Overview
Manifold Bio is seeking a creative and driven expert in protein analytics and antibody characterization to join our Protein Sciences team and help expand the frontiers of shuttle-enabled drug delivery. In this role, you will drive innovative projects to assess protein-protein interactions and molecule characteristics. You’ll develop screening methodologies and rational design approaches for determining affinities of epitope-paratope pairs in high throughput formats. You’ll also establish techniques to characterize protein stability and developability to guide lead selection and optimization. The data you generate will inform molecule selection and test article formulations for Manifold’s unique multiplexed in vivo screening platform. This position is central to advancing internal therapeutic programs and building datasets that support partnering and platform expansion. You will generate critical data for cross-functional program teams and serve as a core Protein Sciences team member, bringing strong protein analytics expertise and collaborative skills to develop Manifold\'s next generation of targeted biologics.
Responsibilities
- Think deeply about and drive projects to investigate binding kinetics of therapeutic proteins to their target of interest.
- Generate and deeply characterize individual binders to inform test article formulation strategies.
- Build pipelines to screen hundreds to thousands of binders, analyze data, and generate plots for dissemination to the broader team.
- Utilize Manifold’s in vivo multiplexing capabilities to assess in vivo performance of characterized molecules.
- Generate, interpret, and communicate high-quality, decision-enabling data to inform program strategy and therapeutic design.
- Collaborate cross-functionally to progress therapeutic programs.
- Maintain clear documentation, share findings in team meetings, and contribute to strategic discussions on program direction and platform development.
Required Qualifications
- PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or related field
- Proven expertise in protein analytics and protein-protein interactions utilizing techniques such as BLI, SPR, ELISA, aSEC, DLS, and CE-SDS/cIEF
- Proficiency in protein expression and characterization laboratory techniques
- Strong analytical skills and creative problem-solving abilities, with the capacity to develop novel approaches and drive innovation in complex scientific challenges
- Adaptable and proactive mindset with a track record of productivity and successfully translating innovative ideas into meaningful outcomes
- Strong communication skills and collaborative working style
Preferred Qualifications
- Industry experience developing therapeutic antibodies
- Previous experience working on brain shuttle technologies
- Background working with data from protein mass spectrometry
- Experience with performing analysis on large data sets of protein-protein interactions and integrating data analysis in automated workflows
- Familiarity with computational modeling of protein-protein interactions
This Role Might Be Perfect For You If…
You are curious and passionate about science and drug discovery and want to work with a fast-moving team that values scientific boldness and innovation. This role requires deep technical expertise combined with a willingness to work thoughtfully and quickly to solve scientific challenges in a collaborative manner. You value an experimental approach and generating high-quality data to empower rapid, data-driven decision-making, with a commitment to meet or beat critical deadlines. You should be a team player who is also proactive and resourceful.
If you’re excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply!
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
Seniority level
- Mid-Senior level
Employment type
- Full-time
Job function
- Research, Analyst, and Information Technology
Referrals increase your chances of interviewing at Manifold Bio by 2x
Get notified about new Senior Scientist jobs in Boston, MA.
Note: This description focuses on the role and required qualifications; unrelated job listings and site boilerplate have been removed.
#J-18808-Ljbffr