Kardigan, Inc.
Postdoc / Visiting Scientist – Bioengineering CV Research models
Kardigan, Inc., San Francisco, California, United States, 94199
Postdoc / Visiting Scientist – Bioengineering CV Research models
About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. Led by Tassos Giannakakos, Jay Edelberg, M.D. and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020. We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals.
Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in
being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an
eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to
winning as a team
with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to
enable the impossible
because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day. Position Title:
Postdoc / Visiting Scientist – Bioengineering CV Research models Department:
Research and Translational Sciences Scientific Mentor:
Scientist, Biochemistry Location: South San Francisco, CA – On-site 4 days per week (Mon to Thurs) Job Overview Kardigan is seeking a postdoc / visiting scientist with a bioengineering background to help us build physiologically relevant in vitro models to study a range of cardiovascular diseases. The project seeks to model cardiovascular health and disease into engineered heart tissue models. This will enable high- throughput multi-well mechanistic and physiological assessments in vitro. The tools developed and the mechanistic and functional insights discovered under the project will enable the next generation of therapies from the Kardigan pipeline. Ultimately, the project aims to train the next generation of translational scientists in modern cardiovascular drug discovery and development within industry settings. This will not only expand the pool of well-trained scientists available to industry but also foster future partnerships between academic research and industry. The position would be based in South San Francisco, CA. Short travel nationally may be required as part of our academic collaborations. Essential Duties and Responsibilities Design, fabricate, and optimize 3D EHT constructs using atrial, ventricular myocardium, and aortic valve leaflets. Integrate various cell types (e.g., iPSC-derived cardiomyocytes, fibroblasts, valvular cells) into tissue constructs and in vitro models. Ensure tissue viability, maturation, and functional integrity over time. Perform in vitro functional measurements of contractility as well as tissue compliance/ stiffness. Analyze differences between healthy vs. disease models to understand pathophysiology and disease mechanism. Conduct immunohistochemistry, confocal microscopy, qPCR, and Western blotting to evaluate structural and functional markers. Conduct in vitro assay screening of Kardigan compounds. Perform quantitative analysis of biomechanical and molecular data, create reports and communicate findings to company-wide meetings. The project must lead to at least one scientific publication. Qualifications and Preferred Skills A PhD in Biomedical Engineering, Cardiac Physiology, Bioengineering, Cell Biology or related field. Strong background in Biomaterials is preferred. Research experience with engineered heart tissue (EHT) or 3D cardiac tissue models. Expertise in biomaterials, 3D printing, hydrogels and/or scaffold- based approaches is a requirement Familiarity with cell culture including induced pluripotent stem cell (iPSC) culture, cardiac differentiation and primary isolation and culture protocols is preferred but not required. Strong publication record in tissue engineering, cardiovascular research and/or mechanobiology. Ability to work independently as well as in cross functional teams. High energy, with a passion for fundamental disease understanding, quality drug development, and entrepreneurial spirit. Strong problem-solving capacity - enjoys complex challenges and has the accountability to deliver on ambitious, but realistic, business, and scientific goals. Excellent communication skills – ability to communicate science clearly and effectively to a broad range of audiences including non-specialists. Create a Job Alert Interested in building your career at Kardigan? Get future opportunities sent straight to your email. Apply for this job
indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School Select... Degree Select... Select... LinkedIn Profile Will you now or in the future require sponsorship to work in the United States? * Select... Are you willing to come into the office up to 4 days per week? (Kardigan offices located in South San Francisco, CA or Princeton, NJ) * Select... Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Kardigan’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Select... Voluntary Self-Identification of Disability
Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability?
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Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury
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About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. Led by Tassos Giannakakos, Jay Edelberg, M.D. and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020. We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals.
Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in
being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an
eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to
winning as a team
with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to
enable the impossible
because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day. Position Title:
Postdoc / Visiting Scientist – Bioengineering CV Research models Department:
Research and Translational Sciences Scientific Mentor:
Scientist, Biochemistry Location: South San Francisco, CA – On-site 4 days per week (Mon to Thurs) Job Overview Kardigan is seeking a postdoc / visiting scientist with a bioengineering background to help us build physiologically relevant in vitro models to study a range of cardiovascular diseases. The project seeks to model cardiovascular health and disease into engineered heart tissue models. This will enable high- throughput multi-well mechanistic and physiological assessments in vitro. The tools developed and the mechanistic and functional insights discovered under the project will enable the next generation of therapies from the Kardigan pipeline. Ultimately, the project aims to train the next generation of translational scientists in modern cardiovascular drug discovery and development within industry settings. This will not only expand the pool of well-trained scientists available to industry but also foster future partnerships between academic research and industry. The position would be based in South San Francisco, CA. Short travel nationally may be required as part of our academic collaborations. Essential Duties and Responsibilities Design, fabricate, and optimize 3D EHT constructs using atrial, ventricular myocardium, and aortic valve leaflets. Integrate various cell types (e.g., iPSC-derived cardiomyocytes, fibroblasts, valvular cells) into tissue constructs and in vitro models. Ensure tissue viability, maturation, and functional integrity over time. Perform in vitro functional measurements of contractility as well as tissue compliance/ stiffness. Analyze differences between healthy vs. disease models to understand pathophysiology and disease mechanism. Conduct immunohistochemistry, confocal microscopy, qPCR, and Western blotting to evaluate structural and functional markers. Conduct in vitro assay screening of Kardigan compounds. Perform quantitative analysis of biomechanical and molecular data, create reports and communicate findings to company-wide meetings. The project must lead to at least one scientific publication. Qualifications and Preferred Skills A PhD in Biomedical Engineering, Cardiac Physiology, Bioengineering, Cell Biology or related field. Strong background in Biomaterials is preferred. Research experience with engineered heart tissue (EHT) or 3D cardiac tissue models. Expertise in biomaterials, 3D printing, hydrogels and/or scaffold- based approaches is a requirement Familiarity with cell culture including induced pluripotent stem cell (iPSC) culture, cardiac differentiation and primary isolation and culture protocols is preferred but not required. Strong publication record in tissue engineering, cardiovascular research and/or mechanobiology. Ability to work independently as well as in cross functional teams. High energy, with a passion for fundamental disease understanding, quality drug development, and entrepreneurial spirit. Strong problem-solving capacity - enjoys complex challenges and has the accountability to deliver on ambitious, but realistic, business, and scientific goals. Excellent communication skills – ability to communicate science clearly and effectively to a broad range of audiences including non-specialists. Create a Job Alert Interested in building your career at Kardigan? Get future opportunities sent straight to your email. Apply for this job
indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School Select... Degree Select... Select... LinkedIn Profile Will you now or in the future require sponsorship to work in the United States? * Select... Are you willing to come into the office up to 4 days per week? (Kardigan offices located in South San Francisco, CA or Princeton, NJ) * Select... Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Kardigan’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Select... Voluntary Self-Identification of Disability
Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury
Disability Status Select... PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
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