Merck
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
Merck, West Point, Nebraska, United States, 68788
Job Description
The (remote) position is only applicable for those that are not within commutable distance to primary sites noted in posting. Please note that standard commute is (less than).
The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will be a key contributor to multi-disciplinary drug development and discovery efforts providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.
Responsibilities
Work within teams of highly collaborative, cross‑functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities.
Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile.
Assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy.
Author source reports and documents in support of regulatory filings.
Independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making.
Qualifications
Education:
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields.
Experience:
Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience, including small molecules, antibodies, and drug conjugates; experience integrating preclinical DMPK and pharmacology for translational modeling and simulation; experience assessing PK/PD impact and communicating recommendations; experience authoring documents for IB, IND, WMA filings.
Demonstrated track record as an effective collaborator on multi‑disciplinary discovery and development teams; strong leadership, interpersonal, communication, problem‑solving, and collaboration skills.
Preferred: strong publication track record; experience representing DMPK function in evaluating third‑party assets; experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP); mentoring or supervising junior staff.
Location & Travel Remote work is available for U.S. residents. Travel may require up to 10% within the U.S.
U.S. Hybrid Work Model : Effective September 5, 2023, employees in office‑based positions will work a hybrid model of three on‑site days per week, Monday‑Thursday, with Friday remote. This does not apply to positions designated as “remote”.
Salary $169,700.00 – $267,200.00
Benefits We offer a comprehensive benefits package, including medical, dental, vision, retirement (401(k)), paid holidays, and vacation. Detailed information is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Equal Employment Opportunity Merck is an Equal Employment Opportunity Employer. We provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC resources.
Additional Information We are proud to foster diversity and inclusion in our workforce. We encourage candidates to respectfully challenge each other’s thinking and approach problems collaboratively.
Applicants with arrest and conviction records for San Francisco are considered in compliance with the San Francisco Fair Chance Ordinance. Applicants with criminal histories for Los Angeles are considered in compliance with the Los Angeles Fair Chance Initiative.
Search firm representatives: Merck & Co. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms without a valid written search agreement are deemed the sole property of the company. No fee will be paid if no pre-existing agreement is in place.
Employee status: Regular
Domestic relocation: Domestic
Visa sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Remote
Job Posting End Date: 10/23/2025
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The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will be a key contributor to multi-disciplinary drug development and discovery efforts providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.
Responsibilities
Work within teams of highly collaborative, cross‑functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities.
Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile.
Assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy.
Author source reports and documents in support of regulatory filings.
Independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making.
Qualifications
Education:
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields.
Experience:
Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience, including small molecules, antibodies, and drug conjugates; experience integrating preclinical DMPK and pharmacology for translational modeling and simulation; experience assessing PK/PD impact and communicating recommendations; experience authoring documents for IB, IND, WMA filings.
Demonstrated track record as an effective collaborator on multi‑disciplinary discovery and development teams; strong leadership, interpersonal, communication, problem‑solving, and collaboration skills.
Preferred: strong publication track record; experience representing DMPK function in evaluating third‑party assets; experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP); mentoring or supervising junior staff.
Location & Travel Remote work is available for U.S. residents. Travel may require up to 10% within the U.S.
U.S. Hybrid Work Model : Effective September 5, 2023, employees in office‑based positions will work a hybrid model of three on‑site days per week, Monday‑Thursday, with Friday remote. This does not apply to positions designated as “remote”.
Salary $169,700.00 – $267,200.00
Benefits We offer a comprehensive benefits package, including medical, dental, vision, retirement (401(k)), paid holidays, and vacation. Detailed information is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Equal Employment Opportunity Merck is an Equal Employment Opportunity Employer. We provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC resources.
Additional Information We are proud to foster diversity and inclusion in our workforce. We encourage candidates to respectfully challenge each other’s thinking and approach problems collaboratively.
Applicants with arrest and conviction records for San Francisco are considered in compliance with the San Francisco Fair Chance Ordinance. Applicants with criminal histories for Los Angeles are considered in compliance with the Los Angeles Fair Chance Initiative.
Search firm representatives: Merck & Co. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms without a valid written search agreement are deemed the sole property of the company. No fee will be paid if no pre-existing agreement is in place.
Employee status: Regular
Domestic relocation: Domestic
Visa sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Remote
Job Posting End Date: 10/23/2025
#J-18808-Ljbffr