Overview
Head of US Commercial Operations at Dyne Therapeutics (posted on BioSpace). The company focuses on delivering functional improvement for people living with genetically driven neuromuscular diseases, developing therapeutics targeting muscle and the central nervous system (CNS). Lead programs include clinical efforts for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.
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Role Summary
The Head of US Commercial Operations will bring extensive experience to our product launches in neuromuscular disease, with an initial focus on launch readiness and commercialization of lead assets in Duchenne Muscular Dystrophy and myotonic dystrophy Type I (DM1). This is a strategic and hands-on leadership role responsible for building and managing critical commercial infrastructure, including sales operations, analytics, forecasting, market access operations, and commercial systems. The role oversees sales operations, forecasting and analytics, incentive compensation, US market research, data management, CRM systems, field effectiveness, and commercial training.
As part of a high-performing team, this role collaborates cross-functionally to deliver a one-Dyne approach, working with field roles, Marketing, Medical Affairs, Patient Services, Global Value and Access, Finance, and IT to ensure cohesive and aligned go-to-market strategies and successful execution. The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment. This role is based in Waltham, MA.
Primary Responsibilities
- Serve as a key member of the US Commercial Leadership Team, developing and executing commercial operations strategy and operating plans.
- Develop and execute the commercial operations infrastructure to support a successful rare disease product launch in DMD and DM1.
- Lead commercial planning processes, including sales forecasting, demand planning, incentive compensation design, and territory alignment.
- Build and oversee a high-functioning sales operations team and associated systems (CRM, data warehousing, reporting dashboards).
- Establish data governance processes and manage third-party vendors providing data (claims, specialty pharmacy, distribution).
- Partner cross-functionally with Marketing, Medical Affairs, Patient Services, Global Value and Access, Finance, and IT to ensure alignment of commercial operations with overall corporate goals.
- Design and manage KPIs and reporting frameworks to track performance and inform commercial decision-making.
- Lead field force enablement efforts, including CRM configuration, targeting, call planning, and field reporting.
- Support the development of compliant policies and processes for commercial activities in collaboration with Legal and Compliance teams.
- Manage operational budgets, contracts, and vendor relationships for commercial functions.
Education, Knowledge & Skill Requirements
- BA/BS degree required; advanced degree (MBA, PhD, PharmD) preferred
- 10+ years of progressive experience in commercial operations within the biopharmaceutical industry, including at least 5 years in a leadership role
- Proven track record of successfully launching and commercializing biotech products, with a strong understanding of the rare disease market
- Deep understanding of commercial data sources (e.g., specialty pharmacy, HUB services, patient services, claims data)
- Demonstrated success in building commercial infrastructure in a high-growth or startup environment
- Proven analytical and problem-solving skills with ability to analyze data, identify trends, and develop actionable recommendations
- Strong project management skills, attention to detail, and ability to lead cross-functional initiatives
- Excellent communication and leadership skills with a collaborative approach
- Enterprise mindset that brings culture and values to life in everyday activities
- Experience in a small, rapidly growing biotech with the ability to operate in a startup environment while maintaining a solutions-oriented mentality
Company Information & Equal Opportunity
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
Location
Based in Waltham, MA.
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