Monte Rosa Therapeutics
Associate Director, Medicinal Chemistry – Lead Generation and Platform Chemistry
Monte Rosa Therapeutics, Boston, Massachusetts, us, 02298
Overview
Associate Director, Medicinal Chemistry – Lead Generation and Platform Chemistry, based in Boston. This role is pivotal in the global discovery engine, bridging early-stage compound discovery with delivery of optimized clinical drug candidates. Initially a hands-on contributor, the position is expected to evolve into a leadership role overseeing a team of scientists. We seek candidates with deep experience in targeted protein degradation and a track record of pioneering novel chemical modalities and delivering high-quality drug candidates. The ideal candidate will thrive in a fast-paced, collaborative environment and be driven by advancing targeted protein degradation to new frontiers. Responsibilities
Lead the design and execution of medicinal chemistry strategies to support early- and late-stage lead discovery and optimization programs. Execute synthesis through our CRO network. Collaborate cross-functionally with biology, biophysics, DMPK, structural biology, and computational chemistry teams to integrate scientific insights into compound design. Drive exploration and development of molecular glues and other novel modalities for targeted protein degradation. Establish and lead chemistry efforts from hit identification through lead optimization to clinical candidate nomination. Develop and apply structure-activity relationships (SAR) to improve potency, selectivity, and pharmacokinetic properties. Provide strategic input into platform technology development and innovations that enhance discovery of next-generation therapeutics. Mentor and lead a high-performing team of medicinal chemists over time. Contribute to a culture of scientific excellence, rigor, and innovation through active participation in project teams, internal discussions, and external collaborations. Communicate research findings clearly in internal meetings, project reviews, and external presentations or publications and patents. Qualifications
Ph.D. in Organic or Medicinal Chemistry with significant postdoctoral or industry experience of at least 10 years. Proven track record of impact in small molecule drug discovery, preferably with expertise in targeted protein degradation. Extensive experience with effective use of external resources (CROs, single contractual contributors and consultants). Strong knowledge of SAR, ADME, PK/PD, and drug-like property optimization. Demonstrated success in leading or significantly contributing to projects that resulted in clinical candidate nomination. Experience working in cross-disciplinary discovery teams; ability to integrate complex data into actionable plans. Strong leadership, mentoring, and communication skills, with the ability to inspire and guide others.
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Associate Director, Medicinal Chemistry – Lead Generation and Platform Chemistry, based in Boston. This role is pivotal in the global discovery engine, bridging early-stage compound discovery with delivery of optimized clinical drug candidates. Initially a hands-on contributor, the position is expected to evolve into a leadership role overseeing a team of scientists. We seek candidates with deep experience in targeted protein degradation and a track record of pioneering novel chemical modalities and delivering high-quality drug candidates. The ideal candidate will thrive in a fast-paced, collaborative environment and be driven by advancing targeted protein degradation to new frontiers. Responsibilities
Lead the design and execution of medicinal chemistry strategies to support early- and late-stage lead discovery and optimization programs. Execute synthesis through our CRO network. Collaborate cross-functionally with biology, biophysics, DMPK, structural biology, and computational chemistry teams to integrate scientific insights into compound design. Drive exploration and development of molecular glues and other novel modalities for targeted protein degradation. Establish and lead chemistry efforts from hit identification through lead optimization to clinical candidate nomination. Develop and apply structure-activity relationships (SAR) to improve potency, selectivity, and pharmacokinetic properties. Provide strategic input into platform technology development and innovations that enhance discovery of next-generation therapeutics. Mentor and lead a high-performing team of medicinal chemists over time. Contribute to a culture of scientific excellence, rigor, and innovation through active participation in project teams, internal discussions, and external collaborations. Communicate research findings clearly in internal meetings, project reviews, and external presentations or publications and patents. Qualifications
Ph.D. in Organic or Medicinal Chemistry with significant postdoctoral or industry experience of at least 10 years. Proven track record of impact in small molecule drug discovery, preferably with expertise in targeted protein degradation. Extensive experience with effective use of external resources (CROs, single contractual contributors and consultants). Strong knowledge of SAR, ADME, PK/PD, and drug-like property optimization. Demonstrated success in leading or significantly contributing to projects that resulted in clinical candidate nomination. Experience working in cross-disciplinary discovery teams; ability to integrate complex data into actionable plans. Strong leadership, mentoring, and communication skills, with the ability to inspire and guide others.
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