Glyphic
Senior/Staff Scientist, Biopolymer Chemistry Berkeley, CA
Glyphic, Jackson, Mississippi, United States
Senior/Staff Scientist, Biopolymer Chemistry
About Glyphic:
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you: Glyphic is seeking a highly motivated and experienced Scientist to join the Chemistry Department to assist in the advancement of our cutting-edge single molecule proteome sequencing platform. The ideal candidate will have a strong background in nucleic acid & protein chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross-disciplinary team of scientists, engineers, and bio-informaticians to rapidly deliver consistent results and insights that accelerate the development cycle. Responsibilities: Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility Synthesize assay specific reagents and materials for the proteome sequencing platform Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development PhD in chemistry, organic chemistry, or related field with 5+ years of relevant post-graduate experience, preferably in an industrial or startup setting Comprehensive knowledge in bioconjugation and biorthogonal conjugation methods and techniques Experience with peptide synthesis, characterization, and purification Experience with nucleic acid synthesis, natural and modified analogs Knowledgeable about protein purification and fractionation from complex sample matrices Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports Experience inthe development of commercial products, a plus Excellent problem-solving skills and attention to detail Strong written and verbal communication skills, with the ability to document experiments clearly and collaborate effectively with multidisciplinary teams Experience in data analysis software Experience instatistical and DOE software Adapts to fast-paced environments with changing priorities and responsibilities Compensation Estimated Base Salary $120K – $183K This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas. Benefits and Perks:
Employee Stock Option Plan Employer Retirement Contributions to 401(k) Generous Paid Time Off Paid Maternity and Paternity Leave Office Snacks and Beverages Regular Team Bonding Activities We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. Apply for this job
* indicates a required field First Name * Last Name * Preferred First Name Email * Phone Country * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website How did you hear about this job? Are you legally authorized to work for Glyphic Biotechnologies in the United States? * Select... Will you require sponsorship for employment visa status now or in the future? * Select... If offered a position with Glyphic Biotechnologies, I understand my employment may be contingent upon a reference check, and any other required check or screening specified in the job description, the offer letter and/or discussed during the interview process. * Select... How many combined years of industry experience do you have in a relevant chemistry role? * Select... Do you have at least 1 year of hands-on experience in peptide synthesis and purification? * Select... Do you have at least 1 year of hands-on experience in bioconjugation and biorthogonal conjugation? * Select... Do you have at least 1 year of hands-on experience in site specific amino acid chemistry? * Select...
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About Glyphic:
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you: Glyphic is seeking a highly motivated and experienced Scientist to join the Chemistry Department to assist in the advancement of our cutting-edge single molecule proteome sequencing platform. The ideal candidate will have a strong background in nucleic acid & protein chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross-disciplinary team of scientists, engineers, and bio-informaticians to rapidly deliver consistent results and insights that accelerate the development cycle. Responsibilities: Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility Synthesize assay specific reagents and materials for the proteome sequencing platform Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development PhD in chemistry, organic chemistry, or related field with 5+ years of relevant post-graduate experience, preferably in an industrial or startup setting Comprehensive knowledge in bioconjugation and biorthogonal conjugation methods and techniques Experience with peptide synthesis, characterization, and purification Experience with nucleic acid synthesis, natural and modified analogs Knowledgeable about protein purification and fractionation from complex sample matrices Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports Experience inthe development of commercial products, a plus Excellent problem-solving skills and attention to detail Strong written and verbal communication skills, with the ability to document experiments clearly and collaborate effectively with multidisciplinary teams Experience in data analysis software Experience instatistical and DOE software Adapts to fast-paced environments with changing priorities and responsibilities Compensation Estimated Base Salary $120K – $183K This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas. Benefits and Perks:
Employee Stock Option Plan Employer Retirement Contributions to 401(k) Generous Paid Time Off Paid Maternity and Paternity Leave Office Snacks and Beverages Regular Team Bonding Activities We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. Apply for this job
* indicates a required field First Name * Last Name * Preferred First Name Email * Phone Country * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website How did you hear about this job? Are you legally authorized to work for Glyphic Biotechnologies in the United States? * Select... Will you require sponsorship for employment visa status now or in the future? * Select... If offered a position with Glyphic Biotechnologies, I understand my employment may be contingent upon a reference check, and any other required check or screening specified in the job description, the offer letter and/or discussed during the interview process. * Select... How many combined years of industry experience do you have in a relevant chemistry role? * Select... Do you have at least 1 year of hands-on experience in peptide synthesis and purification? * Select... Do you have at least 1 year of hands-on experience in bioconjugation and biorthogonal conjugation? * Select... Do you have at least 1 year of hands-on experience in site specific amino acid chemistry? * Select...
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