SystImmune
Overview
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Scientist/Senior Scientist, Upstream
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SystImmune . SystImmune is a leading clinical-stage biopharmaceutical company with locations in Redmond, WA and Princeton, NJ. It focuses on developing innovative cancer therapies using bi-specific, multi-specific antibodies and antibody-drug conjugates (ADCs). The company has assets in various clinical trial stages and a robust preclinical pipeline. Responsibilities
Lead and execute upstream project process development (USP) and technology transfer to support clinical manufacturing processes for the protein therapeutics pipeline. Apply technical knowledge in CHO upstream process development (bioreactor process design, scale-up, media and feed optimization, etc.); draft study protocols, design and execute experiments, perform in-process tests, characterize harvest material for downstream teams, and author technical reports. Stay abreast of technical advancements in CMC CHO cell line development and upstream process development and technology transfer aligned with cGMP clinical manufacturing. Support transfer, development, and scale-up of CHO cell culture processes from research into process development and manufacturing to enable production of clinical material. Collaborate with downstream process development and analytical development teams to advance recombinant protein programs. Lead and support early-stage CMC development activities, including non-GMP/clinical manufacturing support and implementation of process improvements as programs advance. Analyze, interpret, and document complex technical information; apply DoE and multi-variant analysis. Manage project scope and timelines in a fast-paced, rigorous environment. Data analysis, interpretation, and effective communication to management. Qualifications
PhD with 3+ years of upstream bioprocess experience. Significant experience with bioreactor use, optimization, and scale-up; DasGip or DASware experience is desired; perfusion experience a plus. Ability to work independently to troubleshoot processes and develop new methods in a collaborative matrix. Experience in scaling up and technology transfer to manufacturing and understanding of GMP. Knowledge in other areas of therapeutic protein process development (downstream, formulation, analytics) is valued. Excellent communication and interpersonal skills to build positive relationships with stakeholders. Proactive in introducing new methods, mentoring colleagues, and maintaining lab efficiency. Attention to detail and accuracy. Ability to work on multiple projects simultaneously. Compensation and Benefits: The expected base salary range for this position is $90,000 to $140,000 annually. Actual compensation will be based on qualifications, experience, and skills. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) with 50% company match up to 3% and a 5-year vesting schedule, 15 PTO days per year, sick leave, 11 paid holidays, and more. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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Join to apply for the
Scientist/Senior Scientist, Upstream
role at
SystImmune . SystImmune is a leading clinical-stage biopharmaceutical company with locations in Redmond, WA and Princeton, NJ. It focuses on developing innovative cancer therapies using bi-specific, multi-specific antibodies and antibody-drug conjugates (ADCs). The company has assets in various clinical trial stages and a robust preclinical pipeline. Responsibilities
Lead and execute upstream project process development (USP) and technology transfer to support clinical manufacturing processes for the protein therapeutics pipeline. Apply technical knowledge in CHO upstream process development (bioreactor process design, scale-up, media and feed optimization, etc.); draft study protocols, design and execute experiments, perform in-process tests, characterize harvest material for downstream teams, and author technical reports. Stay abreast of technical advancements in CMC CHO cell line development and upstream process development and technology transfer aligned with cGMP clinical manufacturing. Support transfer, development, and scale-up of CHO cell culture processes from research into process development and manufacturing to enable production of clinical material. Collaborate with downstream process development and analytical development teams to advance recombinant protein programs. Lead and support early-stage CMC development activities, including non-GMP/clinical manufacturing support and implementation of process improvements as programs advance. Analyze, interpret, and document complex technical information; apply DoE and multi-variant analysis. Manage project scope and timelines in a fast-paced, rigorous environment. Data analysis, interpretation, and effective communication to management. Qualifications
PhD with 3+ years of upstream bioprocess experience. Significant experience with bioreactor use, optimization, and scale-up; DasGip or DASware experience is desired; perfusion experience a plus. Ability to work independently to troubleshoot processes and develop new methods in a collaborative matrix. Experience in scaling up and technology transfer to manufacturing and understanding of GMP. Knowledge in other areas of therapeutic protein process development (downstream, formulation, analytics) is valued. Excellent communication and interpersonal skills to build positive relationships with stakeholders. Proactive in introducing new methods, mentoring colleagues, and maintaining lab efficiency. Attention to detail and accuracy. Ability to work on multiple projects simultaneously. Compensation and Benefits: The expected base salary range for this position is $90,000 to $140,000 annually. Actual compensation will be based on qualifications, experience, and skills. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) with 50% company match up to 3% and a 5-year vesting schedule, 15 PTO days per year, sick leave, 11 paid holidays, and more. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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