Altos Labs
Scientist/Senior Scientist, CNS Cell Biology and Light Microscopy
Altos Labs, San Francisco, California, United States, 94199
Scientist/Senior Scientist, CNS Cell Biology and Light Microscopy Our Mission
Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. Diversity at Altos
We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos
As an individual contributor and Scientist at the Bay Area Institute of Science, you will play a key role in advancing Altos' scientific programs about brain aging and neurodegeneration. Working closely with the Frost lab, you will be responsible for designing and implementing innovative experimental approaches using metabolic and light microscopy techniques. This includes developing and utilizing cell types derived from the central nervous system (CNS), applying genetic perturbations to these cells, and employing experimental approaches that include light microscopy and metabolic profiling. The ideal candidate will possess a robust understanding of CNS cell biology, the metabolic shifts characteristic of aging and neurodegenerative diseases, and proficiency in advanced microscopy, image analysis and metabolism techniques. This role reports to Principal Investigator Adam Frost. Responsibilities Provide advanced cell culture, metabolic, and genetic manipulation of iPSC-derived CNS cell types and primary CNS cells. Provide independent design and implementation of all phases of light microscopy experimentation, including experimental design, microscope operation, image capture, and quantitative image analysis. Engage with cross-Altos research labs to bridge in vitro with in vivo models and to suggest complementary genetic and morphological profiling approaches. Stay abreast of advances in light microscopy methods and technologies so that these can be brought to Altos as needed. Assist other scientists in the Frost group and beyond in quantitative analysis of microscope images using tools such as Zen, Elements, Arivis, Napari, Fiji, and other software. When appropriate, manage image analysis collaborations with the Computer Vision team. Who You Are
PhD in a related field, such as Cell Biology, Neuroscience, Genetics Thorough understanding of the principles of light microscopy image visualization, analysis, and processing. Demonstrable understanding of cell metabolism, including the impact of metabolism on chromatin and cell fate. Excellent communication skills and proven ability to collaborate within a dynamic team. Preferred qualifications Primary CNS cell isolation and culture CRISPR-based genetic manipulation of mammalian cells Practical experience with the management of terabyte-size microscopy datasets Literacy in MATLAB, R, or Python Practical experience with cellular image segmentation tools #LI-NN1 The salary range for
Redwood City, CA Scientist I, Imaging Technologies: $ 127,500 - $172,500 Scientist I, Imaging Technologies: $150,000 - $ 205,200 Senior Scientist I, Imaging Technologies: $ 171,000 - $240,000 Senior Scientist II, Imaging Technologies:$ 200,000 - $282,000 Exact compensation may vary based on skills, experience, and location. - Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice )
A variety of soft skills and experience may be required for the following role Please ensure you check the overview below carefully. - This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. What We Want You To Know
We are a culture of collaboration and scientific excellence, and we believe in the values of inclusion and belonging to inspire innovation. Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief). Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging. Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/ Apply for this job * indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Employment Title * Select... Start date year * End date month * Select... End date year * Current role Education School * Select... Degree * Select... Select... Select... Start date year * End date month * Select... End date year * If you prefer to be addressed by a nickname that is different from the legal name you entered above, please list here * Full Permanent Physical Address (Street, City, Postal and Country) * LinkedIn Profile * Website Are you legally authorized to work in the job location on a full-time basis? * Select... Will you now or in the future require sponsorship for employment visa status? * Select... Are you any of the following: (a) a U.S. citizen, (b) a lawful permanent resident of the United States (i.e., a green card holder), or (c) a protected individual as defined by 8 U.S.C. 1324b(a)(3) (e.g., granted asylum or a refugee), or d) none of the above. * Select... If the answer to the previous question is ‘no’, is your most recent country of citizenship any of the following: Cuba, Iran, North Korea, or Syria? * Select... If needed for the position, are you willing to relocate? * Select... How did you hear about this position? * Select... Do you know anyone who works or is applying to work for Altos? * Select... If you said yes to the previous question, please list anyone you know who works or is applying to work for Altos. * Before submitting your application, please read the Altos Labs EU and UK Applicant Privacy Notice provided in the job posting. This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. * Select... I have reviewed the information I provided on my resume and in my job application, and I am confirming that all of the information listed is accurate. * Select... US Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary . Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Altos Labs's Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
