SVP, Clinical Pharmacology & Translational (Thousand Oaks)

SVP, Clinical Pharmacology & Translational

Join to apply for the SVP, Clinical Pharmacology & Translational role at Latigo Biotherapeutics, Inc.

SVP, Clinical Pharmacology & Translational

16 hours ago Be among the first 25 applicants

Join to apply for the SVP, Clinical Pharmacology & Translational role at Latigo Biotherapeutics, Inc.

Location: Los Angeles, CA or San Francisco Bay Area, CA
Reports to: Chief Executive Officer
Type: Full-Time, Executive
Company Stage: Clinical / Private
Latigo Biotherapeutics Overview
We are a privately held, clinical-stage biotechnology company focused on developing non-addictive, non-opioid therapies for acute and chronic pain. Latigo has multiple small molecules targeting Nav1.8 in Phase 1 and 2 and anticipate transitioning into pivotal studies in 2025. Were science-driven, well funded, nimble, and committed to developing drugs that matter.
Position Summary
The SVP of Clinical Pharmacology will lead the strategy and execution of all clinical pharmacology activities, including early development, IND-enabling PK/PD characterization, dose selection, exposure-response modeling, and regulatory pharmacology submissions. This role is critical to guiding the development of first-in-human and subsequent clinical studies across our pipeline, with a focus on data-driven, model-informed drug development.
Key Responsibilities

• Design and implement translational strategies across programs to support IND and early clinical development.
• Integrate preclinical and clinical data to inform dose selection, patient stratification, and mechanism insights.
• Define and lead clinical pharmacology strategy across all programs.
• Drive IND-enabling pharmacokinetics and pharmacodynamics planning.
• Lead the design and interpretation of clinical pharmacology studies: SAD/MAD, food effect, DDI, QTc, etc.
• Develop and refine exposure-response models to inform dose and schedule decisions.
• Oversee PK/PD modeling and simulation, including population PK and PBPK modeling.
• Contribute to clinical trial protocols, study reports, and regulatory documents (e.g., INDs, IBs, briefing books).
• Serve as subject matter expert in health authority interactions (FDA, EMA, PMDA).
• Design and oversee GLP and non-GLP studies to support INDs, CTAs, and global regulatory filings.
• Guide the selection of species, dose, duration, and endpoints for in vivo studies.
• Work closely with clinical, regulatory, and CMC teams to align on development strategy.
• Lead and mentor a growing team.
  

• Ph.D., Pharm.D., or M.D. in pharmacology, pharmaceutical sciences, or related field.
• 15+ years of experience in clinical pharmacology and drug development, ideally with biotech exposure.
• Track record of IND filings and progression through Ph1Ph2 development.
• Experienced in small molecule development.
• Effective communicator with experience presenting to internal stakeholders, regulatory agencies, and at conferences.
• Leadership experience in building and scaling teams in a fast-paced environment.

Seniority level

• Seniority level

  Executive

Employment type

• Employment type

  Full-time

Job function

• Job function

  Other

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