BioSpace
SVP, Head of Portfolio Strategy and Operations
BioSpace, Waltham, Massachusetts, United States, 02254
Overview
Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ and follow us on X, LinkedIn and Facebook. Role Overview
The Head of Portfolio Strategy and Operations (PS&O) drives successful delivery of key corporate objectives by ensuring the robust development of portfolio and program strategy and effective translation of strategy into integrated planning and timely operational execution across Dyne. The Head of PS&O reports into the Chief Executive Officer (CEO) and is a member of the Dyne Executive Committee (EC). The Head Of PS&O oversees Program Leadership, Program Management and Clinical Operations at Dyne by managing, coaching and guiding the Head of Clin Ops, Head of PM and the Program Team Leaders to enable exceptional performance of cross-functional program teams and clinical studies across the Dyne portfolio. Key Responsibilities
Lead and develop team of Program Team Leaders and Program Managers to effectively advance Dyne Programs and foster seamless integration and communication across the company. Drive understanding and inspire the big picture thinking of corporate, portfolio and program strategy and cross-functional interdependencies in order to lead execution across all Programs. Partner with Program Team Leaders to provide strategic and operational leadership to programs to achieve Program and company goals. Ensure effective partnership with cross-functional representatives to develop comprehensive product development, commercialization and lifecycle management plans that optimize value, time, resources, risk, and alignment with business objectives. Oversee and enable high-performing cross-functional Program Teams, focusing on both the "what" (strategy, priorities, output, resources) and the "how" (team environment). Establish a robust and well-understood Program strategy for bringing a life-changing medicine to patients in need. Manage the Program Team model at Dyne: develop and maintain clear Program plans with activities, deliverables, responsibilities, and timing; enable strategic decision-making, scenario planning and options analysis; ensure engagement and issue resolution within teams. Develop foundations for effective Portfolio Management (integrated portfolio views; key milestones and decisions; portfolio scenarios for optimization) and maintain Portfolio views aligned with Program plans and Dyne financials. Drive Portfolio Review preparation and decisions; partner on yearly financial planning and long-range planning. Lead and develop Clinical Operations to advance the portfolio of clinical studies: provide strategic operational guidance to ensure trials are defined, planned and executed to a high quality; develop vendor oversight processes; ensure compliance with SOPs and ICH-GCP guidelines. Establish, implement, and proactively manage clinical trial processes, outsourcing, and performance indicators; regularly report trial status and address challenges and gaps; Provide strategic input to risk analysis and mitigation for clinical trials; oversee budgets and forecasting for initiated studies; contribute to SOP development and cross-functional initiatives. Knowledge & Skills
Experience in Phase 1-3 drug development is required; product launch/early commercialization experience is a strong plus. Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent; 15+ years of pharmaceutical leadership in drug development or 12+ years in development/commercial leadership with cross-functional experience; strong knowledge of neuromuscular diseases; rare genetic diseases preferred. Proven track record in leading Clinical Operations, including hiring and managing staff, vendor/CRO management, and resource optimization across studies. Other Key Traits Include
Business-oriented leader who can shape and communicate the vision for the Dyne portfolio and drive product strategy execution. Strong people leadership with ability to coach high-caliber experts and build cohesive teams. Experience building high-performing teams and guiding data-driven decisions in complex environments. Sense of urgency with ability to pace work to meet milestones in a competitive setting. Excellent verbal and written communication skills with stakeholders and teams. Comfort with ambiguity and ability to provide steadiness amid shifting priorities. Other Information
Dyne Therapeutics is an equal opportunity employer and will not discriminate on age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any protected class. Seniority level: Executive Employment type: Full-time Job function: Business Development and Sales
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Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ and follow us on X, LinkedIn and Facebook. Role Overview
The Head of Portfolio Strategy and Operations (PS&O) drives successful delivery of key corporate objectives by ensuring the robust development of portfolio and program strategy and effective translation of strategy into integrated planning and timely operational execution across Dyne. The Head of PS&O reports into the Chief Executive Officer (CEO) and is a member of the Dyne Executive Committee (EC). The Head Of PS&O oversees Program Leadership, Program Management and Clinical Operations at Dyne by managing, coaching and guiding the Head of Clin Ops, Head of PM and the Program Team Leaders to enable exceptional performance of cross-functional program teams and clinical studies across the Dyne portfolio. Key Responsibilities
Lead and develop team of Program Team Leaders and Program Managers to effectively advance Dyne Programs and foster seamless integration and communication across the company. Drive understanding and inspire the big picture thinking of corporate, portfolio and program strategy and cross-functional interdependencies in order to lead execution across all Programs. Partner with Program Team Leaders to provide strategic and operational leadership to programs to achieve Program and company goals. Ensure effective partnership with cross-functional representatives to develop comprehensive product development, commercialization and lifecycle management plans that optimize value, time, resources, risk, and alignment with business objectives. Oversee and enable high-performing cross-functional Program Teams, focusing on both the "what" (strategy, priorities, output, resources) and the "how" (team environment). Establish a robust and well-understood Program strategy for bringing a life-changing medicine to patients in need. Manage the Program Team model at Dyne: develop and maintain clear Program plans with activities, deliverables, responsibilities, and timing; enable strategic decision-making, scenario planning and options analysis; ensure engagement and issue resolution within teams. Develop foundations for effective Portfolio Management (integrated portfolio views; key milestones and decisions; portfolio scenarios for optimization) and maintain Portfolio views aligned with Program plans and Dyne financials. Drive Portfolio Review preparation and decisions; partner on yearly financial planning and long-range planning. Lead and develop Clinical Operations to advance the portfolio of clinical studies: provide strategic operational guidance to ensure trials are defined, planned and executed to a high quality; develop vendor oversight processes; ensure compliance with SOPs and ICH-GCP guidelines. Establish, implement, and proactively manage clinical trial processes, outsourcing, and performance indicators; regularly report trial status and address challenges and gaps; Provide strategic input to risk analysis and mitigation for clinical trials; oversee budgets and forecasting for initiated studies; contribute to SOP development and cross-functional initiatives. Knowledge & Skills
Experience in Phase 1-3 drug development is required; product launch/early commercialization experience is a strong plus. Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent; 15+ years of pharmaceutical leadership in drug development or 12+ years in development/commercial leadership with cross-functional experience; strong knowledge of neuromuscular diseases; rare genetic diseases preferred. Proven track record in leading Clinical Operations, including hiring and managing staff, vendor/CRO management, and resource optimization across studies. Other Key Traits Include
Business-oriented leader who can shape and communicate the vision for the Dyne portfolio and drive product strategy execution. Strong people leadership with ability to coach high-caliber experts and build cohesive teams. Experience building high-performing teams and guiding data-driven decisions in complex environments. Sense of urgency with ability to pace work to meet milestones in a competitive setting. Excellent verbal and written communication skills with stakeholders and teams. Comfort with ambiguity and ability to provide steadiness amid shifting priorities. Other Information
Dyne Therapeutics is an equal opportunity employer and will not discriminate on age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any protected class. Seniority level: Executive Employment type: Full-time Job function: Business Development and Sales
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