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Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. Diversity at Altos
We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos
As an individual contributor and Scientist at the Bay Area Institute of Science, you will play a key role in advancing Altos' scientific programs about brain aging and neurodegeneration. Working closely with the Frost lab, you will be responsible for designing and implementing innovative experimental approaches using metabolic and light microscopy techniques. This includes developing and utilizing cell types derived from the central nervous system (CNS), applying genetic perturbations to these cells, and employing experimental approaches that include light microscopy and metabolic profiling. The ideal candidate will possess a robust understanding of CNS cell biology, the metabolic shifts characteristic of aging and neurodegenerative diseases, and proficiency in advanced microscopy, image analysis and metabolism techniques. This role reports to Principal Investigator Adam Frost. Responsibilities Provide advanced cell culture, metabolic, and genetic manipulation of iPSC-derived CNS cell types and primary CNS cells. Provide independent design and implementation of all phases of light microscopy experimentation, including experimental design, microscope operation, image capture, and quantitative image analysis. Engage with cross-Altos research labs to bridge in vitro with in vivo models and to suggest complementary genetic and morphological profiling approaches. Stay abreast of advances in light microscopy methods and technologies so that these can be brought to Altos as needed. Assist other scientists in the Frost group and beyond in quantitative analysis of microscope images using tools such as Zen, Elements, Arivis, Napari, Fiji, and other software. When appropriate, manage image analysis collaborations with the Computer Vision team. Who You Are
PhD in a related field, such as Cell Biology, Neuroscience, Genetics Thorough understanding of the principles of light microscopy image visualization, analysis, and processing. Demonstrable understanding of cell metabolism, including the impact of metabolism on chromatin and cell fate. Excellent communication skills and proven ability to collaborate within a dynamic team. Preferred qualifications Primary CNS cell isolation and culture CRISPR-based genetic manipulation of mammalian cells Practical experience with the management of terabyte-size microscopy datasets Literacy in MATLAB, R, or Python Practical experience with cellular image segmentation tools #LI-NN1 The salary range for
Redwood City, CA Scientist I, Imaging Technologies: $ 127,500 - $172,500 Scientist I, Imaging Technologies: $150,000 - $ 205,200 Senior Scientist I, Imaging Technologies: $ 171,000 - $240,000 Senior Scientist II, Imaging Technologies:$ 200,000 - $282,000 Exact compensation may vary based on skills, experience, and location. - Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice )
A variety of soft skills and experience may be required for the following role Please ensure you check the overview below carefully. - This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. What We Want You To Know
We are a culture of collaboration and scientific excellence, and we believe in the values of inclusion and belonging to inspire innovation. Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief). Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging. Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/ Apply for this job * indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Employment Title * Select... Start date year * End date month * Select... End date year * Current role Education School * Select... Degree * Select... Select... Select... Start date year * End date month * Select... End date year * If you prefer to be addressed by a nickname that is different from the legal name you entered above, please list here * Full Permanent Physical Address (Street, City, Postal and Country) * LinkedIn Profile * Website Are you legally authorized to work in the job location on a full-time basis? * Select... Will you now or in the future require sponsorship for employment visa status? * Select... Are you any of the following: (a) a U.S. citizen, (b) a lawful permanent resident of the United States (i.e., a green card holder), or (c) a protected individual as defined by 8 U.S.C. 1324b(a)(3) (e.g., granted asylum or a refugee), or d) none of the above. * Select... If the answer to the previous question is ‘no’, is your most recent country of citizenship any of the following: Cuba, Iran, North Korea, or Syria? * Select... If needed for the position, are you willing to relocate? * Select... How did you hear about this position? * Select... Do you know anyone who works or is applying to work for Altos? * Select... If you said yes to the previous question, please list anyone you know who works or is applying to work for Altos. * Before submitting your application, please read the Altos Labs EU and UK Applicant Privacy Notice provided in the job posting. This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. * Select... I have reviewed the information I provided on my resume and in my job application, and I am confirming that all of the information listed is accurate. * Select... US Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary . Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Altos Labs's Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
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