Lyterian Therapeutics
Associate Director, Computational Chemistry
Lyterian Therapeutics, South San Francisco, California, us, 94083
At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co‑opting physiologically‑relevant protein homeostatic mechanisms to regulate genetically‑validated targets.
As an Associate Director, Computational Chemistry, you will apply computational chemistry methods to support drug discovery, optimization, and development within the chemistry team. You will collaborate with medicinal chemists and biologists to guide the optimization of drug candidates that induce protein degradation.
We look for teammates who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek candidates who are self‑motivated, collaborative, proactive, and possess a strong desire to discover novel biology and new drugs. Efficient time management, excellent organizational and communication skills, and passion for high‑quality, translational science are essential.
Impact You'll Make
Lead Lyterian’s CADD‑related research such as virtual screening, hit identification and structure‑based design during lead optimization of small molecules
Work with medicinal chemists and biologists to guide the optimization of drug candidates
Use machine‑learning (ML) to build in silico models to predict DMPK properties
Perform and automate high‑throughput molecular dynamics simulations to predict protein function and protein‑ligand binding
Scientific programming to enhance our scientific methods and capabilities
Apply established tools but also design new methods/tools to answer specific questions
Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications
Stay up‑to‑date with emerging scientific literature
Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals
Qualifications
PhD in computational chemistry or related discipline with 7–15 years of industrial/postdoctoral experience in drug discovery
Expertise in computer‑aided drug design (CADD)/structure‑ and ligand‑based design
Practical, working experience with computational chemistry software from companies such as Dotmatics, Schrodinger, Molecular Operating Environment (MOE), OpenEye, and Gaussian
Experience in collaborating with other functional team members such as chemists and biologists
Experience in QSAR, QSPR, conformational analysis and as much as the following areas: molecular mechanics and dynamics, quantum mechanics, statistical design of experiments (DoE), multiparameter optimization, and/or Artificial Intelligence/Machine Learning (AI/ML)
Computer skills including programming experience with languages such as perl, python, or C++, preferably in a UNIX environment is a plus
Expertise in algorithms for cheminformatics/database applications, with understanding of software development strategy and practice is a plus
A solid understanding of experimental assay methods and technology used to identify and quantify protein‑ligand interactions, a working knowledge of in vitro/in vivo DMPK principles is a plus
Initiative and boldness to dive into a fast‑paced new startup
At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
The expected base salary range for the Associate Director level is $195,000 – $211,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.
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As an Associate Director, Computational Chemistry, you will apply computational chemistry methods to support drug discovery, optimization, and development within the chemistry team. You will collaborate with medicinal chemists and biologists to guide the optimization of drug candidates that induce protein degradation.
We look for teammates who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek candidates who are self‑motivated, collaborative, proactive, and possess a strong desire to discover novel biology and new drugs. Efficient time management, excellent organizational and communication skills, and passion for high‑quality, translational science are essential.
Impact You'll Make
Lead Lyterian’s CADD‑related research such as virtual screening, hit identification and structure‑based design during lead optimization of small molecules
Work with medicinal chemists and biologists to guide the optimization of drug candidates
Use machine‑learning (ML) to build in silico models to predict DMPK properties
Perform and automate high‑throughput molecular dynamics simulations to predict protein function and protein‑ligand binding
Scientific programming to enhance our scientific methods and capabilities
Apply established tools but also design new methods/tools to answer specific questions
Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications
Stay up‑to‑date with emerging scientific literature
Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals
Qualifications
PhD in computational chemistry or related discipline with 7–15 years of industrial/postdoctoral experience in drug discovery
Expertise in computer‑aided drug design (CADD)/structure‑ and ligand‑based design
Practical, working experience with computational chemistry software from companies such as Dotmatics, Schrodinger, Molecular Operating Environment (MOE), OpenEye, and Gaussian
Experience in collaborating with other functional team members such as chemists and biologists
Experience in QSAR, QSPR, conformational analysis and as much as the following areas: molecular mechanics and dynamics, quantum mechanics, statistical design of experiments (DoE), multiparameter optimization, and/or Artificial Intelligence/Machine Learning (AI/ML)
Computer skills including programming experience with languages such as perl, python, or C++, preferably in a UNIX environment is a plus
Expertise in algorithms for cheminformatics/database applications, with understanding of software development strategy and practice is a plus
A solid understanding of experimental assay methods and technology used to identify and quantify protein‑ligand interactions, a working knowledge of in vitro/in vivo DMPK principles is a plus
Initiative and boldness to dive into a fast‑paced new startup
At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
The expected base salary range for the Associate Director level is $195,000 – $211,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.
#J-18808-Ljbffr