Enlaza Therapeutics
Sr. Principal Scientist/Associate Director – Antibody Engineering
Enlaza Therapeutics, San Diego, California, United States, 92154
Senior Principal Scientist/Associate Director – Antibody Engineering
If your skills, experience, and qualifications match those in this job overview, do not delay your application. Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.
Role Description:
We seek a leader in the field with extensive experience in engineering and optimization of hit molecules to direct and oversee the protein engineering group. The successful candidate will have a deep understanding of structure-function relationships and integrate protein sciences with biological mechanisms to design and execute on discovery campaigns. They will demonstrate exquisite communication and collaboration and will work closely with empirical and computational protein engineering staff and will be a key scientific partner for multiple project and functional leads.
Responsibilities:
Use subject-matter expertise in protein engineering to advise teams on therapeutic formatting, target structure-function hypotheses, and design and selection of tool molecules and reagents
Directly supervise protein engineering scientists, providing technical oversight and professional development
Act as project team lead for discovery programs and ensure delivery of key project goals and milestones
Closely collaborate and coordinate with inter-disciplinary discovery and development function leads, scientists and project management to progress molecules from initial hits to developable clinical candidates
Oversee or perform design and construction of antibody/protein combinatorial libraries and engineering campaigns
Lead continuous improvement in laboratory workflows
Supervise the collection, aggregation and curation of experimental and theoretical data to inform predictive algorithms
Assist scientific leadership with technology development and strategy
Required Skills and Experience:
Advanced degree (MS, PhD) in Biochemistry, Chemistry, or other relevant discipline and 7+ years of directly related biopharmaceutical industry experience
Deep knowledge of protein structure, interactions, and physicochemical properties
Experience directly managing scientists
Competence in leading cross-functional project teams from target validation, through discovery and optimization, to development candidate
Advanced understanding of sequence and structure features and properties of multiple antibody formats (traditional mAbs, bi/multi-specifics, scFvs, single domain antibodies, and others)
Extensive hands-on experience with therapeutic protein and antibody engineering, humanization, liability removal, and optimization
Background in leveraging developability assessment (solubility, stability, impact of formulation, manufacturability) to optimize protein design
Familiarity with advanced in silico experiments, computer programming, databases, and machine learning integration in antibody discovery/engineering
Additional Experience Preferred but Not Required:
Experience with plate-based assay design and development and high-throughput workflows
Experience with engineering of small proteins or enzymes
Ability to synthesize structural and biophysical data, including epitope mapping, binding kinetics and physicochemical profiling, to inform decision-making
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Job Type:
Full-time
$170,000-190,000
Supplemental Pay Types:
Health insurance
Vision insurance
Flexible spending account
Employee assistance program
401(k)
Life insurance
Relocation assistance
Parental leave
Flexible vacation
Year-end winter break
Seniority level: Director
Employment type: Full-time
Job function: Research, Analyst, and Information Technology
Referrals increase your chances of interviewing at Enlaza Therapeutics by 2x
Get notified about new Senior Principal Scientist jobs in
San Diego, CA .
San Diego Metropolitan Area 2 days ago
Related roles include: Senior Principal Scientist, Research Associate, Quality Control, Scientist / Senior Scientist, and Quality Control positions. #J-18808-Ljbffr
If your skills, experience, and qualifications match those in this job overview, do not delay your application. Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.
Role Description:
We seek a leader in the field with extensive experience in engineering and optimization of hit molecules to direct and oversee the protein engineering group. The successful candidate will have a deep understanding of structure-function relationships and integrate protein sciences with biological mechanisms to design and execute on discovery campaigns. They will demonstrate exquisite communication and collaboration and will work closely with empirical and computational protein engineering staff and will be a key scientific partner for multiple project and functional leads.
Responsibilities:
Use subject-matter expertise in protein engineering to advise teams on therapeutic formatting, target structure-function hypotheses, and design and selection of tool molecules and reagents
Directly supervise protein engineering scientists, providing technical oversight and professional development
Act as project team lead for discovery programs and ensure delivery of key project goals and milestones
Closely collaborate and coordinate with inter-disciplinary discovery and development function leads, scientists and project management to progress molecules from initial hits to developable clinical candidates
Oversee or perform design and construction of antibody/protein combinatorial libraries and engineering campaigns
Lead continuous improvement in laboratory workflows
Supervise the collection, aggregation and curation of experimental and theoretical data to inform predictive algorithms
Assist scientific leadership with technology development and strategy
Required Skills and Experience:
Advanced degree (MS, PhD) in Biochemistry, Chemistry, or other relevant discipline and 7+ years of directly related biopharmaceutical industry experience
Deep knowledge of protein structure, interactions, and physicochemical properties
Experience directly managing scientists
Competence in leading cross-functional project teams from target validation, through discovery and optimization, to development candidate
Advanced understanding of sequence and structure features and properties of multiple antibody formats (traditional mAbs, bi/multi-specifics, scFvs, single domain antibodies, and others)
Extensive hands-on experience with therapeutic protein and antibody engineering, humanization, liability removal, and optimization
Background in leveraging developability assessment (solubility, stability, impact of formulation, manufacturability) to optimize protein design
Familiarity with advanced in silico experiments, computer programming, databases, and machine learning integration in antibody discovery/engineering
Additional Experience Preferred but Not Required:
Experience with plate-based assay design and development and high-throughput workflows
Experience with engineering of small proteins or enzymes
Ability to synthesize structural and biophysical data, including epitope mapping, binding kinetics and physicochemical profiling, to inform decision-making
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Job Type:
Full-time
$170,000-190,000
Supplemental Pay Types:
Health insurance
Vision insurance
Flexible spending account
Employee assistance program
401(k)
Life insurance
Relocation assistance
Parental leave
Flexible vacation
Year-end winter break
Seniority level: Director
Employment type: Full-time
Job function: Research, Analyst, and Information Technology
Referrals increase your chances of interviewing at Enlaza Therapeutics by 2x
Get notified about new Senior Principal Scientist jobs in
San Diego, CA .
San Diego Metropolitan Area 2 days ago
Related roles include: Senior Principal Scientist, Research Associate, Quality Control, Scientist / Senior Scientist, and Quality Control positions. #J-18808-Ljbffr