Madrigal Pharmaceuticals
Senior Director, Agentic AI and Automation
Madrigal Pharmaceuticals, Conshohocken, Pennsylvania, United States
Overview
Senior Director, Agentic AI and Automation
at Madrigal Pharmaceuticals. Join to apply for this role. Madrigal is a biopharmaceutical company pursuing novel therapeutics. Our first therapy, Rezdiffra (resmetirom), has FDA accelerated approval for adults with NASH with moderate to advanced liver fibrosis and is in a Phase 3 trial for NASH with compensated cirrhosis. Job Title
Senior Director, Agentic AI & Automation Department
IT Manager
Executive Director, AI and Data Science Job Profile Summary
Madrigal is seeking an innovative, systems-thinking leader to set the vision, design, and enterprise-wide deployment of agentic workflows—AI-enabled, plan–act–reflect automations that learn over time and augment human decision‑making. You will orchestrate autonomous or semi-autonomous digital agents across R&D, Commercial, Medical Affairs, and Corporate functions, accelerating operational efficiency and unlocking the full potential of generative and agentic AI within a regulated biotech environment. Responsibilities
Define and execute a multi-year agentic AI & RPA roadmap converging hyperautomation, process-mining, and LLM-driven workflows. Operationalize an Agentic Automation Center of Excellence (CoE) governing standards, reusable assets, and ROI tracking. Partner with cross-functional executives to prioritise high-value automations across the business. Role & Responsibilities (continued)
Architect modular multi-agent systems powered by frontier LLMs and agent frameworks; design secure agent-to-agent communication with shared memory and credential vaults; implement enterprise MCP engine and Agent Protocol standards enabling human–agent–bot collaboration. Standardise integration with vector stores and cloud MLOps platforms (Azure AI Search, Databricks, SageMaker, Vertex AI). Build event-driven, low-code pipelines to trigger agentic RPA tasks in real time; implement observability and governance; establish GxP-compliant validation for autonomous workflows. Leverage process- and task-mining insights to auto-generate automation backlogs and measure value. Qualifications
Advanced degree (Ph.D. preferred) in AI, Data Science, Computer Science, Applied Mathematics, Engineering, Physics, or related field. 15+ years leading AI/ML or intelligent-automation initiatives; 10+ years hands-on with Python, SQL, R, MATLAB, PyTorch, Keras, Git. 12+ years architecting ML/deep-learning solutions including LLMs (GPT-4, BERT, LLaMA, Dolly) and RAG pipelines. 8+ years building web apps and advanced data products; 8+ years implementing scalable AI/ML on platforms like Databricks or Dataiku with strong AI/MLOps. Deep knowledge of cloud data platforms (AWS, Azure, GCP) and compliance (GxP, HIPAA, GDPR). Strong theoretical foundation in ML/AI with contributions to papers and presentations. Exceptional written & verbal communication skills translating complex research to executives. Leadership & Autonomy
Leads multi-disciplinary squads and influences enterprise-wide AI & automation strategy; operates with significant autonomy to set technical direction and allocate resources. Problem Solving
Applies deep expertise in ML, generative AI, and systems engineering to solve complex, cross-domain challenges; uses quantitative skills to inform data-driven decisions and optimize agentic workflows. Impact
Accelerates operational efficiency, compliance, and patient outcomes by embedding intelligent automation across critical functions; establishes Madrigal as a leader in safe, regulated agentic AI deployment. Compensation
Base salary determined by qualifications, skills, education, experience, business needs, and market; may include bonus, equity, and comprehensive benefits (flexible PTO, medical, dental, vision, life and disability insurance). Equal Opportunity
Madrigal is an Equal Opportunity Employer. All employment decisions are based on qualifications, merit, and business need, without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristics protected by law. Notes
Please be aware of scams: Madrigal does not conduct interviews via text or in chat rooms, does not charge fees, and will only use authorized Madrigal contact information.
#J-18808-Ljbffr
Senior Director, Agentic AI and Automation
at Madrigal Pharmaceuticals. Join to apply for this role. Madrigal is a biopharmaceutical company pursuing novel therapeutics. Our first therapy, Rezdiffra (resmetirom), has FDA accelerated approval for adults with NASH with moderate to advanced liver fibrosis and is in a Phase 3 trial for NASH with compensated cirrhosis. Job Title
Senior Director, Agentic AI & Automation Department
IT Manager
Executive Director, AI and Data Science Job Profile Summary
Madrigal is seeking an innovative, systems-thinking leader to set the vision, design, and enterprise-wide deployment of agentic workflows—AI-enabled, plan–act–reflect automations that learn over time and augment human decision‑making. You will orchestrate autonomous or semi-autonomous digital agents across R&D, Commercial, Medical Affairs, and Corporate functions, accelerating operational efficiency and unlocking the full potential of generative and agentic AI within a regulated biotech environment. Responsibilities
Define and execute a multi-year agentic AI & RPA roadmap converging hyperautomation, process-mining, and LLM-driven workflows. Operationalize an Agentic Automation Center of Excellence (CoE) governing standards, reusable assets, and ROI tracking. Partner with cross-functional executives to prioritise high-value automations across the business. Role & Responsibilities (continued)
Architect modular multi-agent systems powered by frontier LLMs and agent frameworks; design secure agent-to-agent communication with shared memory and credential vaults; implement enterprise MCP engine and Agent Protocol standards enabling human–agent–bot collaboration. Standardise integration with vector stores and cloud MLOps platforms (Azure AI Search, Databricks, SageMaker, Vertex AI). Build event-driven, low-code pipelines to trigger agentic RPA tasks in real time; implement observability and governance; establish GxP-compliant validation for autonomous workflows. Leverage process- and task-mining insights to auto-generate automation backlogs and measure value. Qualifications
Advanced degree (Ph.D. preferred) in AI, Data Science, Computer Science, Applied Mathematics, Engineering, Physics, or related field. 15+ years leading AI/ML or intelligent-automation initiatives; 10+ years hands-on with Python, SQL, R, MATLAB, PyTorch, Keras, Git. 12+ years architecting ML/deep-learning solutions including LLMs (GPT-4, BERT, LLaMA, Dolly) and RAG pipelines. 8+ years building web apps and advanced data products; 8+ years implementing scalable AI/ML on platforms like Databricks or Dataiku with strong AI/MLOps. Deep knowledge of cloud data platforms (AWS, Azure, GCP) and compliance (GxP, HIPAA, GDPR). Strong theoretical foundation in ML/AI with contributions to papers and presentations. Exceptional written & verbal communication skills translating complex research to executives. Leadership & Autonomy
Leads multi-disciplinary squads and influences enterprise-wide AI & automation strategy; operates with significant autonomy to set technical direction and allocate resources. Problem Solving
Applies deep expertise in ML, generative AI, and systems engineering to solve complex, cross-domain challenges; uses quantitative skills to inform data-driven decisions and optimize agentic workflows. Impact
Accelerates operational efficiency, compliance, and patient outcomes by embedding intelligent automation across critical functions; establishes Madrigal as a leader in safe, regulated agentic AI deployment. Compensation
Base salary determined by qualifications, skills, education, experience, business needs, and market; may include bonus, equity, and comprehensive benefits (flexible PTO, medical, dental, vision, life and disability insurance). Equal Opportunity
Madrigal is an Equal Opportunity Employer. All employment decisions are based on qualifications, merit, and business need, without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristics protected by law. Notes
Please be aware of scams: Madrigal does not conduct interviews via text or in chat rooms, does not charge fees, and will only use authorized Madrigal contact information.
#J-18808-Ljbffr