Merck
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
Merck, Madison, Wisconsin, us, 53774
Overview
The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. The standard commute is less than 50 miles. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will be a key contributor to multidisciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics. The key responsibilities will be to work within teams of highly collaborative, cross-functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities. The Principal Scientist will guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile. They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy. They will author source reports and documents in support of regulatory filings. They will independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making. The ideal candidate must be able to work collaboratively in a fast-paced environment, drive scientific development and innovation, and have excellent interpersonal and communication skills. Experience supporting both small molecule and biologics programs is desired. Responsibilities
Work within teams of cross-functional scientists to contribute to discovery and clinical development of therapeutics across various modalities. Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support discovery of therapeutics with the desired DMPK profile. Assess DDI risk using static mechanistic and/or PBPK models and guide clinical development teams on DDI strategy. Author source reports and documents in support of regulatory filings. Independently evaluate and predict potential program risks, while implementing strategies to address liabilities to ensure efficient program progression and decision making. Qualifications
Education Minimum Requirement: PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields. Required Experience and Skills: Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience in a relevant field with a focus on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates). Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies. Experience assessing the impact of various factors on pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management. Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries. Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams. Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines. Preferred Experience and Skills:
Strong publication track record Experience representing the DMPK function in the evaluation of third-party assets. Experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP). Experience mentoring or supervising junior staff. EEO and Diversity
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. We are committed to inclusion and encourage our colleagues to respectfully challenge one another’s thinking and problem solve collectively. Learn more about your rights under U.S. Equal Opportunity Employment laws. Additional Details
U.S. Hybrid Work Model:
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a hybrid model with three on-site days per week and remote Fridays, unless business critical tasks require on-site presence. This model does not apply to certain roles designated as remote. Salary:
The salary range for this role is $169,700.00 – $267,200.00. Compensation is based on factors including education, qualifications, experience, skills, location, and business needs. Benefits:
We offer a comprehensive package of benefits including medical, dental, vision, retirement plans (401(k)), paid holidays, vacation, and sick days. How to Apply:
You can apply for this role through the official posting page. The application deadline is stated in the posting.
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The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. The standard commute is less than 50 miles. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will be a key contributor to multidisciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics. The key responsibilities will be to work within teams of highly collaborative, cross-functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities. The Principal Scientist will guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile. They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy. They will author source reports and documents in support of regulatory filings. They will independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making. The ideal candidate must be able to work collaboratively in a fast-paced environment, drive scientific development and innovation, and have excellent interpersonal and communication skills. Experience supporting both small molecule and biologics programs is desired. Responsibilities
Work within teams of cross-functional scientists to contribute to discovery and clinical development of therapeutics across various modalities. Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support discovery of therapeutics with the desired DMPK profile. Assess DDI risk using static mechanistic and/or PBPK models and guide clinical development teams on DDI strategy. Author source reports and documents in support of regulatory filings. Independently evaluate and predict potential program risks, while implementing strategies to address liabilities to ensure efficient program progression and decision making. Qualifications
Education Minimum Requirement: PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields. Required Experience and Skills: Master’s degree with 10+ years relevant experience or PhD with 7+ years of industry/applied drug discovery/development experience in a relevant field with a focus on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates). Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies. Experience assessing the impact of various factors on pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management. Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries. Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams. Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines. Preferred Experience and Skills:
Strong publication track record Experience representing the DMPK function in the evaluation of third-party assets. Experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP). Experience mentoring or supervising junior staff. EEO and Diversity
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. We are committed to inclusion and encourage our colleagues to respectfully challenge one another’s thinking and problem solve collectively. Learn more about your rights under U.S. Equal Opportunity Employment laws. Additional Details
U.S. Hybrid Work Model:
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a hybrid model with three on-site days per week and remote Fridays, unless business critical tasks require on-site presence. This model does not apply to certain roles designated as remote. Salary:
The salary range for this role is $169,700.00 – $267,200.00. Compensation is based on factors including education, qualifications, experience, skills, location, and business needs. Benefits:
We offer a comprehensive package of benefits including medical, dental, vision, retirement plans (401(k)), paid holidays, vacation, and sick days. How to Apply:
You can apply for this role through the official posting page. The application deadline is stated in the posting.
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