CHARMM-GUI
Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology
CHARMM-GUI, San Diego, California, United States, 92189
CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest. - M. Karplus
Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology Date 2021-03-04
Location San Diego, CA; Scripps Research
Description Mravic Lab @ The Scripps Research Institute, La Jolla, CA campus
Title Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology
Contact Apply to Dr. Mravic at
mmravic@scripps.edu
with a cover letter, CV with publication list, and contact information for 3 references. Unpublished first-author manuscripts can be included for review. More info on lab website:
https://www.scripps.edu/mravic/
Research Areas
Design and characterization of synthetic membrane proteins:
Using protein design to hypothesize and test chemical rules and features for protein structure or function in lipid. Focuses on creating simplified membrane protein models to understand disease mechanisms, improve in silico prediction, and enable bioengineering applications.
Design of chemical biology tools:
Developing computational algorithms to design hydrophobic mini-proteins and peptides that insert into lipid bilayers and target membrane proteins at their transmembrane regions. These tools help manipulate protein states and study disease mechanisms for therapeutic insights.
The lab employs computational methods like bioinformatics, modeling, and molecular dynamics, alongside experimental techniques such as NMR, X-ray crystallography, lipid cubic phase crystallography, chemical synthesis, bioconjugation, and cellular assays. Candidates with additional skills like cryo-EM are encouraged to apply.
Basic Qualifications
Molecular cloning, mammalian cell culture, protein expression & purification
Biophysical and structural characterization of proteins (FRET, NMR, Cryo-EM, X-ray)
Computational biology and programming (Python, Perl, Bash, C++)
Proven research productivity with peer-reviewed publications
Preferred Qualifications
Experience with membrane protein expression, purification, and structural biology
Computational biophysics, high-performance computing, GPU acceleration
Proficiency with molecular modeling and simulation software
Skills in bioinformatics, statistics, clustering, machine learning
How to Apply Send your application to Dr. Mravic at
mmravic@scripps.edu
with a cover letter, CV, publication list, and contact info for 3 references. Unpublished manuscripts are welcome. More info available on the lab website.
#J-18808-Ljbffr
Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology Date 2021-03-04
Location San Diego, CA; Scripps Research
Description Mravic Lab @ The Scripps Research Institute, La Jolla, CA campus
Title Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology
Contact Apply to Dr. Mravic at
mmravic@scripps.edu
with a cover letter, CV with publication list, and contact information for 3 references. Unpublished first-author manuscripts can be included for review. More info on lab website:
https://www.scripps.edu/mravic/
Research Areas
Design and characterization of synthetic membrane proteins:
Using protein design to hypothesize and test chemical rules and features for protein structure or function in lipid. Focuses on creating simplified membrane protein models to understand disease mechanisms, improve in silico prediction, and enable bioengineering applications.
Design of chemical biology tools:
Developing computational algorithms to design hydrophobic mini-proteins and peptides that insert into lipid bilayers and target membrane proteins at their transmembrane regions. These tools help manipulate protein states and study disease mechanisms for therapeutic insights.
The lab employs computational methods like bioinformatics, modeling, and molecular dynamics, alongside experimental techniques such as NMR, X-ray crystallography, lipid cubic phase crystallography, chemical synthesis, bioconjugation, and cellular assays. Candidates with additional skills like cryo-EM are encouraged to apply.
Basic Qualifications
Molecular cloning, mammalian cell culture, protein expression & purification
Biophysical and structural characterization of proteins (FRET, NMR, Cryo-EM, X-ray)
Computational biology and programming (Python, Perl, Bash, C++)
Proven research productivity with peer-reviewed publications
Preferred Qualifications
Experience with membrane protein expression, purification, and structural biology
Computational biophysics, high-performance computing, GPU acceleration
Proficiency with molecular modeling and simulation software
Skills in bioinformatics, statistics, clustering, machine learning
How to Apply Send your application to Dr. Mravic at
mmravic@scripps.edu
with a cover letter, CV, publication list, and contact info for 3 references. Unpublished manuscripts are welcome. More info available on the lab website.
#J-18808-Ljbffr