Revolution Medicines
Senior Scientist II, PBPK Modeler
Revolution Medicines, San Francisco, California, United States, 94199
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Senior Scientist II, PBPK Modeler
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Revolution Medicines 1 day ago Be among the first 25 applicants Join to apply for the
Senior Scientist II, PBPK Modeler
role at
Revolution Medicines Get AI-powered advice on this job and more exclusive features. Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a passionate and experienced pharmacometrician with strong PBPK modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a key member of the pharmacometrics group, you will; Provide strong PBPK support as well as author technical reports and/or regulatory documents for major milestones of clinical development (EOP1/EOP2/NDA/sNDA). Lead the efforts of building internal PBPK workflow with FDA compliance and preparing submission-ready package. Work closely with DMPK and PDM colleagues to refine and validate PBPK models. Engage and work with consultants and/or CROs on pharmacometrics activities that complement in-house capabilities. Represent the pharmacometrics function in project teams and build strong working relationships with cross-functional teams. Required Skills, Experience and Education: A Ph.D. or Pharm.D. with 5+ years of relevant industry experience in PBPK. Solid knowledge about whole-body PBPK and hands-on experience in building PBPK models using SimCYP and PK-sim. Demonstrated experience and track record of using PBPK to support regulatory submissions (DDI, Special populations, etc.) and to address comments from regulatory agencies. Well-informed in current and emerging standards of regulatory requirements and expectations for pharmacometrics and clinical pharmacology. Able to take dynamically assigned pharmacometrics tasks and deliver the results in a timely manner. Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences. A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment. Preferred Skills: Prior experience with NDA/sNDA. Prior experience with small molecules in the oncology space. Proficiency in QSP and/or R programming. The base salary range for this full-time position is $164,000 to $205,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research and Science Industries Pharmaceutical Manufacturing Referrals increase your chances of interviewing at Revolution Medicines by 2x Inferred from the description for this job
Medical insurance Vision insurance 401(k) Paid maternity leave Paid paternity leave Get notified when a new job is posted. Sign in to set job alerts for “Senior Scientist” roles.
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Senior Scientist II, PBPK Modeler
role at
Revolution Medicines 1 day ago Be among the first 25 applicants Join to apply for the
Senior Scientist II, PBPK Modeler
role at
Revolution Medicines Get AI-powered advice on this job and more exclusive features. Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a passionate and experienced pharmacometrician with strong PBPK modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a key member of the pharmacometrics group, you will; Provide strong PBPK support as well as author technical reports and/or regulatory documents for major milestones of clinical development (EOP1/EOP2/NDA/sNDA). Lead the efforts of building internal PBPK workflow with FDA compliance and preparing submission-ready package. Work closely with DMPK and PDM colleagues to refine and validate PBPK models. Engage and work with consultants and/or CROs on pharmacometrics activities that complement in-house capabilities. Represent the pharmacometrics function in project teams and build strong working relationships with cross-functional teams. Required Skills, Experience and Education: A Ph.D. or Pharm.D. with 5+ years of relevant industry experience in PBPK. Solid knowledge about whole-body PBPK and hands-on experience in building PBPK models using SimCYP and PK-sim. Demonstrated experience and track record of using PBPK to support regulatory submissions (DDI, Special populations, etc.) and to address comments from regulatory agencies. Well-informed in current and emerging standards of regulatory requirements and expectations for pharmacometrics and clinical pharmacology. Able to take dynamically assigned pharmacometrics tasks and deliver the results in a timely manner. Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences. A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment. Preferred Skills: Prior experience with NDA/sNDA. Prior experience with small molecules in the oncology space. Proficiency in QSP and/or R programming. The base salary range for this full-time position is $164,000 to $205,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research and Science Industries Pharmaceutical Manufacturing Referrals increase your chances of interviewing at Revolution Medicines by 2x Inferred from the description for this job
Medical insurance Vision insurance 401(k) Paid maternity leave Paid paternity leave Get notified when a new job is posted. Sign in to set job alerts for “Senior Scientist” roles.
Newark, CA $150,000.00-$175,000.00 1 week ago Menlo Park, CA $100,000.00-$150,000.00 2 weeks ago Fremont, CA $110,000.00-$115,000.00 2 weeks ago Scientist/Senior Scientist, Analytical Chemistry
San Mateo County, CA $75.00-$85.00 1 week ago Scientist/Senior Scientist, Analytical Chemistry
Hayward, CA $85,000.00-$100,000.00 2 weeks ago Principal/Senior Scientist, Analytical Science
Senior Staff Scientist, Medicinal Chemistry (industry experience required)
South San Francisco, CA $170,000.00-$180,000.00 2 weeks ago Senior Scientist I, Biologics Drug Substance Development (Cell Culture Development)
South San Francisco, CA $94,000.00-$178,500.00 5 days ago Scientist II or Senior Scientist: Mass Spectrometry
Santa Cruz, CA $125,000.00-$172,000.00 3 weeks ago Senior Applied Scientist, Circuit and Fault Intelligence
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South San Francisco, CA $231,400.00-$364,200.00 17 hours ago Research Scientist - Computational Chemistry
Oakland, CA $150,000.00-$200,000.00 1 month ago Senior Scientist (Analytical Development CMC)
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Assoc Scientist R&D, RNA Assay Development
San Francisco, CA $300,000.00-$450,000.00 1 day ago Brisbane, CA $140,250.00-$216,500.00 4 days ago Scientist 1/2/Senior Scientist, Analytical Development
Palo Alto, CA $170,000.00-$190,000.00 11 hours ago Principal II Scientist, Applied Chemistry
Oakland, CA $125,000.00-$190,000.00 6 days ago San Francisco, CA $160,000.00-$210,000.00 3 weeks ago Senior Scientist I, Analytical Development
Santa Clara, CA $86,700.00-$173,300.00 5 days ago Senior Scientist, Quality Control Biologics (Analytical Lifecycle Management)
San Francisco Bay Area $157,590.00-$203,940.00 2 weeks ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr