Flagship Pioneering
Scientist, Immunology
FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. FL87, Inc was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. We are seeking a highly motivated Scientist I / II of Immunology with expertise in T cell biology to join our therapeutic discovery team. The candidate will focus on hands-on benchwork using in vitro and ex vivo experimental approaches. This position requires scientific and technical expertise, and experience with pre-clinical disease models, scientific curiosity, and the desire to overcome scientific challenges and drive excellence. This individual will have the opportunity to be a major contributor to our lead program and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team. Key responsibilities include: Design and execute complex in vitro assays to evaluate CAR-T cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts Design and execute in vivo studies, including mice and NHPs. Conduct ex vivo analysis of immune cells Develop, optimize and troubleshoot experimental protocols, and maintain accurate and timely electronic laboratory notebook records Analyze, interpret and communicate experimental data at lab and project team meetings Comfortable working both as independent contributor and as part of a collaborative, multidisciplinary team of scientists Qualifications include: Ph.D. in Immunology or related field with 0-2 years of industry experience. Title will be commensurate with experience Deep expertise in flow cytometry, including panel design, instrument setup, and data analysis Experience handing primary T cells, human PBMC, and associated assays to determine T cell function and phenotype Experience with mouse models and ex vivo tissue processing and analyses. Experience in humanized mouse models and NHP ex vivo analyses is preferred Familiarity or experience with CAR-T and T cell engagers is preferred Experience with non-viral delivery technologies and nucleic acid modalities is preferred Highly motivated to execute at the bench, exceptional organizational, problem-solving, communication, and collaboration skills At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. FL87, Inc was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. We are seeking a highly motivated Scientist I / II of Immunology with expertise in T cell biology to join our therapeutic discovery team. The candidate will focus on hands-on benchwork using in vitro and ex vivo experimental approaches. This position requires scientific and technical expertise, and experience with pre-clinical disease models, scientific curiosity, and the desire to overcome scientific challenges and drive excellence. This individual will have the opportunity to be a major contributor to our lead program and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team. Key responsibilities include: Design and execute complex in vitro assays to evaluate CAR-T cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts Design and execute in vivo studies, including mice and NHPs. Conduct ex vivo analysis of immune cells Develop, optimize and troubleshoot experimental protocols, and maintain accurate and timely electronic laboratory notebook records Analyze, interpret and communicate experimental data at lab and project team meetings Comfortable working both as independent contributor and as part of a collaborative, multidisciplinary team of scientists Qualifications include: Ph.D. in Immunology or related field with 0-2 years of industry experience. Title will be commensurate with experience Deep expertise in flow cytometry, including panel design, instrument setup, and data analysis Experience handing primary T cells, human PBMC, and associated assays to determine T cell function and phenotype Experience with mouse models and ex vivo tissue processing and analyses. Experience in humanized mouse models and NHP ex vivo analyses is preferred Familiarity or experience with CAR-T and T cell engagers is preferred Experience with non-viral delivery technologies and nucleic acid modalities is preferred Highly motivated to execute at the bench, exceptional organizational, problem-solving, communication, and collaboration skills At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.