Gilead Sciences, Inc.
Associate Scientist - Oncology
Gilead Sciences, Inc., Foster City, California, United States, 94420
Job Description
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
The Oncology department at Gilead Sciences is seeking an experienced and motivated Associate Scientist with exceptional technical skills to support research programs focused on the discovery and development of novel therapies that mobilize the immune response against cancer. The successful candidate will be instrumental in leading cell engineering efforts, including generation of genetically modified cell lines and conducting experiments to help develop novel assays to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors. Our highly diverse, collaborative, and interdisciplinary research teams utilize state-of-the-art technologies and innovative methodologies to advance novel immuno-oncology therapies into the clinic. The position has ample opportunities for career growth through acquisition of new skills, experiences, and professional relationships in an inclusive, fast-paced, and resource-rich environment. The successful candidate will contribute to therapeutic candidate characterization in immune cell-mediated killing assays, new admixed immune cells / cancer cells assay development, mechanism of action studies, and flow cytometry-based immune profiling/phenotyping studies in vitro and from dissociated mouse tumor samples. Key Responsibilities Primary responsibility to support target validation efforts through characterization and generation of cellular models, including genetically modified cell lines (CRISPR knock-out) and overexpressing cell lines, with contributions to multiple projects Explore mechanism of action of immune engager molecules by characterizing mouse surrogate molecules, developing genetically engineered mouse cancer cell lines Help develop novel, complex cell biology assays to model tumor biology more physiologically than traditional cell culture systems (organoid, sequential killing assays) Prepare and present findings to the team and at department-wide meetings Contribute figures to research reports, manuscripts, INDs, and patent filings Knowledge, Experience and Skills Industry research experience preferred (BS +4 years
OR
MS +2 years) in cancer immunology or related field with a record of achievements (publications) Proficiency with cell culture methods Experience with gene knockdown (RNAi), knockout (CRISPR/Cas9), and overexpression techniques (transfection, viral transduction) Experience with RNA and protein quantification techniques (RT-qPCR, Nanostring, MSD/ELISA, western) Basic flow cytometry skills, proficiency with multi-parametric Flow Cytometry experiments preferred Experience in running and developing cell-based assays (ADCC or T cell-mediated killing assays, Jurkat reporter assays, etc…) Independently execute and analyze studies Great attention to detail with excellent organizational and record keeping skills Strong motivation, independence, and ability to think critically and act creatively to resolve problems Excellent communication and interpersonal skills and ability to integrate into a high-paced multidisciplinary environment
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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
The Oncology department at Gilead Sciences is seeking an experienced and motivated Associate Scientist with exceptional technical skills to support research programs focused on the discovery and development of novel therapies that mobilize the immune response against cancer. The successful candidate will be instrumental in leading cell engineering efforts, including generation of genetically modified cell lines and conducting experiments to help develop novel assays to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors. Our highly diverse, collaborative, and interdisciplinary research teams utilize state-of-the-art technologies and innovative methodologies to advance novel immuno-oncology therapies into the clinic. The position has ample opportunities for career growth through acquisition of new skills, experiences, and professional relationships in an inclusive, fast-paced, and resource-rich environment. The successful candidate will contribute to therapeutic candidate characterization in immune cell-mediated killing assays, new admixed immune cells / cancer cells assay development, mechanism of action studies, and flow cytometry-based immune profiling/phenotyping studies in vitro and from dissociated mouse tumor samples. Key Responsibilities Primary responsibility to support target validation efforts through characterization and generation of cellular models, including genetically modified cell lines (CRISPR knock-out) and overexpressing cell lines, with contributions to multiple projects Explore mechanism of action of immune engager molecules by characterizing mouse surrogate molecules, developing genetically engineered mouse cancer cell lines Help develop novel, complex cell biology assays to model tumor biology more physiologically than traditional cell culture systems (organoid, sequential killing assays) Prepare and present findings to the team and at department-wide meetings Contribute figures to research reports, manuscripts, INDs, and patent filings Knowledge, Experience and Skills Industry research experience preferred (BS +4 years
OR
MS +2 years) in cancer immunology or related field with a record of achievements (publications) Proficiency with cell culture methods Experience with gene knockdown (RNAi), knockout (CRISPR/Cas9), and overexpression techniques (transfection, viral transduction) Experience with RNA and protein quantification techniques (RT-qPCR, Nanostring, MSD/ELISA, western) Basic flow cytometry skills, proficiency with multi-parametric Flow Cytometry experiments preferred Experience in running and developing cell-based assays (ADCC or T cell-mediated killing assays, Jurkat reporter assays, etc…) Independently execute and analyze studies Great attention to detail with excellent organizational and record keeping skills Strong motivation, independence, and ability to think critically and act creatively to resolve problems Excellent communication and interpersonal skills and ability to integrate into a high-paced multidisciplinary environment
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