Mount Sinai Health System
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Post Doctoral Fellow-MSH-12903-003
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Mount Sinai Health System .
Description Details of Research Project:
To decipher site‑specific macrophage subtypes in the healthy human intestine. We aim to generate a comprehensive map of macrophage populations, focusing on regional differences between the left and right colon and the ileum. Using a multimodal, high‑dimensional approach – including scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology – we will analyze intestinal biopsies to characterize macrophage phenotypes, spatial localization, and transcriptional profiles.
To decipher IBD‑specific macrophage subtypes across inflamed and uninflamed intestinal regions. Building upon the healthy tissue atlas, we will apply the same multimodal, high‑dimensional approach – encompassing scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology – to characterize site‑specific macrophage populations in patients with Ulcerative colitis and Crohn’s disease.
To evaluate macrophage profiles as predictive biomarkers of therapeutic response in IBD. We hypothesize that distinct, site‑specific macrophage signatures are predictive of response to targeted therapy. To test this, we will establish a longitudinal patient cohort undergoing anti‑IL‑23 therapy, with intestinal biopsies collected prior to treatment initiation and during therapy.
Responsibilities With our multimodal approach, we want to generate a high‑resolution atlas of macrophage heterogeneity across distinct intestinal regions, establishing a critical baseline for comparison in disease states.
By applying our analyses to patients with inflammatory bowel disease (IBD) will uncover alterations in the macrophage compartment across different intestinal sites during active and quiescent inflammation, providing critical insights into the role of macrophages in the pathogenesis of IBD.
In a group of patients with Crohn’s disease undergoing anti‑IL‑23 therapy we will characterize the macrophage compartment over time. Integration of these data with clinical and endoscopic outcomes through advanced bioinformatic analyses will assess the potential of macrophage profiles as predictive biomarkers of therapeutic response in IBD.
Qualifications
Technical Duties: scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology performed on patient samples (intestinal biopsies).
Educational and other Requirements for the position: doctoral degree (MD), research experience, communication skills.
Experience Required: research experience including scientific publications.
Employer Description The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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Post Doctoral Fellow-MSH-12903-003
role at
Mount Sinai Health System .
Description Details of Research Project:
To decipher site‑specific macrophage subtypes in the healthy human intestine. We aim to generate a comprehensive map of macrophage populations, focusing on regional differences between the left and right colon and the ileum. Using a multimodal, high‑dimensional approach – including scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology – we will analyze intestinal biopsies to characterize macrophage phenotypes, spatial localization, and transcriptional profiles.
To decipher IBD‑specific macrophage subtypes across inflamed and uninflamed intestinal regions. Building upon the healthy tissue atlas, we will apply the same multimodal, high‑dimensional approach – encompassing scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology – to characterize site‑specific macrophage populations in patients with Ulcerative colitis and Crohn’s disease.
To evaluate macrophage profiles as predictive biomarkers of therapeutic response in IBD. We hypothesize that distinct, site‑specific macrophage signatures are predictive of response to targeted therapy. To test this, we will establish a longitudinal patient cohort undergoing anti‑IL‑23 therapy, with intestinal biopsies collected prior to treatment initiation and during therapy.
Responsibilities With our multimodal approach, we want to generate a high‑resolution atlas of macrophage heterogeneity across distinct intestinal regions, establishing a critical baseline for comparison in disease states.
By applying our analyses to patients with inflammatory bowel disease (IBD) will uncover alterations in the macrophage compartment across different intestinal sites during active and quiescent inflammation, providing critical insights into the role of macrophages in the pathogenesis of IBD.
In a group of patients with Crohn’s disease undergoing anti‑IL‑23 therapy we will characterize the macrophage compartment over time. Integration of these data with clinical and endoscopic outcomes through advanced bioinformatic analyses will assess the potential of macrophage profiles as predictive biomarkers of therapeutic response in IBD.
Qualifications
Technical Duties: scRNA‑seq, flow cytometry, spatial transcriptomics, and multiplexed histology performed on patient samples (intestinal biopsies).
Educational and other Requirements for the position: doctoral degree (MD), research experience, communication skills.
Experience Required: research experience including scientific publications.
Employer Description The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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