Computational Chemistry Senior Research Scientist
Join to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals
Computational Chemistry Senior Research Scientist
Join to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals
Job Description
Research Scientist, Computational Drug Design
General Summary
We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively with the global Data and Computational Sciences group to provide expertise in data analysis, cheminformatics, and physics-based methods development. Thus, this individual must demonstrate strong interpersonal skills and have demonstrated the ability to guide scientists in drug discovery.
Job Description
Research Scientist, Computational Drug Design
General Summary
We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively with the global Data and Computational Sciences group to provide expertise in data analysis, cheminformatics, and physics-based methods development. Thus, this individual must demonstrate strong interpersonal skills and have demonstrated the ability to guide scientists in drug discovery.
Key Duties And Responsibilities
- Apply computational chemistry methods and tools to accelerate the discovery and development of drug candidates, in close collaboration with chemists, structural biologists, biologists and other research project scientists
- Use timely decision making to ensure focus and delivery of key project objectives. Promote high levels of productivity and urgency
- Leverage physics-based methods, generative models and machine learning approaches to design new chemical entities
- Proactively work with other computational chemists and cheminformaticians to assess and develop new computational methodologies, create workflows and share successful methods
- Contribute to the further development of Vertex’s computational chemistry capabilities with a focus on physics-based methods
- Seek out opportunities to improve Vertex’s global R&D capabilities through collaboration with DMPK, Structural Biology, Safety Assessment, and other groups
- Excellent interpersonal, communication and presentation skills
- In depth knowledge of physics-based methods and the state-of-the-art in computational chemistry and their application in drug discovery
- Experience with commercial and open-source molecular modeling and data mining software
- Knowledge of concepts related to drug discovery and development
- Strong solution-oriented attitude, spirit of innovation and creativity, good time and priority management
- Scripting and programming expertise in languages such as Python
- Ph.D. (or equivalent degree) in Computational Chemistry and 2-5 years of productive, relevant post-doctoral employment experience
- Experience in applying a wide array of molecular modeling methods to structure, ligand and fragment-based drug discovery projects
$123,400 - $185,100
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at
Seniority level
Seniority level
Mid-Senior level
Employment type
Employment type
Full-time
Job function
Job function
Other
Referrals increase your chances of interviewing at Vertex Pharmaceuticals by 2x
Get notified about new Senior Research Scientist jobs in Boston, MA .
Woburn, MA $130,000.00-$190,000.00 1 week ago
Principal Scientist , Analytical Science Lead
Cambridge, MA $156,000.00-$296,500.00 2 weeks ago
Sr./Principal Scientist, Computational Chemistry
Cambridge, MA $145,000.00-$200,000.00 2 weeks ago
Senior Principal Research Scientist, Analytical Chemistry
Cambridge, MA $156,000.00-$296,500.00 2 weeks ago
Principal Scientist, Computational Chemistry
Waltham, MA $160,000.00-$190,000.00 2 weeks ago
Principal Research Scientist II, Analytical Development (Onsite-Waltham, MA)
Waltham, MA $137,500.00-$261,000.00 4 days ago
Boston, MA $112,180.00-$162,662.50 8 hours ago
Boston, MA $281,300.00-$442,800.00 2 weeks ago
Cambridge, MA $122,250.00-$176,583.33 1 week ago
Senior Principal Research Scientist, Physics-Based Methods Development
Waltham, MA $100,000.00-$110,000.00 1 day ago
Associate Principal Scientist Pharmacology (Clinical) - Cell Therapy
Boston, MA $135,457.59-$203,186.41 2 weeks ago
Senior Quantum Scientist — Quantum Algorithms
Waltham, MA $100,000.00-$110,000.00 2 days ago
Senior Principal Scientist, Development DMPK
Senior Principal Research Scientist, Analytical Chemistry
Principal Scientist I, Imaging Expert- Clinical Imaging & Analytics
Cambridge, MA $103,600.00-$192,400.00 2 weeks ago
Sr. Scientist, Bioanalytical CRO Management, DMPK (Orexin Programs)
Principal Scientist II, Imaging Expert- Clinical Imaging & Analytics
Cambridge, MA $114,100.00-$211,900.00 2 weeks ago
Senior Principal Scientist, Lead Development Biomarker Studies,Translational Development
Principal Scientist, Radiopharmaceutical Development
Sr. Scientist, B Cell Biologist (Immunology)
Boston, MA $137,000.00-$215,270.00 2 weeks ago
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr