Revolution Medicines
Senior Director, Portfolio Management
Revolution Medicines, San Francisco, California, United States, 94199
Overview
Senior Director, Portfolio Management at Revolution Medicines. Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline includes RAS(ON) Inhibitors and RAS Companion Inhibitors for combination strategies. As a member of the Revolution Medicines team, you will work with colleagues to advance therapies for cancers with RAS pathway mutations. The Opportunity
Revolution Medicines is seeking a motivated individual with a scientific background to lead Portfolio Management within the Pharmaceutical Development and Manufacturing (PDM) organization. This leader will head a cross-functional team to develop an enterprise-focused PDM strategy and provide clarity for functional leaders and decision-makers, enabling strategic alignment and prioritization. The role includes leading enterprise- and PDM-focused strategic analyses and key initiatives. Responsibilities
Facilitate cross-functional meetings with the Corporate PM team and other PDM functional leads to develop, adapt, and drive the product strategy. Maintain a strategic, accurate view of Revolution Medicines’ product portfolio, including initiative status, impact, and maturity. Prepare and improve regular and ad hoc portfolio reports and dashboards for key stakeholders. Lead long-range planning for all clinical and commercial projects (3–5 year horizon) based on clinical/commercial demand, supply chain risks, CDMOs capacity, lifecycle management changes, and market approvals. Analyze portfolio trends, risks, and opportunities to support decision-making and continuous improvement. Manage an integrated product plan with near- and long-term cross-functional impacts, aligned with DS, ADQC, DP, SC, CMC PM, CMC regulatory and QA, to meet PDM goals. Forecast program-level resource demand with functional areas. Collaborate with CMC PM to develop integrated program timelines, budgets, and scenarios for Discovery, emerging, and clinical programs, focusing on immediate and short-term ( Integrate cross-functional timelines into a single global program timeline accessible to finance and management for decision-making. Enhance portfolio alignment, visibility, and strategic communication with product leads and stakeholders. Interface with the financial planning team to capture budget changes in forecast models. Manage inputs for annual budgets, reforecasts, and long-range plans. Define and maintain KPIs to track progress, impact, and resource utilization across PDM. Identify, plan, and implement process improvement projects to streamline operations, improve quality, reduce costs and cycle times, and enhance customer satisfaction. Consult with PDM functional leaders to diagnose and solve organizational development and effectiveness issues. Participate in supply chain risk assessments and monitor inventory risks, developing mitigation strategies such as buffer stock or alternate sourcing. Required Skills, Experience and Education
Sc. or M.Sc. in a scientific field with 15+ years of experience in pharmaceutical strategic sourcing and/or supply chain. Experience managing both strategic and tactical/operational projects. Working knowledge of clinical manufacturing, regulatory, QA, and cGMP requirements for small molecules. Working knowledge of small molecule drug development and commercialization, including oral solid dosage form development, manufacturing, scale-up, and validation. Working knowledge of pharma end-to-end supply chain, with oral solid dosage form-related supply a plus. Proven ability to lead collaborative and creative strategic problem solving by breaking down issues, identifying options, synthesizing insights, and driving to action. Strong project management, facilitation, and problem-solving skills. Strong organizational and time management skills. Effective, open, and transparent communication skills (verbal and written). Ability to work on multiple projects and meet deadlines. Self-starter with comfort in ambiguity and complexity, capable of multitasking while delivering quality results. Team-oriented, progressive thinker who thrives in an innovative environment. Preferred Skills
Working knowledge of commercial manufacturing. Experience developing, negotiating, and executing clinical or commercial supply and/or quality agreements. Compensation and Location
The base pay salary range for this full-time onsite role at our headquarters in Redwood City, CA is $236,000 – $295,000 USD. Base pay ranges are determined by role, level, and location and may be adjusted for the local market. Please note that base pay is one part of the total rewards package, which includes competitive cash compensation, equity awards, strong benefits, and development opportunities. Equal Opportunity and Privacy
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. We protect personal data seriously and respect your privacy. We collect and use data in accordance with our CCPA Notice and Privacy Policy. For more information, contact privacy@revmed.com. Location information: Redwood City, CA (Onsite). Job Details
Seniority level: Director Employment type: Full-time Job function: Science, Manufacturing, and Strategy/Planning Industries: Biotechnology Research and Pharmaceutical Manufacturing
