Revolution Medicines
Senior Scientist I, DMPK
Revolution Medicines, San Francisco, California, United States, 94199
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Senior Scientist I, DMPK
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Revolution Medicines 3 days ago Be among the first 25 applicants Join to apply for the
Senior Scientist I, DMPK
role at
Revolution Medicines This range is provided by Revolution Medicines. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$144,000.00/yr - $180,000.00/yr Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancer harboring mutations in the RAS signaling pathway. The Opportunity: The
DMPK Senior Scientist I
will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department. Specifically, you will: Participate in the discovery of novel tri-complex inhibitors of frontier oncology targets by planning and implementing DMPK strategies to drive key project decisions for advancing small molecule programs. E.g. soft-spot analysis in optimization of molecules with improved metabolic stability or permeability. Maintain sufficient knowledge of principles and theories to serve as a DMPK technical lead on multi-disciplinary project teams. Design, manage and trouble-shoot mechanistic in vitro ADME and PK studies in a timely manner, and discuss results and potential solutions/implications at internal meetings. Conduct innovative research to understand the underlying principles of drug absorption, distribution, and elimination of RevMed TCI compounds by generating hypotheses from available data and literature. Incorporate new concepts and experimental techniques to develop novel in vitro ADME assays and refine IVIVE approaches. Collaborate with external functions to provide input and guidance on the translation of nonclinical PK/PD, PK-efficacy and PK-safety relationships to humans. Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies. Build and maintain strong collaborative partnerships across external functional areas, e.g., Medicinal chemistry, Biology, Cancer Pharmacology, Clinical Pharmacology. Required Skills, Experience, and Education: A highly motivated individual with a PhD in Pharmaceutic Sciences or a related scientific discipline, with 5 years of experience after graduation. Solid knowledge and experience in the ADME/PK concepts and basic compartmental modeling software. Prior experience with small molecule drug discovery programs experience working as a DMPK functional representative on cross-functional project teams. Complete understanding of early- through late-stage development and commercial advancement. Excellent verbal and written communication, problem-solving and critical thinking skills. Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment. Preferred Skills: Prior experience with oncology drug development. Industry experience of drug development is preferred. The base salary range for this full-time position is $144,000 to $180,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
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Senior Scientist I, DMPK
role at
Revolution Medicines 3 days ago Be among the first 25 applicants Join to apply for the
Senior Scientist I, DMPK
role at
Revolution Medicines This range is provided by Revolution Medicines. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$144,000.00/yr - $180,000.00/yr Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancer harboring mutations in the RAS signaling pathway. The Opportunity: The
DMPK Senior Scientist I
will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department. Specifically, you will: Participate in the discovery of novel tri-complex inhibitors of frontier oncology targets by planning and implementing DMPK strategies to drive key project decisions for advancing small molecule programs. E.g. soft-spot analysis in optimization of molecules with improved metabolic stability or permeability. Maintain sufficient knowledge of principles and theories to serve as a DMPK technical lead on multi-disciplinary project teams. Design, manage and trouble-shoot mechanistic in vitro ADME and PK studies in a timely manner, and discuss results and potential solutions/implications at internal meetings. Conduct innovative research to understand the underlying principles of drug absorption, distribution, and elimination of RevMed TCI compounds by generating hypotheses from available data and literature. Incorporate new concepts and experimental techniques to develop novel in vitro ADME assays and refine IVIVE approaches. Collaborate with external functions to provide input and guidance on the translation of nonclinical PK/PD, PK-efficacy and PK-safety relationships to humans. Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies. Build and maintain strong collaborative partnerships across external functional areas, e.g., Medicinal chemistry, Biology, Cancer Pharmacology, Clinical Pharmacology. Required Skills, Experience, and Education: A highly motivated individual with a PhD in Pharmaceutic Sciences or a related scientific discipline, with 5 years of experience after graduation. Solid knowledge and experience in the ADME/PK concepts and basic compartmental modeling software. Prior experience with small molecule drug discovery programs experience working as a DMPK functional representative on cross-functional project teams. Complete understanding of early- through late-stage development and commercial advancement. Excellent verbal and written communication, problem-solving and critical thinking skills. Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment. Preferred Skills: Prior experience with oncology drug development. Industry experience of drug development is preferred. The base salary range for this full-time position is $144,000 to $180,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research and Science Referrals increase your chances of interviewing at Revolution Medicines by 2x Get notified about new Senior Scientist jobs in
San Francisco Bay Area . United States $150,000 - $170,000 3 days ago San Francisco Bay Area $111,000 - $170,000 2 weeks ago Senior Staff Scientist, Computational Chemistry
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Brisbane, CA $177,400.00 - $219,100.00 13 hours ago Senior Decision Scientist - Growth Marketing
San Jose, CA $120,000.00 - $175,000.00 1 day ago Associate Director / Senior Scientist, Product Development
Sr. Staff Scientist, Analytical Development
Associate Director / Senior Scientist, Product Development- 618619
San Mateo, CA $170,000.00 - $200,000.00 3 weeks ago San Francisco, CA $166,000.00 - $272,400.00 2 weeks ago Principal/Senior Scientist, Analytical Science
Senior Staff Scientist, Medicinal Chemistry (industry experience required)
South San Francisco, CA $156,000.00 - $296,500.00 2 weeks ago Scientist II or Senior Scientist: Mass Spectrometry
Santa Cruz, CA $125,000.00 - $172,000.00 5 hours ago Senior Principal Research Scientist, Analytical Chemistry
South San Francisco, CA $156,000.00 - $296,500.00 2 weeks ago Sr. Scientist, Small-Molecule Drug Substance Development and Manufacturing
Hayward, CA $150,000.00 - $170,000.00 2 days ago Senior Scientist II, Analytical Development
Principal Scientist – Biomarker Development and Translational Research
Senior Scientist - Chemical Development and Drug Substance Manufacturing
RESEARCH SCIENTIST SUPERVISOR I (CHEMICAL SCIENCES)
Alameda, CA $9,254.00 - $11,868.00 3 weeks ago Scientist 1/2/Senior Scientist, Analytical Development
Research And Development Scientist, Food Product / Process Developer
Senior Clinical Scientist (Ophthalmology)
Oakland, CA $125,000 - $190,000 1 week ago Dispersion Expert - Scientist I-III/Senior/Lead
Alameda County, CA $110,000 - $180,000 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
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