Eli Lilly and Company
Sr Advisor / Scientific Director - Chemistry – Fragment Hit Elaboration
Eli Lilly and Company, Indianapolis, Indiana, us, 46262
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and contribute to communities through philanthropy and volunteerism. We are looking for people who are determined to make life better for people around the world. Lilly Small Molecule Discovery
focuses on creating molecules that improve lives through cutting-edge science, with a commitment to breakthrough efficacy and safety margins. The culture emphasizes open collaboration, individual accountability, and fast, nimble execution. Discovery Technology and Platforms
is a function aimed at accelerating molecule discovery through optimized platforms, streamlined lab operations, and data connectivity, with exploration of novel technologies and capabilities. About the Novel Platforms Team The Novel Platforms team identifies and develops transformative technologies to improve hit finding, mechanism of action exploration, and molecular design, turning high-potential ideas into mature platforms embedded across Lilly’s discovery organization. About the Role
Lilly Small Molecule Discovery is seeking a
Chemist
to join our
Novel Platforms
Fragment-based Discovery
team. This is a hands-on, lab-based role with no direct reports. The role focuses on developing internal capabilities in fragment-based ligand design (FBLD). We are looking for a
Chemist
with strong expertise in developing fragment hits into pre-lead candidates. You will collaborate with a multidisciplinary team to develop workflows and methods to deliver a robust platform for FBLD enabling innovative therapeutic discovery. Key Responsibilities
Lead strategy and execution for early-stage medicinal chemistry from fragment hit identification to pre-lead candidate nomination. Triage and extract key pharmacophoric and structural insights from early biophysics and fragment screening data. Coordinate with internal and external chemistry resources to prioritize and ensure timely delivery of the chemical matter. Partner with chemistry, biophysics, structural biology and AI/ML teams to coordinate the progression of fragment hits to portfolio candidates across several protein targets. Required Qualifications
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry. Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting; BS with 10+ years, MS with 8+ years, or PhD with 5+ years of experience. Demonstrated success in FBLD taking low affinity fragment hits to pre-lead candidate molecules (nM range) and ideally beyond (IND, market). Proficiency with molecular modeling, MD, FEP, AI-assisted design, and cheminformatics. Proven ability to independently design experiments, troubleshoot challenges, and collaborate in a fast-paced environment. Additional Preferences
Proficiency with molecular modeling, MD, FEP, AI-assisted design, and cheminformatics. Proven ability to independently design experiments, troubleshoot challenges, and effectively collaborate in a fast-paced environment. Excellent communication, documentation, and scientific presentation skills. Passion for platform development, continuous optimization, and operational excellence with strong emphasis on data quality and reproducibility. Adaptability and resilience in a fast-paced, evolving research environment. Experience in lead compound optimization for potency, selectivity, ADME and PK. Additional Information
Physical Demands / Travel
The physical demands of this job are consistent with a laboratory environment. This position will require travel. The physical demands described are representative of those that must be met to perform the essential functions of this job. Work Environment
This position’s work environment is a laboratory. The work environment characteristics described are representative of those encountered while performing the essential functions of this job. *To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Lilly is committed to helping individuals with disabilities participate in the workforce and ensuring equal opportunities in applications. If you require accommodation to submit a resume, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation. This is for accommodation requests related to the application process. Lilly is proud to be an EEO Employer and does not discriminate on age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for members and are open to all employees. Current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, JILN, Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE, Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble. Learn more about all groups. Actual compensation will depend on education, experience, skills, and location. The anticipated wage for this position is $148,500 - $232,100. Full-time employees are eligible for a company bonus (depending on company and individual performance). Lilly offers a comprehensive benefits program including 401(k); pension; medical, dental, vision and prescription benefits; flexible benefits; life insurance; leave benefits; and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion. #WeAreLilly
#J-18808-Ljbffr
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and contribute to communities through philanthropy and volunteerism. We are looking for people who are determined to make life better for people around the world. Lilly Small Molecule Discovery
focuses on creating molecules that improve lives through cutting-edge science, with a commitment to breakthrough efficacy and safety margins. The culture emphasizes open collaboration, individual accountability, and fast, nimble execution. Discovery Technology and Platforms
is a function aimed at accelerating molecule discovery through optimized platforms, streamlined lab operations, and data connectivity, with exploration of novel technologies and capabilities. About the Novel Platforms Team The Novel Platforms team identifies and develops transformative technologies to improve hit finding, mechanism of action exploration, and molecular design, turning high-potential ideas into mature platforms embedded across Lilly’s discovery organization. About the Role
Lilly Small Molecule Discovery is seeking a
Chemist
to join our
Novel Platforms
Fragment-based Discovery
team. This is a hands-on, lab-based role with no direct reports. The role focuses on developing internal capabilities in fragment-based ligand design (FBLD). We are looking for a
Chemist
with strong expertise in developing fragment hits into pre-lead candidates. You will collaborate with a multidisciplinary team to develop workflows and methods to deliver a robust platform for FBLD enabling innovative therapeutic discovery. Key Responsibilities
Lead strategy and execution for early-stage medicinal chemistry from fragment hit identification to pre-lead candidate nomination. Triage and extract key pharmacophoric and structural insights from early biophysics and fragment screening data. Coordinate with internal and external chemistry resources to prioritize and ensure timely delivery of the chemical matter. Partner with chemistry, biophysics, structural biology and AI/ML teams to coordinate the progression of fragment hits to portfolio candidates across several protein targets. Required Qualifications
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry. Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting; BS with 10+ years, MS with 8+ years, or PhD with 5+ years of experience. Demonstrated success in FBLD taking low affinity fragment hits to pre-lead candidate molecules (nM range) and ideally beyond (IND, market). Proficiency with molecular modeling, MD, FEP, AI-assisted design, and cheminformatics. Proven ability to independently design experiments, troubleshoot challenges, and collaborate in a fast-paced environment. Additional Preferences
Proficiency with molecular modeling, MD, FEP, AI-assisted design, and cheminformatics. Proven ability to independently design experiments, troubleshoot challenges, and effectively collaborate in a fast-paced environment. Excellent communication, documentation, and scientific presentation skills. Passion for platform development, continuous optimization, and operational excellence with strong emphasis on data quality and reproducibility. Adaptability and resilience in a fast-paced, evolving research environment. Experience in lead compound optimization for potency, selectivity, ADME and PK. Additional Information
Physical Demands / Travel
The physical demands of this job are consistent with a laboratory environment. This position will require travel. The physical demands described are representative of those that must be met to perform the essential functions of this job. Work Environment
This position’s work environment is a laboratory. The work environment characteristics described are representative of those encountered while performing the essential functions of this job. *To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Lilly is committed to helping individuals with disabilities participate in the workforce and ensuring equal opportunities in applications. If you require accommodation to submit a resume, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation. This is for accommodation requests related to the application process. Lilly is proud to be an EEO Employer and does not discriminate on age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for members and are open to all employees. Current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, JILN, Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE, Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble. Learn more about all groups. Actual compensation will depend on education, experience, skills, and location. The anticipated wage for this position is $148,500 - $232,100. Full-time employees are eligible for a company bonus (depending on company and individual performance). Lilly offers a comprehensive benefits program including 401(k); pension; medical, dental, vision and prescription benefits; flexible benefits; life insurance; leave benefits; and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion. #WeAreLilly
#J-18808-Ljbffr