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Senior Director, Portfolio Management at Revolution Medicines. Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline includes RAS(ON) Inhibitors and RAS Companion Inhibitors for combination strategies. As a member of the Revolution Medicines team, you will work with colleagues to advance therapies for cancers with RAS pathway mutations. The Opportunity
Revolution Medicines is seeking a motivated individual with a scientific background to lead Portfolio Management within the Pharmaceutical Development and Manufacturing (PDM) organization. This leader will head a cross-functional team to develop an enterprise-focused PDM strategy and provide clarity for functional leaders and decision-makers, enabling strategic alignment and prioritization. The role includes leading enterprise- and PDM-focused strategic analyses and key initiatives. Responsibilities
Facilitate cross-functional meetings with the Corporate PM team and other PDM functional leads to develop, adapt, and drive the product strategy. Maintain a strategic, accurate view of Revolution Medicines’ product portfolio, including initiative status, impact, and maturity. Prepare and improve regular and ad hoc portfolio reports and dashboards for key stakeholders. Lead long-range planning for all clinical and commercial projects (3–5 year horizon) based on clinical/commercial demand, supply chain risks, CDMOs capacity, lifecycle management changes, and market approvals. Analyze portfolio trends, risks, and opportunities to support decision-making and continuous improvement. Manage an integrated product plan with near- and long-term cross-functional impacts, aligned with DS, ADQC, DP, SC, CMC PM, CMC regulatory and QA, to meet PDM goals. Forecast program-level resource demand with functional areas. Collaborate with CMC PM to develop integrated program timelines, budgets, and scenarios for Discovery, emerging, and clinical programs, focusing on immediate and short-term ( Integrate cross-functional timelines into a single global program timeline accessible to finance and management for decision-making. Enhance portfolio alignment, visibility, and strategic communication with product leads and stakeholders. Interface with the financial planning team to capture budget changes in forecast models. Manage inputs for annual budgets, reforecasts, and long-range plans. Define and maintain KPIs to track progress, impact, and resource utilization across PDM. Identify, plan, and implement process improvement projects to streamline operations, improve quality, reduce costs and cycle times, and enhance customer satisfaction. Consult with PDM functional leaders to diagnose and solve organizational development and effectiveness issues. Participate in supply chain risk assessments and monitor inventory risks, developing mitigation strategies such as buffer stock or alternate sourcing. Required Skills, Experience and Education
Sc. or M.Sc. in a scientific field with 15+ years of experience in pharmaceutical strategic sourcing and/or supply chain. Experience managing both strategic and tactical/operational projects. Working knowledge of clinical manufacturing, regulatory, QA, and cGMP requirements for small molecules. Working knowledge of small molecule drug development and commercialization, including oral solid dosage form development, manufacturing, scale-up, and validation. Working knowledge of pharma end-to-end supply chain, with oral solid dosage form-related supply a plus. Proven ability to lead collaborative and creative strategic problem solving by breaking down issues, identifying options, synthesizing insights, and driving to action. Strong project management, facilitation, and problem-solving skills. Strong organizational and time management skills. Effective, open, and transparent communication skills (verbal and written). Ability to work on multiple projects and meet deadlines. Self-starter with comfort in ambiguity and complexity, capable of multitasking while delivering quality results. Team-oriented, progressive thinker who thrives in an innovative environment. Preferred Skills
Working knowledge of commercial manufacturing. Experience developing, negotiating, and executing clinical or commercial supply and/or quality agreements. Compensation and Location
The base pay salary range for this full-time onsite role at our headquarters in Redwood City, CA is $236,000 – $295,000 USD. Base pay ranges are determined by role, level, and location and may be adjusted for the local market. Please note that base pay is one part of the total rewards package, which includes competitive cash compensation, equity awards, strong benefits, and development opportunities. Equal Opportunity and Privacy
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. We protect personal data seriously and respect your privacy. We collect and use data in accordance with our CCPA Notice and Privacy Policy. For more information, contact privacy@revmed.com. Location information: Redwood City, CA (Onsite). Job Details
Seniority level: Director Employment type: Full-time Job function: Science, Manufacturing, and Strategy/Planning Industries: Biotechnology Research and Pharmaceutical Manufacturing
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