis.
Hands‑on expertise in molecular biology and in vivo disease models.
Track record of significant contributions to research projects and scientific publications.
Ability to work independently as well as part of a highly collaborative team.
Education / Experience
Ph.D. in Molecular Biology, Cellular Biology, or a related discipline with 0‑1 year of relevant post‑graduate experience.
Skills, Abilities, Competencies Required
Mouse handling, husbandry and disease modeling including dissection and tissue harvesting is required. Experience with multiple routes of drug delivery is a plus.
Aseptic technique and in vitro culture of mammalian cells is required. Experience with primary cell isolation is a plus. Experience with 3D cultures is also desired but not required.
Proficiency with molecular biology techniques including western blotting and qRT‑PCR is expected.
Exposure to basics of histology and microscopy including widefield and confocal imaging is a plus.
Exposure to flow cytometry and cell sorting is a plus.
Exposure to large data set analysis and/or bioinformatics is a plus.
Applicants with prior post‑doctoral experience are encouraged to apply. All interested candidates are encouraged to submit their CV/resume accompanied by a cover letter describing prior research experience to Dr. Knipe (rknipe@mgh.harvard.edu).
Location 55 Fruit Street, Cambridge, MA
Remote Type Onsite
EEO Statement The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)‑282‑7642.
Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People‑Focused, half Performance‑Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
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