Overview
The Dana-Farber Cancer Institute is seeking a highly motivated and accomplished Research Scientist to join our state-of-the-art Structural Biology Core Facility, with a significant collaborative appointment in the Center for Therapeutic Discovery and Fischer Lab. This position offers an exciting opportunity for a Ph.D. scientist to leverage advanced expertise in structural and protein biochemistry to contribute to core capabilities and drug-discovery research projects.
Location: Boston, MA. The role involves cross-functional collaboration with medicinal chemists, biochemists, and cell and chemical biologists, and participation in departmental seminars.
Responsibilities
- Design expression constructs and perform recombinant protein expression & purification in various systems (bacterial, insect, mammalian).
- Characterize proteins biochemically and structurally; crystallize or freeze protein samples; collect X-ray datasets; determine high-resolution structures; analyze and present results.
- Collaborate with cross-functional teams to determine structures for novel targets and ligand-target pairs, including large multi-protein complexes.
- Maintain accurate records of experimental work and communicate results to project teams.
- Lead independent research projects to investigate molecular mechanisms of small molecule–protein interactions and support structure-based drug discovery.
- Develop and implement new technologies to enhance core capabilities and efficiency.
- Provide scientific guidance and mentorship to junior lab members as appropriate.
Qualifications
- Ph.D. in Biochemistry, Structural Biology, Molecular Biology, Chemical Biology, or a closely related field.
- Postdoctoral experience (2+ years strongly preferred) with a strong publication record demonstrating independent research capabilities.
- Extensive hands-on expertise in recombinant protein expression and purification using automated chromatography (e.g., AKTA or Bio-Rad); multi-gram scale experience is a plus.
- Experience with structural characterization of ligand–protein complexes is a plus.
- Demonstrated ability to design, lead, and independently execute complex scientific projects.
- Exceptional scientific communication skills, both written and oral.
- Strong collaborative spirit and ability to work in cross-functional, matrixed teams.
- Ability to manage multiple projects in a fast-paced environment.
About Dana-Farber
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in cancer research and patient care. We are committed to an inclusive, diverse, and equitable environment with a mission to reduce the burden of cancer for all. We collaborate with Harvard Medical School-affiliated hospitals and partners to advance treatment and education.
Equal Opportunity
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
Job Details
- Seniority level: Mid-Senior level
- Employment type: Full-time
- Job function: Other
- Industries: Hospitals and Health Care