Chan Zuckerberg Biohub Network
Computational Biologist, CRISPR Informatics (Biohub SF)
Chan Zuckerberg Biohub Network, San Francisco, California, United States, 94199
Overview
Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together Stanford, UC Berkeley, and UC San Francisco into a collaborative technology and discovery engine. CZ Biohub SF supports engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new diagnostics and effective therapies. We value scholarly excellence; disruptive innovation; hands-on engineering, hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all. Our Vision: We chart the dynamic architecture of cells at a scale and resolution once thought impossible. By uniting biology, engineering, and computation, we invent the breakthrough technologies this vision demands. Recent innovations from our team include an automated CRISPR experiment design engine that performs comprehensive optimizations while operating at the genome-wide scale (Peng et al., Nucleic Acids Research 2024). Leveraging such tools, we generated open-source datasets that illuminate the spatial organization of the human proteome in healthy and diseased states (Cho et al., Science 2022; Hein et al., Cell 2025). The Opportunity
Were gearing up for our most ambitious push yet. As our next
Computational Biologist , you will architect and build the computational backbone that powers our upcoming large-scale CRISPR experiments in human cells, organoids, and even whole organisms (zebrafish). These studies will span precise knock-in/out, high-content image-based CRISPR screening, and programmable expression controlconverting diverse perturbation datasets into systematic biological insights. Join us in San Francisco (with a planned move to Redwood City in two years). This role will be based in San Francisco initially, with a planned transition to Redwood City in two years. You will Architect, build and maintain computation workflows for CRISPR design and edit-outcome analysis. Analyze genome-scale CRISPR perturbation datasets and identify emergent gene-function and pathway networks. Work with molecular biologists, imaging scientists, and software engineers to plan large-scale CRISPR experiments and interpret results. Package, document and rigorously test code, computational pipelines and datasets for open-source release. Author publications and present research findings at conferences.
You have
Essential Ph.D. in Computational Biology, Bioinformatics, Bioengineering, Genomics or a related discipline. Candidates with a masters degree and 3 years of relevant experience will be considered. 2+ years of deep, current knowledge of CRISPR genome-engineering technologies (e.g. CRISPRi/a, base/prime editing, CRISPR-based imaging) and the underlying molecular biology. Proven track record of developing computational pipelines for CRISPR design and edit-outcome analysis. Fluency in Python (or similar), experience with workflow management frameworks (e.g., Nextflow, Snakemake), and strong software engineering practices including testing, continuous integration, documentation, and version control. A collaborative, team-focused mindset coupled with outstanding communication skills.
Nice to have
Experience in analyzing CRISPR perturbations datasets at single cell resolution (e.g. perturb-seq). Experience in designing, optimizing and executing bioinformatics pipelines for amplicon sequencing, whole-genome sequencing and genome variant analyses. Experience in utilizing high-performance computing systems for large-scale data processing and analysis. Prior contributions to open-source projects or data resources.
Compensation
The San Francisco base pay range for this role is Computational Biologist I = $108,000 - $149,000 and Computational Biologist II = $132,000 - $182,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. What We Provide
Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease A collegial and collaborative environment consisting of diverse expertise Access to collaborators, resources and facilities at our three partner universities (Stanford University, UC Berkeley, and UC San Francisco) and at partner organizations in the SF Bay Area and beyond Competitive compensation and benefits commensurate with the experience
If youre interested in a role but your previous experience doesnt perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Benefits
We offer a robust benefits program including healthcare, life and disability insurance, commuter subsidies, fertility services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists. The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law. Pursuant to the California Fair Chance Act, we will consider for employment qualified applicants with arrest and conviction records. Head hunters and recruitment agencies may not submit resumes through this website or directly to managers. The CZ Biohub Network does not accept unsolicited headhunter resumes and will not pay fees to any third-party agency or company that does not have a signed agreement with the CZ Biohub Network. Details Seniority level: Mid-Senior level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Research Services
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Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together Stanford, UC Berkeley, and UC San Francisco into a collaborative technology and discovery engine. CZ Biohub SF supports engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new diagnostics and effective therapies. We value scholarly excellence; disruptive innovation; hands-on engineering, hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all. Our Vision: We chart the dynamic architecture of cells at a scale and resolution once thought impossible. By uniting biology, engineering, and computation, we invent the breakthrough technologies this vision demands. Recent innovations from our team include an automated CRISPR experiment design engine that performs comprehensive optimizations while operating at the genome-wide scale (Peng et al., Nucleic Acids Research 2024). Leveraging such tools, we generated open-source datasets that illuminate the spatial organization of the human proteome in healthy and diseased states (Cho et al., Science 2022; Hein et al., Cell 2025). The Opportunity
Were gearing up for our most ambitious push yet. As our next
Computational Biologist , you will architect and build the computational backbone that powers our upcoming large-scale CRISPR experiments in human cells, organoids, and even whole organisms (zebrafish). These studies will span precise knock-in/out, high-content image-based CRISPR screening, and programmable expression controlconverting diverse perturbation datasets into systematic biological insights. Join us in San Francisco (with a planned move to Redwood City in two years). This role will be based in San Francisco initially, with a planned transition to Redwood City in two years. You will Architect, build and maintain computation workflows for CRISPR design and edit-outcome analysis. Analyze genome-scale CRISPR perturbation datasets and identify emergent gene-function and pathway networks. Work with molecular biologists, imaging scientists, and software engineers to plan large-scale CRISPR experiments and interpret results. Package, document and rigorously test code, computational pipelines and datasets for open-source release. Author publications and present research findings at conferences.
You have
Essential Ph.D. in Computational Biology, Bioinformatics, Bioengineering, Genomics or a related discipline. Candidates with a masters degree and 3 years of relevant experience will be considered. 2+ years of deep, current knowledge of CRISPR genome-engineering technologies (e.g. CRISPRi/a, base/prime editing, CRISPR-based imaging) and the underlying molecular biology. Proven track record of developing computational pipelines for CRISPR design and edit-outcome analysis. Fluency in Python (or similar), experience with workflow management frameworks (e.g., Nextflow, Snakemake), and strong software engineering practices including testing, continuous integration, documentation, and version control. A collaborative, team-focused mindset coupled with outstanding communication skills.
Nice to have
Experience in analyzing CRISPR perturbations datasets at single cell resolution (e.g. perturb-seq). Experience in designing, optimizing and executing bioinformatics pipelines for amplicon sequencing, whole-genome sequencing and genome variant analyses. Experience in utilizing high-performance computing systems for large-scale data processing and analysis. Prior contributions to open-source projects or data resources.
Compensation
The San Francisco base pay range for this role is Computational Biologist I = $108,000 - $149,000 and Computational Biologist II = $132,000 - $182,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. What We Provide
Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease A collegial and collaborative environment consisting of diverse expertise Access to collaborators, resources and facilities at our three partner universities (Stanford University, UC Berkeley, and UC San Francisco) and at partner organizations in the SF Bay Area and beyond Competitive compensation and benefits commensurate with the experience
If youre interested in a role but your previous experience doesnt perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Benefits
We offer a robust benefits program including healthcare, life and disability insurance, commuter subsidies, fertility services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists. The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law. Pursuant to the California Fair Chance Act, we will consider for employment qualified applicants with arrest and conviction records. Head hunters and recruitment agencies may not submit resumes through this website or directly to managers. The CZ Biohub Network does not accept unsolicited headhunter resumes and will not pay fees to any third-party agency or company that does not have a signed agreement with the CZ Biohub Network. Details Seniority level: Mid-Senior level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Research Services
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