Alnylam Pharmaceuticals
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Principal Scientist, Peptides
role at
Alnylam Pharmaceuticals
This position is
onsite
and will be primarily located in Cambridge, MA.
Overview The Medicinal Chemistry group is seeking a highly motivated and experienced Principal Scientist to join our dynamic team. This individual will be a key scientific leader responsible for driving the design, synthesis, and preclinical development of our peptide-based therapeutic candidates. The successful candidate will leverage their deep expertise in peptides to advance programs from lead optimization through to the selection of a development candidate for our delivery systems to different tissues.
Responsibilities
Provide critical scientific and strategic leadership for peptide projects, focusing on the development of scalable synthetic routes, robust purification processes, comprehensive analytical characterization methods and safety derisking.
Manage chemistry, conjugates, and oversee collaborations with external contract research organizations (CROs) and different companies on peptide screen and development.
Work in close collaboration with cross-functional teams including Biology, Pharmacology, toxicology, DMPK, and CMC to interpret data and collectively drive projects forward.
Advance a therapeutic peptide/conjugate through preclinical development.
Design, synthesis, and characterization of complex bioconjugates (preference for those who have worked on peptide oligonucleotide conjugates (POCs)).
Qualifications
PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related discipline with a minimum of 6-8 years of relevant experience in the pharmaceutical or biotechnology industry.
Proven track record of successfully advancing peptide/peptide conjugate therapeutic candidate through preclinical development, with significant contributions to CMC activities and IND-enabling studies.
Demonstrated expertise in modern synthetic chemistry, with a strong background in peptide chemistry (e.g., solid-phase peptide synthesis (SPPS), solution-phase synthesis, peptide modifications).
Extensive hands-on experience with the purification (e.g., preparative RP-HPLC) and analytical characterization of peptides and related molecules using techniques such as LC-MS, high-resolution MS, and NMR.
Experience managing projects and timelines, including overseeing the activities of external CROs/CMOs for process development, scale-up, and manufacturing of drug substance.
Strong problem-solving skills and the ability to think critically and creatively to overcome complex synthetic and analytical challenges.
Excellent communication and collaboration skills, with a demonstrated ability to work effectively in a cross-functional team environment and mentor junior scientists.
Preferred: Direct, hands-on experience in the design, synthesis, and characterization of bioconjugates, with a strong preference for experience with peptide oligonucleotide conjugates (POCs).
About Alnylam About Alnylam: We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
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Principal Scientist, Peptides
role at
Alnylam Pharmaceuticals
This position is
onsite
and will be primarily located in Cambridge, MA.
Overview The Medicinal Chemistry group is seeking a highly motivated and experienced Principal Scientist to join our dynamic team. This individual will be a key scientific leader responsible for driving the design, synthesis, and preclinical development of our peptide-based therapeutic candidates. The successful candidate will leverage their deep expertise in peptides to advance programs from lead optimization through to the selection of a development candidate for our delivery systems to different tissues.
Responsibilities
Provide critical scientific and strategic leadership for peptide projects, focusing on the development of scalable synthetic routes, robust purification processes, comprehensive analytical characterization methods and safety derisking.
Manage chemistry, conjugates, and oversee collaborations with external contract research organizations (CROs) and different companies on peptide screen and development.
Work in close collaboration with cross-functional teams including Biology, Pharmacology, toxicology, DMPK, and CMC to interpret data and collectively drive projects forward.
Advance a therapeutic peptide/conjugate through preclinical development.
Design, synthesis, and characterization of complex bioconjugates (preference for those who have worked on peptide oligonucleotide conjugates (POCs)).
Qualifications
PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related discipline with a minimum of 6-8 years of relevant experience in the pharmaceutical or biotechnology industry.
Proven track record of successfully advancing peptide/peptide conjugate therapeutic candidate through preclinical development, with significant contributions to CMC activities and IND-enabling studies.
Demonstrated expertise in modern synthetic chemistry, with a strong background in peptide chemistry (e.g., solid-phase peptide synthesis (SPPS), solution-phase synthesis, peptide modifications).
Extensive hands-on experience with the purification (e.g., preparative RP-HPLC) and analytical characterization of peptides and related molecules using techniques such as LC-MS, high-resolution MS, and NMR.
Experience managing projects and timelines, including overseeing the activities of external CROs/CMOs for process development, scale-up, and manufacturing of drug substance.
Strong problem-solving skills and the ability to think critically and creatively to overcome complex synthetic and analytical challenges.
Excellent communication and collaboration skills, with a demonstrated ability to work effectively in a cross-functional team environment and mentor junior scientists.
Preferred: Direct, hands-on experience in the design, synthesis, and characterization of bioconjugates, with a strong preference for experience with peptide oligonucleotide conjugates (POCs).
About Alnylam About Alnylam: We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
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