Takeda Digital Ventures
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PBPK Modeling – Senior Scientist
role at
Takeda Digital Ventures 1 month ago Be among the first 25 applicants Join to apply for the
PBPK Modeling – Senior Scientist
role at
Takeda Digital Ventures Get AI-powered advice on this job and more exclusive features. Job Level: Senior Travel: Minimal (if any)
At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.
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Job ID
R0153168
Date posted
05/26/2025
Location
Boston, Massachusetts
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:
.
The Global Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) department at Takeda is seeking a strong candidate to be a part of the Physiologically Based Pharmacokinetic (PBPK) modeling team for supporting drug-drug interaction (DDI) and PK prediction in Takeda’s global research and development pipeline for all therapeutic areas The candidate is expected to have demonstrated experience in conducting PBPK modeling using Simcyp, Gastroplus, PKSim or other relevant software
Accountabilities
A successful candidate will be responsible for the design and implementation of PBPK models for small molecules and biotherapeutics supporting discovery and development programs. The accountabilities of this role include but are not limited to –
Develop the PBPK framework for preclinical species and humans in Simcyp, Gastroplus, Matlab, Phoenix or other relevant software Apply the models to new chemical entities for understanding tissue distribution to inform drug-target coverage and safety margins, predicting absorption and PK, and evaluating the impact of drug-drug interactions Predict PK in special populations (e.g. hepatic or renal impairment patients, pediatrics, pregnant population, diseased population, etc.) As required, develop novel PBPK models to answer mechanistic questions. Collaborate with multi-functional project teams and functional group colleagues to identify data requirements for model development, and strategies for model application and use.
Education & Competencies (Technical And Behavioral)
PhD degree with 3+ years relevant experience, Or MS with 9+ years relevant experience, or BS with 11+ years relevant experience in Pharmaceutical Sciences, Drug Metabolism and Pharmacokinetics, Pharmacology or other relevant field Strong understanding of the concepts of, and prior experience in PBPK modeling Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of diverse modalities (e.g. small molecules, biotherapeutics), biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential Proficient in one or more of the following modeling and simulation software – Simcyp, Gastroplus, PK-Sim, Matlab and/or Simbiology, R, Phoenix, Berkley Madonna, ADAPT, Mathematica or other relevant software Track record of publication and / or conference presentations Exceptional interpersonal, verbal communication and writing skills Good organizational and planning skills Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity Strong quantitative, analytical and problem-solving skills Global mindset to grow in a diverse work environment
Takeda Compensation And Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range
$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Apply Now
Back to nav Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Venture Capital and Private Equity Principals Referrals increase your chances of interviewing at Takeda Digital Ventures by 2x Get notified about new Senior Scientist jobs in
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PBPK Modeling – Senior Scientist
role at
Takeda Digital Ventures 1 month ago Be among the first 25 applicants Join to apply for the
PBPK Modeling – Senior Scientist
role at
Takeda Digital Ventures Get AI-powered advice on this job and more exclusive features. Job Level: Senior Travel: Minimal (if any)
At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.
Back to nav
Job ID
R0153168
Date posted
05/26/2025
Location
Boston, Massachusetts
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:
.
The Global Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) department at Takeda is seeking a strong candidate to be a part of the Physiologically Based Pharmacokinetic (PBPK) modeling team for supporting drug-drug interaction (DDI) and PK prediction in Takeda’s global research and development pipeline for all therapeutic areas The candidate is expected to have demonstrated experience in conducting PBPK modeling using Simcyp, Gastroplus, PKSim or other relevant software
Accountabilities
A successful candidate will be responsible for the design and implementation of PBPK models for small molecules and biotherapeutics supporting discovery and development programs. The accountabilities of this role include but are not limited to –
Develop the PBPK framework for preclinical species and humans in Simcyp, Gastroplus, Matlab, Phoenix or other relevant software Apply the models to new chemical entities for understanding tissue distribution to inform drug-target coverage and safety margins, predicting absorption and PK, and evaluating the impact of drug-drug interactions Predict PK in special populations (e.g. hepatic or renal impairment patients, pediatrics, pregnant population, diseased population, etc.) As required, develop novel PBPK models to answer mechanistic questions. Collaborate with multi-functional project teams and functional group colleagues to identify data requirements for model development, and strategies for model application and use.
Education & Competencies (Technical And Behavioral)
PhD degree with 3+ years relevant experience, Or MS with 9+ years relevant experience, or BS with 11+ years relevant experience in Pharmaceutical Sciences, Drug Metabolism and Pharmacokinetics, Pharmacology or other relevant field Strong understanding of the concepts of, and prior experience in PBPK modeling Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of diverse modalities (e.g. small molecules, biotherapeutics), biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential Proficient in one or more of the following modeling and simulation software – Simcyp, Gastroplus, PK-Sim, Matlab and/or Simbiology, R, Phoenix, Berkley Madonna, ADAPT, Mathematica or other relevant software Track record of publication and / or conference presentations Exceptional interpersonal, verbal communication and writing skills Good organizational and planning skills Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity Strong quantitative, analytical and problem-solving skills Global mindset to grow in a diverse work environment
Takeda Compensation And Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range
$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Apply Now
Back to nav Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Venture Capital and Private Equity Principals Referrals increase your chances of interviewing at Takeda Digital Ventures by 2x Get notified about new Senior Scientist jobs in
Boston, MA . Scientist/Sr. Scientist, Translational Development
Woburn, MA $130,000.00-$190,000.00 3 weeks ago Waltham, MA $175,000.00-$200,000.00 1 week ago Scientist - Process Research & Development
Cambridge, MA $156,000.00-$296,500.00 1 week ago Waltham, MA $160,000.00-$190,000.00 4 weeks ago Boston, MA $160,800.00-$241,200.00 5 days ago Cambridge, MA $95,000.00-$105,000.00 1 month ago Sr./Principal Scientist, Computational Chemistry
Cambridge, MA $145,000.00-$200,000.00 3 weeks ago Computational Chemistry Senior Research Scientist
Boston, MA $123,400.00-$185,100.00 2 weeks ago Senior Scientist, Translational Development
Senior Scientist, Pharmaceutical Development CMC (CONTRACT)
Senior Scientist Translational Gene editing Development with AAV, Gene and Cell Therapeutics Platform Research Organization
Principal Scientist, Drug Substance Process Development
Senior Scientist, Analytical Development - Drug Substance
Senior Principal Scientist, Development DMPK
Senior Scientist, Analytical Development (AD)
Lexington, MA $137,000.00-$215,270.00 6 days ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr