Principal Scientist

OneDigital NorCal HR Consulting provided pay range

This range is provided by OneDigital NorCal HR Consulting. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$185,000.00/yr - $215,000.00/yr

**Posting for our client, Isotovia Biosciences **

We are looking for an outstanding Principal Scientist to join our Discovery team at Isotovia Biosciences, a new company in San Carlos. This individual will be a part of an integrated highly motivated team developing Attobody-based therapeutic molecules. As a vital member, the successful candidate will play a key role in building the foundation of the company’s Discovery organization. This is an on-site position.

Key Responsibilities:

• Responsible for Attobody discovery campaign using yeast and phage display technology, including design, execution and troubleshooting.
• Perform hands-on Attobody discovery workflow, from library construction, library panning, output screening, single clone attobody characterization and data analysis.
• Antibody characterization includes affinity and specificity determination, epitope binning and cell binding.
• Document and maintain ELN (Benchling) with accuracy in a timely manner
• Oversee outside vendors in matters related to protein production and characterization
• Conduct in-depth data analysis, communicate data efficiently in project meetings in line with project timeline and goals.
• Evaluate and assess new technologies and processes that could improve and streamline the discovery workflow.
• Analyze and interpret data, identify problems, and develop troubleshooting strategies.
• Proactively review scientific literature and provide strategic input and generate ideas for project
• Assesses the needs of a technology platform or Isotovia program and coordinates activities over multiple functions to fulfill company objectives and program goals.
• Performs other duties as assigned

Basic Qualifications:

• Master’s degree in biology or related field with a minimum of 10 plus years' experience in antibody discovery
• OR a PhD in Biology or related field with a minimum of 8 years' experience in antibody discovery
• Demonstrated ability to use and design in vitro antibody discovery display technologies (e.g., phage, yeast display) for discovery and/or engineering
• Sanger sequence analysis experience
• Excellent organizational skills and the ability to manage multiple projects simultaneously
• Demonstrated productivity and scientific independence with strong problem-solving skills.
• Desire to work in a dynamic startup environment is essential.

Preferred Qualifications:

• Strong communication skills to work within a multidisciplinary team environment.
• Direct experience with Carterra LSA, Biacore SPR, Octet BLI and flow cytometry (iQUE)
• Experience with robotic liquid handling systems is a plus.
• Knowledgeable in recombinant protein production and characterization
• Proficiency in GraphPad Prism, Geneious and Benchling
• Demonstrated track record in managing multiple projects and prioritizing tasks to meet

schedules and timelines.

• Excellent written and oral communication skills and the ability to present effectively to teams.
• Proven contribution to therapeutic antibody development and selection is desirable.

Salary range:

• $185,000-$215,000. The final salary offered is dependent on factors that may include but are not limited to the type and length of experience within the industry, education, etc.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science

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